Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method
Identifieur interne : 003157 ( Main/Merge ); précédent : 003156; suivant : 003158Does subthalamic nucleus stimulation affect the frontal limbic areas? A single-photon emission computed tomography study using a manual anatomical segmentation method
Auteurs : C. Haegelen [France] ; M. Verin [France] ; B. Aubert Broche [France] ; F. Prigent [France] ; P. Jannin [France] ; B. Gibaud [France] ; X. Morandi [France]Source :
- Surgical and radiologic anatomy : (Print) [ 0930-1038 ] ; 2005.
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Abstract
Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.
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A single-photon emission computed tomography study using a manual anatomical segmentation method</title><author><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Neurochirurgie, Hôpital Pontchaillou, rue Henri Le Guilloux</s1><s2>35033 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M." last="Verin">M. Verin</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital Pontchaillou, rue Henri Le Guilloux</s1><s2>35033 Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Broche, B Aubert" sort="Broche, B Aubert" uniqKey="Broche B" first="B. Aubert" last="Broche">B. Aubert Broche</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Prigent, F" sort="Prigent, F" uniqKey="Prigent F" first="F." last="Prigent">F. Prigent</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Département de Médecine Nucléaire, Centre Eugène Marquis, Avenue Bataille Flandres-Dunkerque</s1><s2>35042 Rennes</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Jannin, P" sort="Jannin, P" uniqKey="Jannin P" first="P." last="Jannin">P. Jannin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Gibaud, B" sort="Gibaud, B" uniqKey="Gibaud B" first="B." last="Gibaud">B. Gibaud</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X." last="Morandi">X. Morandi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard. Laboratoire IDM-UPRES-EA3192</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Faculté de Médecine de Rennes, Avenue du Professeur Léon Bernard, Laboratoire d'Anatomie et d'Organogenèse</s1><s2>35043 Rennes</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Surgical and radiologic anatomy : (Print)</title><title level="j" type="abbreviated">Surg. radiol. anat. : (Print)</title><idno type="ISSN">0930-1038</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Surgical and radiologic anatomy : (Print)</title><title level="j" type="abbreviated">Surg. radiol. anat. : (Print)</title><idno type="ISSN">0930-1038</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain</term><term>Encephalon</term><term>Frontal</term><term>Limbic system</term><term>Manuals</term><term>Medicine</term><term>Method</term><term>Methodology</term><term>Nuclear magnetic resonance imaging</term><term>Segmentation</term><term>Single photon emission tomography</term><term>Stimulation</term><term>Subthalamic nucleus</term><term>Surgery</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Noyau sousthalamique</term><term>Stimulation</term><term>Frontal</term><term>Tomoscintigraphie émission monophotonique</term><term>Manuel</term><term>Segmentation</term><term>Méthodologie</term><term>Méthode</term><term>Encéphale</term><term>Cerveau</term><term>Système limbique</term><term>Imagerie RMN</term><term>Médecine</term><term>Chirurgie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Among the basal ganglia nuclei, the subthalamic nucleus (STN) is considered to play a major role in output modulation. The STN represents a relay of the motor cortico-basal ganglia-thalamo-cortical circuit and has become the standard surgical target for treating Parkinson's patients with long-term motor fluctuations and dyskinesia. But chronic bilateral stimulation of the STN produces cognitive effects. According to animal and clinical studies, the STN also appears to have direct or indirect connections with the frontal associative and limbic areas. This prospective study was conducted to analyse regional cerebral blood flow changes in single-photon emission computed tomography imaging of six Parkinson's patients before and after STN stimulation. We particularly focused on the dorsolateral prefrontal cortex and the frontal limbic areas using a manual anatomical MRI segmentation method. We defined nine regions of interest, segmenting each MR slice to quantify the regional cerebral blood flow on pre- and postoperative SPECT images. We normalised the region-of-interest-based measurements to the entire brain volume. The, patients showed increased activation during STN stimulation in the dorsolateral prefrontal cortex bilaterally and no change in the anterior cingulate and orbitofrontal cortices. In our study, STN stimulation induced activation of premotor and associative frontal areas. Further studies are needed to underline involvement of the STN with the so-called limbic system.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name></region><name sortKey="Broche, B Aubert" sort="Broche, B Aubert" uniqKey="Broche B" first="B. Aubert" last="Broche">B. Aubert Broche</name><name sortKey="Gibaud, B" sort="Gibaud, B" uniqKey="Gibaud B" first="B." last="Gibaud">B. Gibaud</name><name sortKey="Haegelen, C" sort="Haegelen, C" uniqKey="Haegelen C" first="C." last="Haegelen">C. Haegelen</name><name sortKey="Jannin, P" sort="Jannin, P" uniqKey="Jannin P" first="P." last="Jannin">P. Jannin</name><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X." last="Morandi">X. Morandi</name><name sortKey="Morandi, X" sort="Morandi, X" uniqKey="Morandi X" first="X." last="Morandi">X. Morandi</name><name sortKey="Prigent, F" sort="Prigent, F" uniqKey="Prigent F" first="F." last="Prigent">F. Prigent</name><name sortKey="Verin, M" sort="Verin, M" uniqKey="Verin M" first="M." last="Verin">M. Verin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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