Motor signs during the course of Alzheimer disease
Identifieur interne : 003240 ( Main/Merge ); précédent : 003239; suivant : 003241Motor signs during the course of Alzheimer disease
Auteurs : N. Scarmeas ; G. M. Hadjigeorgiou ; A. Papadimitriou ; B. Dubois ; M. Sarazin ; J. Brandt ; M. Albert ; K. Marder ; K. Bell ; L. S. Honig ; D. Wegesin ; Y. SternSource :
- Neurology [ 0028-3878 ] ; 2004.
Abstract
Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care.
To describe the progression and identify predictors of individual MOSIs in AD.
A cohort of 474 patients with AD at early stages was followed semiannually for up to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits/assessments of MOSIs (average 6.4/patient) were performed. Prevalence and incidence rates were calculated, and cumulative risk graphs were plotted for individual non-drug-induced MOSI domains. Rates of change over time taking into account potential covariates were also estimated. With use of each MOSI domain as outcome in Cox models, predictors of MOSI incidence were identified.
At least one MOSI was detected in 13% of patients at first examination and in 36% for the last evaluation. Total MOSI score increased at an annual rate of 3% of total possible score. Rates of annual change for speech/facial expression (4%), rigidity (2.45%), posture/gait (3.9%), and bradykinesia (3.75%) were of similar magnitude, and their occurrence increased from first (3 to 6%) to last (22 to 29%) evaluation. Tremor was less frequent throughout the course of the disease (4% at first and 7% at last evaluation) and worsened less (0.75% increase/year).
Most motor signs occur frequently and progress rapidly in Alzheimer disease. Tremor is an exception in that it occurs less frequently and advances at slower rates.
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PubMed: 15452286
PubMed Central: 3028531
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Motor signs during the course of Alzheimer disease</title><author><name sortKey="Scarmeas, N" sort="Scarmeas, N" uniqKey="Scarmeas N" first="N." last="Scarmeas">N. Scarmeas</name></author><author><name sortKey="Hadjigeorgiou, G M" sort="Hadjigeorgiou, G M" uniqKey="Hadjigeorgiou G" first="G. M." last="Hadjigeorgiou">G. M. Hadjigeorgiou</name></author><author><name sortKey="Papadimitriou, A" sort="Papadimitriou, A" uniqKey="Papadimitriou A" first="A." last="Papadimitriou">A. Papadimitriou</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name></author><author><name sortKey="Sarazin, M" sort="Sarazin, M" uniqKey="Sarazin M" first="M." last="Sarazin">M. Sarazin</name></author><author><name sortKey="Brandt, J" sort="Brandt, J" uniqKey="Brandt J" first="J." last="Brandt">J. Brandt</name></author><author><name sortKey="Albert, M" sort="Albert, M" uniqKey="Albert M" first="M." last="Albert">M. Albert</name></author><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K." last="Marder">K. Marder</name></author><author><name sortKey="Bell, K" sort="Bell, K" uniqKey="Bell K" first="K." last="Bell">K. Bell</name></author><author><name sortKey="Honig, L S" sort="Honig, L S" uniqKey="Honig L" first="L. S." last="Honig">L. S. Honig</name></author><author><name sortKey="Wegesin, D" sort="Wegesin, D" uniqKey="Wegesin D" first="D." last="Wegesin">D. Wegesin</name></author><author><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15452286</idno><idno type="pmc">3028531</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028531</idno><idno type="RBID">PMC:3028531</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000366</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000366</idno><idno type="wicri:Area/Pmc/Curation">000363</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000363</idno><idno type="wicri:Area/Pmc/Checkpoint">000919</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000919</idno><idno type="wicri:Area/Ncbi/Merge">000470</idno><idno type="wicri:Area/Ncbi/Curation">000470</idno><idno type="wicri:Area/Ncbi/Checkpoint">000470</idno><idno type="wicri:doubleKey">0028-3878:2004:Scarmeas N:motor:signs:during</idno><idno type="wicri:Area/Main/Merge">003240</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Motor signs during the course of Alzheimer disease</title><author><name sortKey="Scarmeas, N" sort="Scarmeas, N" uniqKey="Scarmeas N" first="N." last="Scarmeas">N. Scarmeas</name></author><author><name sortKey="Hadjigeorgiou, G M" sort="Hadjigeorgiou, G M" uniqKey="Hadjigeorgiou G" first="G. M." last="Hadjigeorgiou">G. M. Hadjigeorgiou</name></author><author><name sortKey="Papadimitriou, A" sort="Papadimitriou, A" uniqKey="Papadimitriou A" first="A." last="Papadimitriou">A. Papadimitriou</name></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name></author><author><name sortKey="Sarazin, M" sort="Sarazin, M" uniqKey="Sarazin M" first="M." last="Sarazin">M. Sarazin</name></author><author><name sortKey="Brandt, J" sort="Brandt, J" uniqKey="Brandt J" first="J." last="Brandt">J. Brandt</name></author><author><name sortKey="Albert, M" sort="Albert, M" uniqKey="Albert M" first="M." last="Albert">M. Albert</name></author><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K." last="Marder">K. Marder</name></author><author><name sortKey="Bell, K" sort="Bell, K" uniqKey="Bell K" first="K." last="Bell">K. Bell</name></author><author><name sortKey="Honig, L S" sort="Honig, L S" uniqKey="Honig L" first="L. S." last="Honig">L. S. Honig</name></author><author><name sortKey="Wegesin, D" sort="Wegesin, D" uniqKey="Wegesin D" first="D." last="Wegesin">D. Wegesin</name></author><author><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To describe the progression and identify predictors of individual MOSIs in AD.</p></sec><sec sec-type="methods" id="S3"><title>Methods</title><p id="P3">A cohort of 474 patients with AD at early stages was followed semiannually for up to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits/assessments of MOSIs (average 6.4/patient) were performed. Prevalence and incidence rates were calculated, and cumulative risk graphs were plotted for individual non-drug-induced MOSI domains. Rates of change over time taking into account potential covariates were also estimated. With use of each MOSI domain as outcome in Cox models, predictors of MOSI incidence were identified.</p></sec><sec id="S4"><title>Results</title><p id="P4">At least one MOSI was detected in 13% of patients at first examination and in 36% for the last evaluation. Total MOSI score increased at an annual rate of 3% of total possible score. Rates of annual change for speech/facial expression (4%), rigidity (2.45%), posture/gait (3.9%), and bradykinesia (3.75%) were of similar magnitude, and their occurrence increased from first (3 to 6%) to last (22 to 29%) evaluation. Tremor was less frequent throughout the course of the disease (4% at first and 7% at last evaluation) and worsened less (0.75% increase/year).</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Most motor signs occur frequently and progress rapidly in Alzheimer disease. Tremor is an exception in that it occurs less frequently and advances at slower rates.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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