Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
Identifieur interne : 004219 ( Main/Merge ); précédent : 004218; suivant : 004220Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
Auteurs : Medeva Ghee [France] ; Alain Fournier [France] ; Jacques Mallet [France]Source :
- Journal of neurochemistry [ 0022-3042 ] ; 2000.
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- Pascal (Inist)
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- topic : Génétique.
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Abstract
The α-synuclein gene, which encodes a brain presynaptic nerve terminal protein of unknown function, is linked to familial early-onset Parkinson's disease (PD). The finding that α-synuclein forms the major fibrillary component of Lewy bodies in brains of PD patients suggests that the two point mutations in α-synuclein (Ala53Thr, Ala30Pro) may promote the aggregation of α-synuclein into filaments. To address the role of α-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat α-synuclein 2 (aSYN2). Here we report that aSYN2 interacts specifically with Tat binding protein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome.
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i1="02"><s1>Aventis Pharma Research and Development</s1><s2>Vitry-Sur-Seine</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Vitry-Sur-Seine</wicri:noRegion><wicri:noRegion>Aventis Pharma Research and Development</wicri:noRegion><wicri:noRegion>Aventis Pharma Research and Development</wicri:noRegion></affiliation></author><author><name sortKey="Mallet, Jacques" sort="Mallet, Jacques" uniqKey="Mallet J" first="Jacques" last="Mallet">Jacques Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, UMR9923, Hôpital de la Pitié Sâlpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement 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Ghee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, UMR9923, Hôpital de la Pitié Sâlpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Aventis Pharma Research and Development</s1><s2>Vitry-Sur-Seine</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Vitry-Sur-Seine</wicri:noRegion><wicri:noRegion>Aventis Pharma Research and Development</wicri:noRegion><wicri:noRegion>Aventis Pharma Research and Development</wicri:noRegion></affiliation></author><author><name sortKey="Mallet, Jacques" sort="Mallet, Jacques" uniqKey="Mallet J" first="Jacques" last="Mallet">Jacques Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, UMR9923, Hôpital de la Pitié Sâlpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neurochemistry</title><title level="j" type="abbreviated">J. neurochem.</title><idno type="ISSN">0022-3042</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurochemistry</title><title level="j" type="abbreviated">J. neurochem.</title><idno type="ISSN">0022-3042</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding protein</term><term>Genetics</term><term>Multicatalytic endopeptidase complex</term><term>Mutation</term><term>Parkinson disease</term><term>Yeast</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mutation</term><term>Protéine liaison</term><term>Génétique</term><term>Multicatalytic endopeptidase complex</term><term>Parkinson maladie</term><term>Levure</term><term>α-Synucléine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The α-synuclein gene, which encodes a brain presynaptic nerve terminal protein of unknown function, is linked to familial early-onset Parkinson's disease (PD). The finding that α-synuclein forms the major fibrillary component of Lewy bodies in brains of PD patients suggests that the two point mutations in α-synuclein (Ala<sup>53</sup>Thr, Ala<sup>30</sup>Pro) may promote the aggregation of α-synuclein into filaments. To address the role of α-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat α-synuclein 2 (aSYN2). Here we report that aSYN2 interacts specifically with Tat binding protein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Ghee, Medeva" sort="Ghee, Medeva" uniqKey="Ghee M" first="Medeva" last="Ghee">Medeva Ghee</name></region><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><name sortKey="Mallet, Jacques" sort="Mallet, Jacques" uniqKey="Mallet J" first="Jacques" last="Mallet">Jacques Mallet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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