Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
Identifieur interne : 000F81 ( PubMed/Corpus ); précédent : 000F80; suivant : 000F82Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
Auteurs : Xavier Drouot ; Satoru Oshino ; Bechir Jarraya ; Laurent Besret ; Haruhiko Kishima ; Philippe Remy ; Julien Dauguet ; Jean Pascal Lefaucheur ; Frédéric Dollé ; Françoise Condé ; Michel Bottlaender ; Marc Peschanski ; Yves Kéravel ; Philippe Hantraye ; Stéphane PalfiSource :
- Neuron [ 0896-6273 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Chronic Disease, Disease Models, Animal, Electric Stimulation, Electrophysiology, Fluorodeoxyglucose F18, MPTP Poisoning (complications), MPTP Poisoning (diagnostic imaging), MPTP Poisoning (physiopathology), Motor Cortex (diagnostic imaging), Motor Cortex (physiopathology), Movement Disorders (etiology), Movement Disorders (physiopathology), Papio, Parkinson Disease (physiopathology), Positron-Emission Tomography, Radiopharmaceuticals, Recovery of Function.
- MESH :
- chemical : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- complications : MPTP Poisoning.
- diagnostic imaging : MPTP Poisoning, Motor Cortex.
- etiology : Movement Disorders.
- physiopathology : MPTP Poisoning, Motor Cortex, Movement Disorders, Parkinson Disease.
- Animals, Chronic Disease, Disease Models, Animal, Electric Stimulation, Electrophysiology, Papio, Positron-Emission Tomography, Recovery of Function.
Abstract
A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.
DOI: 10.1016/j.neuron.2004.11.023
PubMed: 15572109
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pubmed:15572109Le document en format XML
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primate model of Parkinson's disease following motor cortex stimulation.</title><author><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name><affiliation><nlm:affiliation>URA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France.</nlm:affiliation></affiliation></author><author><name sortKey="Oshino, Satoru" sort="Oshino, Satoru" uniqKey="Oshino S" first="Satoru" last="Oshino">Satoru Oshino</name></author><author><name sortKey="Jarraya, Bechir" sort="Jarraya, Bechir" uniqKey="Jarraya B" first="Bechir" last="Jarraya">Bechir Jarraya</name></author><author><name sortKey="Besret, Laurent" sort="Besret, Laurent" uniqKey="Besret L" first="Laurent" last="Besret">Laurent Besret</name></author><author><name sortKey="Kishima, Haruhiko" sort="Kishima, Haruhiko" uniqKey="Kishima H" first="Haruhiko" last="Kishima">Haruhiko Kishima</name></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author><author><name sortKey="Dauguet, Julien" sort="Dauguet, Julien" uniqKey="Dauguet J" first="Julien" last="Dauguet">Julien Dauguet</name></author><author><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean Pascal" last="Lefaucheur">Jean Pascal Lefaucheur</name></author><author><name sortKey="Dolle, Frederic" sort="Dolle, Frederic" uniqKey="Dolle F" first="Frédéric" last="Dollé">Frédéric Dollé</name></author><author><name sortKey="Conde, Francoise" sort="Conde, Francoise" uniqKey="Conde F" first="Françoise" last="Condé">Françoise Condé</name></author><author><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name></author><author><name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name></author><author><name sortKey="Keravel, Yves" sort="Keravel, Yves" uniqKey="Keravel Y" first="Yves" last="Kéravel">Yves Kéravel</name></author><author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name></author><author><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name></author></analytic><series><title level="j">Neuron</title><idno type="ISSN">0896-6273</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chronic Disease</term><term>Disease Models, Animal</term><term>Electric Stimulation</term><term>Electrophysiology</term><term>Fluorodeoxyglucose F18</term><term>MPTP Poisoning (complications)</term><term>MPTP Poisoning (diagnostic imaging)</term><term>MPTP Poisoning (physiopathology)</term><term>Motor Cortex (diagnostic imaging)</term><term>Motor Cortex (physiopathology)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (physiopathology)</term><term>Papio</term><term>Parkinson Disease (physiopathology)</term><term>Positron-Emission Tomography</term><term>Radiopharmaceuticals</term><term>Recovery of Function</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>MPTP Poisoning</term><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>MPTP Poisoning</term><term>Motor Cortex</term><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chronic Disease</term><term>Disease Models, Animal</term><term>Electric Stimulation</term><term>Electrophysiology</term><term>Papio</term><term>Positron-Emission Tomography</term><term>Recovery of Function</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15572109</PMID><DateCreated><Year>2004</Year><Month>12</Month><Day>01</Day></DateCreated><DateCompleted><Year>2005</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0896-6273</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>5</Issue><PubDate><Year>2004</Year><Month>Dec</Month><Day>02</Day></PubDate></JournalIssue><Title>Neuron</Title><ISOAbbreviation>Neuron</ISOAbbreviation></Journal><ArticleTitle>Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.</ArticleTitle><Pagination><MedlinePgn>769-78</MedlinePgn></Pagination><Abstract><AbstractText>A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drouot</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>URA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oshino</LastName><ForeName>Satoru</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Jarraya</LastName><ForeName>Bechir</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Besret</LastName><ForeName>Laurent</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Kishima</LastName><ForeName>Haruhiko</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dauguet</LastName><ForeName>Julien</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Lefaucheur</LastName><ForeName>Jean Pascal</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Dollé</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Condé</LastName><ForeName>Françoise</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bottlaender</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Peschanski</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kéravel</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hantraye</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Palfi</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neuron</MedlineTA><NlmUniqueID>8809320</NlmUniqueID><ISSNLinking>0896-6273</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004558" MajorTopicYN="N">Electric Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020267" MajorTopicYN="N">MPTP Poisoning</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009069" MajorTopicYN="N">Movement Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010215" MajorTopicYN="N">Papio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019275" MajorTopicYN="N">Radiopharmaceuticals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020127" MajorTopicYN="N">Recovery of Function</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2003</Year><Month>10</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2004</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2004</Year><Month>11</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>12</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>1</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>12</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15572109</ArticleId><ArticleId IdType="pii">S0896627304007573</ArticleId><ArticleId 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