Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
Identifieur interne : 000163 ( PascalFrancis/Curation ); précédent : 000162; suivant : 000164Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
Auteurs : Medeva Ghee [France] ; Alain Fournier [France] ; Jacques Mallet [France]Source :
- Journal of neurochemistry [ 0022-3042 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique.
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- KwdEn :
Abstract
The α-synuclein gene, which encodes a brain presynaptic nerve terminal protein of unknown function, is linked to familial early-onset Parkinson's disease (PD). The finding that α-synuclein forms the major fibrillary component of Lewy bodies in brains of PD patients suggests that the two point mutations in α-synuclein (Ala53Thr, Ala30Pro) may promote the aggregation of α-synuclein into filaments. To address the role of α-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat α-synuclein 2 (aSYN2). Here we report that aSYN2 interacts specifically with Tat binding protein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome.
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<front><div type="abstract" xml:lang="en">The α-synuclein gene, which encodes a brain presynaptic nerve terminal protein of unknown function, is linked to familial early-onset Parkinson's disease (PD). The finding that α-synuclein forms the major fibrillary component of Lewy bodies in brains of PD patients suggests that the two point mutations in α-synuclein (Ala<sup>53</sup>
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Pro) may promote the aggregation of α-synuclein into filaments. To address the role of α-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat α-synuclein 2 (aSYN2). Here we report that aSYN2 interacts specifically with Tat binding protein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome.</div>
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