Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease.
Identifieur interne : 003241 ( Main/Merge ); précédent : 003240; suivant : 003242Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease.
Auteurs : Christophe Jollivet [France] ; Anne Aubert-Pouessel ; Anne Clavreul ; Marie-Claire Venier-Julienne ; Claudia N. Montero-Menei ; Jean-Pierre Benoit ; Philippe MeneiSource :
- Neuroscience letters [ 0304-3940 ] ; 2004.
English descriptors
- KwdEn :
- Amphetamine, Analysis of Variance, Animals, Behavior, Animal, Cell Count (methods), Corpus Striatum (anatomy & histology), Corpus Striatum (drug effects), Disease Models, Animal, Female, Glial Cell Line-Derived Neurotrophic Factor, Immunohistochemistry (methods), Microspheres, Nerve Growth Factors (therapeutic use), Nerve Regeneration (drug effects), Oxidopamine, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Rats, Rats, Sprague-Dawley, Stereotaxic Techniques, Stereotyped Behavior (drug effects), Time, Time Factors, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , therapeutic use : Nerve Growth Factors.
- chemical : Amphetamine, Glial Cell Line-Derived Neurotrophic Factor, Oxidopamine.
- anatomy & histology : Corpus Striatum.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Corpus Striatum, Nerve Regeneration, Stereotyped Behavior.
- drug therapy : Parkinson Disease, Secondary.
- methods : Cell Count, Immunohistochemistry.
- Analysis of Variance, Animals, Behavior, Animal, Disease Models, Animal, Female, Microspheres, Rats, Rats, Sprague-Dawley, Stereotaxic Techniques, Time, Time Factors.
Abstract
Glial cell line-derived neurotrophic factor (GDNF) offers the possibility to stimulate axonal regeneration of mesencephalic dopaminergic neurons, which are affected in Parkinson's disease. Nevertheless, a safe and efficient GDNF delivery system that may be used in clinical trials is still lacking. In a previous study, we showed that GDNF-releasing microspheres can deliver the neurotrophic factor for 2 months, allowing in a partial rat model of Parkinson's disease a sprouting of the preserved dopaminergic fibers and functional improvement 8 weeks after the treatment. The present study confirms these previous observations and shows that the amphetamine-induced rotation score is still decreased 24 weeks after the end of GDNF delivery. Nevertheless, the improvement was not statistically significant at the latest time point due to the spontaneous reinnervation observed in the model used.
DOI: 10.1016/j.neulet.2003.11.051
PubMed: 15036631
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pubmed:15036631Le document en format XML
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<term>Stereotyped Behavior (drug effects)</term>
<term>Time</term>
<term>Time Factors</term>
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<front><div type="abstract" xml:lang="en">Glial cell line-derived neurotrophic factor (GDNF) offers the possibility to stimulate axonal regeneration of mesencephalic dopaminergic neurons, which are affected in Parkinson's disease. Nevertheless, a safe and efficient GDNF delivery system that may be used in clinical trials is still lacking. In a previous study, we showed that GDNF-releasing microspheres can deliver the neurotrophic factor for 2 months, allowing in a partial rat model of Parkinson's disease a sprouting of the preserved dopaminergic fibers and functional improvement 8 weeks after the treatment. The present study confirms these previous observations and shows that the amphetamine-induced rotation score is still decreased 24 weeks after the end of GDNF delivery. Nevertheless, the improvement was not statistically significant at the latest time point due to the spontaneous reinnervation observed in the model used.</div>
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