Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration.
Identifieur interne : 002040 ( Main/Merge ); précédent : 002039; suivant : 002041Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration.
Auteurs : Sarah Vautier [France] ; Aline Milane ; Christine Fernandez ; Helene Chacun ; Lucette Lacomblez ; Robert FarinottiSource :
- Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [ 1482-1826 ] ; 2009.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, ATP Binding Cassette Transporter, Sub-Family G, Member 2, ATP-Binding Cassette Transporters (genetics), ATP-Binding Cassette Transporters (metabolism), Animals, Antiparkinson Agents (pharmacokinetics), Biological Transport, Blood-Brain Barrier (metabolism), Blotting, Western, Brain (metabolism), Bromocriptine (pharmacokinetics), Disease Models, Animal, Gene Expression Regulation, Injections, Intraperitoneal, MPTP Poisoning (physiopathology), Male, Mice, Mice, Inbred C57BL, P-Glycoprotein, P-Glycoproteins, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Tissue Distribution.
- MESH :
- chemical , pharmacokinetics : Antiparkinson Agents, Bromocriptine.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, ATP Binding Cassette Transporter, Sub-Family G, Member 2, P-Glycoprotein, P-Glycoproteins.
- drug therapy : Parkinson Disease.
- genetics : ATP-Binding Cassette Transporters.
- metabolism : ATP-Binding Cassette Transporters, Blood-Brain Barrier, Brain.
- physiopathology : MPTP Poisoning, Parkinson Disease.
- Animals, Biological Transport, Blotting, Western, Disease Models, Animal, Gene Expression Regulation, Injections, Intraperitoneal, Male, Mice, Mice, Inbred C57BL, Tissue Distribution.
Abstract
MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported.
PubMed: 19732497
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pubmed:19732497Le document en format XML
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<author><name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name>
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<front><div type="abstract" xml:lang="en">MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported.</div>
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