Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?
Identifieur interne : 000242 ( Main/Merge ); précédent : 000241; suivant : 000243Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?
Auteurs : Lucie Hopes [France] ; Guillaume Grolez [France] ; Caroline Moreau [France] ; Renaud Lopes [France] ; Gilles Ryckewaert [France] ; Nicolas Carrière [France] ; Florent Auger [France] ; Charlotte Laloux [France] ; Maud Petrault [France] ; Jean-Christophe Devedjian [France] ; Regis Bordet [France] ; Luc Defebvre [France] ; Patrice Jissendi [France] ; Christine Delmaire [France] ; David Devos [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Acute Disease, Aged, Animals, Biomarkers (analysis), Corpus Striatum (pathology), Cross-Sectional Studies, Female, Humans, Iron (analysis), Iron Overload (complications), Magnetic Resonance Imaging (methods), Male, Mice, Inbred C57BL, Middle Aged, Oxidative Stress, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease, Secondary (complications), Parkinson Disease, Secondary (pathology), Substantia Nigra (pathology).
- MESH :
- chemical , analysis : Biomarkers, Iron.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- complications : Iron Overload, Parkinson Disease, Parkinson Disease, Secondary.
- methods : Magnetic Resonance Imaging.
- pathology : Corpus Striatum, Parkinson Disease, Parkinson Disease, Secondary, Substantia Nigra.
- Acute Disease, Aged, Animals, Cross-Sectional Studies, Female, Humans, Male, Mice, Inbred C57BL, Middle Aged, Oxidative Stress.
Abstract
Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson’s disease (PD); R2* values reflect iron content related to high levels of oxidative stress, whereas volume and/or shape changes reflect neuronal death. We sought to assess iron overload in the nigrostriatal system and characterize its relationship with focal and overall atrophy of the striatum in the pivotal stages of PD.
Twenty controls and 70 PD patients at different disease stages (untreated
The R2* values in the substantia nigra, putamen and caudate nucleus were significantly higher in
Each pivotal stage in PD appears to be characterized by putative nigrostriatal MRI biomarkers: iron overload at the
Url:
DOI: 10.1371/journal.pone.0147947
PubMed: 27035571
PubMed Central: 4818028
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000147
- to stream Pmc, to step Curation: 000147
- to stream Pmc, to step Checkpoint: 000062
- to stream PubMed, to step Corpus: 000171
- to stream PubMed, to step Curation: 000171
- to stream PubMed, to step Checkpoint: 000171
- to stream Ncbi, to step Merge: 001991
- to stream Ncbi, to step Curation: 001991
- to stream Ncbi, to step Checkpoint: 001991
Links to Exploration step
PMC:4818028Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?</title><author><name sortKey="Hopes, Lucie" sort="Hopes, Lucie" uniqKey="Hopes L" first="Lucie" last="Hopes">Lucie Hopes</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Grolez, Guillaume" sort="Grolez, Guillaume" uniqKey="Grolez G" first="Guillaume" last="Grolez">Guillaume Grolez</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lopes, Renaud" sort="Lopes, Renaud" uniqKey="Lopes R" first="Renaud" last="Lopes">Renaud Lopes</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ryckewaert, Gilles" sort="Ryckewaert, Gilles" uniqKey="Ryckewaert G" first="Gilles" last="Ryckewaert">Gilles Ryckewaert</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Carriere, Nicolas" sort="Carriere, Nicolas" uniqKey="Carriere N" first="Nicolas" last="Carrière">Nicolas Carrière</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Auger, Florent" sort="Auger, Florent" uniqKey="Auger F" first="Florent" last="Auger">Florent Auger</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Small Animal Imaging Unit, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Small Animal Imaging Unit, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Laloux, Charlotte" sort="Laloux, Charlotte" uniqKey="Laloux C" first="Charlotte" last="Laloux">Charlotte Laloux</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Petrault, Maud" sort="Petrault, Maud" uniqKey="Petrault M" first="Maud" last="Petrault">Maud Petrault</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devedjian, Jean Christophe" sort="Devedjian, Jean Christophe" uniqKey="Devedjian J" first="Jean-Christophe" last="Devedjian">Jean-Christophe Devedjian</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Jissendi, Patrice" sort="Jissendi, Patrice" uniqKey="Jissendi P" first="Patrice" last="Jissendi">Patrice Jissendi</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27035571</idno><idno type="pmc">4818028</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818028</idno><idno type="RBID">PMC:4818028</idno><idno type="doi">10.1371/journal.pone.0147947</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000147</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000147</idno><idno type="wicri:Area/Pmc/Curation">000147</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000147</idno><idno type="wicri:Area/Pmc/Checkpoint">000062</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000062</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000171</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000171</idno><idno type="wicri:Area/PubMed/Curation">000171</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000171</idno><idno type="wicri:Area/PubMed/Checkpoint">000171</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000171</idno><idno type="wicri:Area/Ncbi/Merge">001991</idno><idno type="wicri:Area/Ncbi/Curation">001991</idno><idno type="wicri:Area/Ncbi/Checkpoint">001991</idno><idno type="wicri:Area/Main/Merge">000242</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?