Piperazine derivatives as iron chelators: a potential application in neurobiology.
Identifieur interne : 000543 ( Main/Merge ); précédent : 000542; suivant : 000544Piperazine derivatives as iron chelators: a potential application in neurobiology.
Auteurs : S. Abdelsayed [France] ; N T Ha Duong ; C. Bureau ; P P Michel ; E C Hirsch ; J M El Hage Chahine ; N. SerradjiSource :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [ 1572-8773 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Chlorides (antagonists & inhibitors), Chlorides (pharmacology), Dopaminergic Neurons (cytology), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (metabolism), Embryo, Mammalian, Ferric Compounds (antagonists & inhibitors), Ferric Compounds (pharmacology), Hydrogen-Ion Concentration, Iron Chelating Agents (chemical synthesis), Iron Chelating Agents (pharmacology), Kinetics, Mesencephalon (cytology), Mesencephalon (drug effects), Mesencephalon (metabolism), Neuroprotective Agents (chemical synthesis), Neuroprotective Agents (pharmacology), Piperazines (chemical synthesis), Piperazines (pharmacology), Primary Cell Culture, Rats, Rats, Wistar, Thermodynamics.
- MESH :
- chemical , antagonists & inhibitors : Chlorides, Ferric Compounds.
- chemical , chemical synthesis : Iron Chelating Agents, Neuroprotective Agents, Piperazines.
- chemical , pharmacology : Chlorides, Ferric Compounds, Iron Chelating Agents, Neuroprotective Agents, Piperazines.
- cytology : Dopaminergic Neurons, Mesencephalon.
- drug effects : Dopaminergic Neurons, Mesencephalon.
- metabolism : Dopaminergic Neurons, Mesencephalon.
- Animals, Embryo, Mammalian, Hydrogen-Ion Concentration, Kinetics, Primary Cell Culture, Rats, Rats, Wistar, Thermodynamics.
Abstract
Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.
DOI: 10.1007/s10534-015-9889-x
PubMed: 26502356
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000242
- to stream PubMed, to step Curation: 000241
- to stream PubMed, to step Checkpoint: 000241
- to stream Ncbi, to step Merge: 001859
- to stream Ncbi, to step Curation: 001859
- to stream Ncbi, to step Checkpoint: 001859
Links to Exploration step
pubmed:26502356Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Piperazine derivatives as iron chelators: a potential application in neurobiology.</title>
<author><name sortKey="Abdelsayed, S" sort="Abdelsayed, S" uniqKey="Abdelsayed S" first="S" last="Abdelsayed">S. Abdelsayed</name>
<affiliation wicri:level="3"><nlm:affiliation>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13, France</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duong, N T Ha" sort="Duong, N T Ha" uniqKey="Duong N" first="N T Ha" last="Duong">N T Ha Duong</name>
</author>
<author><name sortKey="Bureau, C" sort="Bureau, C" uniqKey="Bureau C" first="C" last="Bureau">C. Bureau</name>
</author>
<author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P P" last="Michel">P P Michel</name>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name>
</author>
<author><name sortKey="Chahine, J M El Hage" sort="Chahine, J M El Hage" uniqKey="Chahine J" first="J M El Hage" last="Chahine">J M El Hage Chahine</name>
</author>
<author><name sortKey="Serradji, N" sort="Serradji, N" uniqKey="Serradji N" first="N" last="Serradji">N. Serradji</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26502356</idno>
<idno type="pmid">26502356</idno>
<idno type="doi">10.1007/s10534-015-9889-x</idno>
<idno type="wicri:Area/PubMed/Corpus">000242</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000242</idno>
<idno type="wicri:Area/PubMed/Curation">000241</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000241</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000241</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000241</idno>
<idno type="wicri:Area/Ncbi/Merge">001859</idno>
<idno type="wicri:Area/Ncbi/Curation">001859</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001859</idno>
<idno type="wicri:Area/Main/Merge">000543</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Piperazine derivatives as iron chelators: a potential application in neurobiology.</title>
<author><name sortKey="Abdelsayed, S" sort="Abdelsayed, S" uniqKey="Abdelsayed S" first="S" last="Abdelsayed">S. Abdelsayed</name>
<affiliation wicri:level="3"><nlm:affiliation>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13, France</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duong, N T Ha" sort="Duong, N T Ha" uniqKey="Duong N" first="N T Ha" last="Duong">N T Ha Duong</name>
</author>
<author><name sortKey="Bureau, C" sort="Bureau, C" uniqKey="Bureau C" first="C" last="Bureau">C. Bureau</name>
</author>
<author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P P" last="Michel">P P Michel</name>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name>
</author>
<author><name sortKey="Chahine, J M El Hage" sort="Chahine, J M El Hage" uniqKey="Chahine J" first="J M El Hage" last="Chahine">J M El Hage Chahine</name>
</author>
<author><name sortKey="Serradji, N" sort="Serradji, N" uniqKey="Serradji N" first="N" last="Serradji">N. Serradji</name>
</author>
</analytic>
<series><title level="j">Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine</title>
<idno type="eISSN">1572-8773</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chlorides (antagonists & inhibitors)</term>
<term>Chlorides (pharmacology)</term>
<term>Dopaminergic Neurons (cytology)</term>
<term>Dopaminergic Neurons (drug effects)</term>
<term>Dopaminergic Neurons (metabolism)</term>
<term>Embryo, Mammalian</term>
<term>Ferric Compounds (antagonists & inhibitors)</term>
<term>Ferric Compounds (pharmacology)</term>
<term>Hydrogen-Ion Concentration</term>
<term>Iron Chelating Agents (chemical synthesis)</term>
<term>Iron Chelating Agents (pharmacology)</term>
<term>Kinetics</term>
<term>Mesencephalon (cytology)</term>
<term>Mesencephalon (drug effects)</term>
<term>Mesencephalon (metabolism)</term>
<term>Neuroprotective Agents (chemical synthesis)</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Piperazines (chemical synthesis)</term>
<term>Piperazines (pharmacology)</term>
<term>Primary Cell Culture</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Thermodynamics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Chlorides</term>
<term>Ferric Compounds</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Iron Chelating Agents</term>
<term>Neuroprotective Agents</term>
<term>Piperazines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chlorides</term>
<term>Ferric Compounds</term>
<term>Iron Chelating Agents</term>
<term>Neuroprotective Agents</term>
<term>Piperazines</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dopaminergic Neurons</term>
<term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dopaminergic Neurons</term>
<term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term>
<term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Embryo, Mammalian</term>
<term>Hydrogen-Ion Concentration</term>
<term>Kinetics</term>
<term>Primary Cell Culture</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Thermodynamics</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000543 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000543 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Merge |type= RBID |clé= pubmed:26502356 |texte= Piperazine derivatives as iron chelators: a potential application in neurobiology. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:26502356" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |