Piperazine derivatives as iron chelators: a potential application in neurobiology.
Identifieur interne : 001859 ( Ncbi/Curation ); précédent : 001858; suivant : 001860Piperazine derivatives as iron chelators: a potential application in neurobiology.
Auteurs : S. Abdelsayed [France] ; N T Ha Duong ; C. Bureau ; P P Michel ; E C Hirsch ; J M El Hage Chahine ; N. SerradjiSource :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [ 1572-8773 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Chlorides (antagonists & inhibitors), Chlorides (pharmacology), Dopaminergic Neurons (cytology), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (metabolism), Embryo, Mammalian, Ferric Compounds (antagonists & inhibitors), Ferric Compounds (pharmacology), Hydrogen-Ion Concentration, Iron Chelating Agents (chemical synthesis), Iron Chelating Agents (pharmacology), Kinetics, Mesencephalon (cytology), Mesencephalon (drug effects), Mesencephalon (metabolism), Neuroprotective Agents (chemical synthesis), Neuroprotective Agents (pharmacology), Piperazines (chemical synthesis), Piperazines (pharmacology), Primary Cell Culture, Rats, Rats, Wistar, Thermodynamics.
- MESH :
- chemical , antagonists & inhibitors : Chlorides, Ferric Compounds.
- chemical , chemical synthesis : Iron Chelating Agents, Neuroprotective Agents, Piperazines.
- chemical , pharmacology : Chlorides, Ferric Compounds, Iron Chelating Agents, Neuroprotective Agents, Piperazines.
- cytology : Dopaminergic Neurons, Mesencephalon.
- drug effects : Dopaminergic Neurons, Mesencephalon.
- metabolism : Dopaminergic Neurons, Mesencephalon.
- Animals, Embryo, Mammalian, Hydrogen-Ion Concentration, Kinetics, Primary Cell Culture, Rats, Rats, Wistar, Thermodynamics.
Abstract
Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.
DOI: 10.1007/s10534-015-9889-x
PubMed: 26502356
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pubmed:26502356Le document en format XML
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Abdelsayed</name><affiliation wicri:level="3"><nlm:affiliation>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13, France</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duong, N T Ha" sort="Duong, N T Ha" uniqKey="Duong N" first="N T Ha" last="Duong">N T Ha Duong</name></author><author><name sortKey="Bureau, C" sort="Bureau, C" uniqKey="Bureau C" first="C" last="Bureau">C. Bureau</name></author><author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P P" last="Michel">P P Michel</name></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name></author><author><name sortKey="Chahine, J M El Hage" sort="Chahine, J M El Hage" uniqKey="Chahine J" first="J M El Hage" last="Chahine">J M El Hage Chahine</name></author><author><name sortKey="Serradji, N" sort="Serradji, N" uniqKey="Serradji N" first="N" last="Serradji">N. Serradji</name></author></analytic><series><title level="j">Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine</title><idno type="eISSN">1572-8773</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorides (antagonists & inhibitors)</term><term>Chlorides (pharmacology)</term><term>Dopaminergic Neurons (cytology)</term><term>Dopaminergic Neurons (drug effects)</term><term>Dopaminergic Neurons (metabolism)</term><term>Embryo, Mammalian</term><term>Ferric Compounds (antagonists & inhibitors)</term><term>Ferric Compounds (pharmacology)</term><term>Hydrogen-Ion Concentration</term><term>Iron Chelating Agents (chemical synthesis)</term><term>Iron Chelating Agents (pharmacology)</term><term>Kinetics</term><term>Mesencephalon (cytology)</term><term>Mesencephalon (drug effects)</term><term>Mesencephalon (metabolism)</term><term>Neuroprotective Agents (chemical synthesis)</term><term>Neuroprotective Agents (pharmacology)</term><term>Piperazines (chemical synthesis)</term><term>Piperazines (pharmacology)</term><term>Primary Cell Culture</term><term>Rats</term><term>Rats, Wistar</term><term>Thermodynamics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Chlorides</term><term>Ferric Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Iron Chelating Agents</term><term>Neuroprotective Agents</term><term>Piperazines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chlorides</term><term>Ferric Compounds</term><term>Iron Chelating Agents</term><term>Neuroprotective Agents</term><term>Piperazines</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dopaminergic Neurons</term><term>Mesencephalon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dopaminergic Neurons</term><term>Mesencephalon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Embryo, Mammalian</term><term>Hydrogen-Ion Concentration</term><term>Kinetics</term><term>Primary Cell Culture</term><term>Rats</term><term>Rats, Wistar</term><term>Thermodynamics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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