Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
Identifieur interne : 000121 ( Ncbi/Checkpoint ); précédent : 000120; suivant : 000122Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
Auteurs : P. Krack [France] ; P L Dowsey ; A L Benabid ; N. Acarin ; A. Benazzouz ; G. Künig ; K L Leenders ; J A Obeso ; P. PollakSource :
- Neurology [ 0028-3878 ] ; 2000.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Drug Resistance, Electric Stimulation, Globus Pallidus (pathology), Humans, Levodopa (therapeutic use), Male, Middle Aged, Myocardial Ischemia (complications), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (surgery), Subthalamic Nucleus (pathology), Subthalamic Nucleus (surgery).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Myocardial Ischemia.
- drug therapy : Parkinson Disease, Secondary.
- etiology : Parkinson Disease, Secondary.
- pathology : Globus Pallidus, Subthalamic Nucleus.
- surgery : Parkinson Disease, Secondary, Subthalamic Nucleus.
- Drug Resistance, Electric Stimulation, Humans, Male, Middle Aged.
Abstract
The authors report a patient with postischemic parkinsonism who responded neither to levodopa nor to bilateral subthalamic nucleus (STN) stimulation. MRI revealed bilateral lesions of the substantia nigra, the striatum, the external pallidum, and part of the internal pallidum. PET showed reduced striatal dopa-decarboxylase activity, D2 receptor binding, and glucose metabolism. Perioperative microrecording showed low-frequency activity of STN cells. This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery.
PubMed: 10851392
Affiliations:
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pubmed:10851392Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.</title>
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<front><div type="abstract" xml:lang="en">The authors report a patient with postischemic parkinsonism who responded neither to levodopa nor to bilateral subthalamic nucleus (STN) stimulation. MRI revealed bilateral lesions of the substantia nigra, the striatum, the external pallidum, and part of the internal pallidum. PET showed reduced striatal dopa-decarboxylase activity, D2 receptor binding, and glucose metabolism. Perioperative microrecording showed low-frequency activity of STN cells. This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery.</div>
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