Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration.
Identifieur interne : 002040 ( Main/Merge ); précédent : 002039; suivant : 002041Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration.
Auteurs : Sarah Vautier [France] ; Aline Milane ; Christine Fernandez ; Helene Chacun ; Lucette Lacomblez ; Robert FarinottiSource :
- Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [ 1482-1826 ] ; 2009.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, ATP Binding Cassette Transporter, Sub-Family G, Member 2, ATP-Binding Cassette Transporters (genetics), ATP-Binding Cassette Transporters (metabolism), Animals, Antiparkinson Agents (pharmacokinetics), Biological Transport, Blood-Brain Barrier (metabolism), Blotting, Western, Brain (metabolism), Bromocriptine (pharmacokinetics), Disease Models, Animal, Gene Expression Regulation, Injections, Intraperitoneal, MPTP Poisoning (physiopathology), Male, Mice, Mice, Inbred C57BL, P-Glycoprotein, P-Glycoproteins, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Tissue Distribution.
- MESH :
- chemical , pharmacokinetics : Antiparkinson Agents, Bromocriptine.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, ATP Binding Cassette Transporter, Sub-Family G, Member 2, P-Glycoprotein, P-Glycoproteins.
- drug therapy : Parkinson Disease.
- genetics : ATP-Binding Cassette Transporters.
- metabolism : ATP-Binding Cassette Transporters, Blood-Brain Barrier, Brain.
- physiopathology : MPTP Poisoning, Parkinson Disease.
- Animals, Biological Transport, Blotting, Western, Disease Models, Animal, Gene Expression Regulation, Injections, Intraperitoneal, Male, Mice, Mice, Inbred C57BL, Tissue Distribution.
Abstract
MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported.
PubMed: 19732497
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pubmed:19732497Le document en format XML
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sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name></author><author><name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name></author><author><name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19732497</idno><idno type="pmid">19732497</idno><idno type="wicri:Area/PubMed/Corpus">000C36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C36</idno><idno type="wicri:Area/PubMed/Curation">000B96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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Clinical Pharmacy EA 2706, University Paris Sud XI, Chatenay-Malabry</wicri:regionArea><wicri:noRegion>Chatenay-Malabry</wicri:noRegion><wicri:noRegion>Chatenay-Malabry</wicri:noRegion></affiliation></author><author><name sortKey="Milane, Aline" sort="Milane, Aline" uniqKey="Milane A" first="Aline" last="Milane">Aline Milane</name></author><author><name sortKey="Fernandez, Christine" sort="Fernandez, Christine" uniqKey="Fernandez C" first="Christine" last="Fernandez">Christine Fernandez</name></author><author><name sortKey="Chacun, Helene" sort="Chacun, Helene" uniqKey="Chacun H" first="Helene" last="Chacun">Helene Chacun</name></author><author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name></author><author><name sortKey="Farinotti, Robert" sort="Farinotti, Robert" uniqKey="Farinotti R" first="Robert" last="Farinotti">Robert Farinotti</name></author></analytic><series><title level="j">Journal 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Transporters</term><term>Blood-Brain Barrier</term><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>MPTP Poisoning</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Transport</term><term>Blotting, Western</term><term>Disease Models, Animal</term><term>Gene Expression Regulation</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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