La maladie de Parkinson en France (serveur d'exploration)

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Manic behaviour induced by deep-brain stimulation in Parkinson's disease : evidence of substantia nigra implication?

Identifieur interne : 002E39 ( Main/Merge ); précédent : 002E38; suivant : 002E40

Manic behaviour induced by deep-brain stimulation in Parkinson's disease : evidence of substantia nigra implication?

Auteurs : M. Ulla [France] ; S. Thobois [France] ; J.-J. Lemaire [France] ; A. Schmitt [France] ; P. Derost [France] ; E. Broussolle [France] ; P.-M. Llorca [France] ; F. Durif [France]

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RBID : Pascal:06-0529845

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Abstract

We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.

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Pascal:06-0529845

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<div type="abstract" xml:lang="en">We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.</div>
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