A case of severe dysexecutive syndrome consecutive to chronic bilateral pallidal stimulation.
Identifieur interne : 000122 ( Ncbi/Checkpoint ); précédent : 000121; suivant : 000123A case of severe dysexecutive syndrome consecutive to chronic bilateral pallidal stimulation.
Auteurs : K. Dujardin [France] ; P. Krystkowiak ; L. Defebvre ; S. Blond ; A. DestéeSource :
- Neuropsychologia [ 0028-3932 ] ; 2000.
English descriptors
- KwdEn :
- Attention, Cognition, Electric Stimulation Therapy (adverse effects), Electrodes, Implanted, Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Memory, Middle Aged, Nerve Net, Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (surgery), Psychomotor Performance.
- MESH :
- adverse effects : Electric Stimulation Therapy.
- physiopathology : Globus Pallidus, Parkinson Disease.
- psychology : Parkinson Disease.
- surgery : Globus Pallidus, Parkinson Disease.
- Attention, Cognition, Electrodes, Implanted, Female, Humans, Memory, Middle Aged, Nerve Net, Neuropsychological Tests, Psychomotor Performance.
Abstract
In treatment for severe Parkinson's disease (PD), a recent procedure was developed which consists of implanting electrodes in the internal Globus Pallidus (GPi) for chronic electrical stimulation. The consequences on cognitive function of such an intervention are quite variable. Although most group studies observed no significant post-operative change, individual cases of post-operative cognitive impairment were reported. The present study reports the case of a PD patient who underwent bilateral implantation of deep brain stimulation electrodes in the GPi and who, after surgery, suffered from a severe dysexecutive syndrome. An extensive neuropsychological examination showed a selective negative effect of pallidal stimulation on tests assessing executive function. When the stimulation was turned off, the impairment was partly reversible. This observation emphasizes the role of the GPi in executive function.
PubMed: 10865106
Affiliations:
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Dujardin</name><affiliation wicri:level="1"><nlm:affiliation>Neurologie A, CHRU de Lille, Hôpital Salengro, 59037 Lille, Cedex, France. kdujardin@nordnet.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurologie A, CHRU de Lille, Hôpital Salengro, 59037 Lille, Cedex</wicri:regionArea><wicri:noRegion>Cedex</wicri:noRegion><wicri:noRegion>Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Krystkowiak, P" sort="Krystkowiak, P" uniqKey="Krystkowiak P" first="P" last="Krystkowiak">P. Krystkowiak</name></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name></author><author><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S" last="Blond">S. Blond</name></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention</term><term>Cognition</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Electrodes, Implanted</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Memory</term><term>Middle Aged</term><term>Nerve Net</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (surgery)</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Attention</term><term>Cognition</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Memory</term><term>Middle Aged</term><term>Nerve Net</term><term>Neuropsychological Tests</term><term>Psychomotor Performance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In treatment for severe Parkinson's disease (PD), a recent procedure was developed which consists of implanting electrodes in the internal Globus Pallidus (GPi) for chronic electrical stimulation. The consequences on cognitive function of such an intervention are quite variable. Although most group studies observed no significant post-operative change, individual cases of post-operative cognitive impairment were reported. The present study reports the case of a PD patient who underwent bilateral implantation of deep brain stimulation electrodes in the GPi and who, after surgery, suffered from a severe dysexecutive syndrome. An extensive neuropsychological examination showed a selective negative effect of pallidal stimulation on tests assessing executive function. When the stimulation was turned off, the impairment was partly reversible. This observation emphasizes the role of the GPi in executive function.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S" last="Blond">S. Blond</name><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name><name sortKey="Krystkowiak, P" sort="Krystkowiak, P" uniqKey="Krystkowiak P" first="P" last="Krystkowiak">P. Krystkowiak</name></noCountry><country name="France"><noRegion><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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