</title><author><name sortKey="Hopes, Lucie" sort="Hopes, Lucie" uniqKey="Hopes L" first="Lucie" last="Hopes">Lucie Hopes</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Grolez, Guillaume" sort="Grolez, Guillaume" uniqKey="Grolez G" first="Guillaume" last="Grolez">Guillaume Grolez</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lopes, Renaud" sort="Lopes, Renaud" uniqKey="Lopes R" first="Renaud" last="Lopes">Renaud Lopes</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ryckewaert, Gilles" sort="Ryckewaert, Gilles" uniqKey="Ryckewaert G" first="Gilles" last="Ryckewaert">Gilles Ryckewaert</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Carriere, Nicolas" sort="Carriere, Nicolas" uniqKey="Carriere N" first="Nicolas" last="Carrière">Nicolas Carrière</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Auger, Florent" sort="Auger, Florent" uniqKey="Auger F" first="Florent" last="Auger">Florent Auger</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Small Animal Imaging Unit, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Small Animal Imaging Unit, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Laloux, Charlotte" sort="Laloux, Charlotte" uniqKey="Laloux C" first="Charlotte" last="Laloux">Charlotte Laloux</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Petrault, Maud" sort="Petrault, Maud" uniqKey="Petrault M" first="Maud" last="Petrault">Maud Petrault</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devedjian, Jean Christophe" sort="Devedjian, Jean Christophe" uniqKey="Devedjian J" first="Jean-Christophe" last="Devedjian">Jean-Christophe Devedjian</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bordet, Regis" sort="Bordet, Regis" uniqKey="Bordet R" first="Regis" last="Bordet">Regis Bordet</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Jissendi, Patrice" sort="Jissendi, Patrice" uniqKey="Jissendi P" first="Patrice" last="Jissendi">Patrice Jissendi</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Neuroradiology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Movement Disorders and Neurology, Lille University Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>INSERM U1171, Faculty of Medicine, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1171, Faculty of Medicine, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Department of Medical Pharmacology, Lille University, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, Lille University, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Acute Disease</term><term>Aged</term><term>Animals</term><term>Biomarkers (analysis)</term><term>Corpus Striatum (pathology)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Iron (analysis)</term><term>Iron Overload (complications)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Middle Aged</term><term>Oxidative Stress</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease, Secondary (complications)</term><term>Parkinson Disease, Secondary (pathology)</term><term>Substantia Nigra (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Iron</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Iron Overload</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Aged</term><term>Animals</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice, Inbred C57BL</term><term>Middle Aged</term><term>Oxidative Stress</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Introduction</title><p>Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson’s disease (PD); R2* values reflect iron content related to high levels of oxidative stress, whereas volume and/or shape changes reflect neuronal death. We sought to assess iron overload in the nigrostriatal system and characterize its relationship with focal and overall atrophy of the striatum in the pivotal stages of PD.</p></sec><sec id="sec002"><title>Methods</title><p>Twenty controls and 70 PD patients at different disease stages (untreated <italic>de novo</italic> patients, treated early-stage patients and advanced-stage patients with L-dopa-related motor complications) were included in the study. We determined the R2* values in the substantia nigra, putamen and caudate nucleus, together with striatal volume and shape analysis. We also measured R2* in an acute MPTP mouse model and in a longitudinal follow-up two years later in the early-stage PD patients.</p></sec><sec id="sec003"><title>Results</title><p>The R2* values in the substantia nigra, putamen and caudate nucleus were significantly higher in <italic>de novo</italic> PD patients than in controls. Early-stage patients displayed significantly higher R2* values in the substantia nigra (with changes in striatal shape), relative to <italic>de novo</italic> patients. Measurements after a two-year follow-up in early-stage patients and characterization of the acute MPTP mouse model confirmed that R2* changed rapidly with disease progression. Advanced-stage patients displayed significant atrophy of striatum, relative to earlier disease stages.</p></sec><sec id="sec004"><title>Conclusion</title><p>Each pivotal stage in PD appears to be characterized by putative nigrostriatal MRI biomarkers: iron overload at the <italic>de novo</italic> stage, striatal shape changes at early-stage disease and generalized striatal atrophy at advanced disease.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Napolitano, A" uniqKey="Napolitano A">A Napolitano</name></author><author><name sortKey="Manini, P" uniqKey="Manini P">P Manini</name></author><author><name sortKey="D Ischia, M" uniqKey="D Ischia M">M d'Ischia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dexter, Dt" uniqKey="Dexter D">DT Dexter</name></author><author><name sortKey="Wells, Fr" uniqKey="Wells F">FR Wells</name></author><author><name sortKey="Agid, F" uniqKey="Agid F">F Agid</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffiths, Pd" uniqKey="Griffiths P">PD Griffiths</name></author><author><name sortKey="Crossman, Ar" uniqKey="Crossman A">AR Crossman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallis, Li" uniqKey="Wallis L">LI Wallis</name></author><author><name sortKey="Paley, Mn" uniqKey="Paley M">MN Paley</name></author><author><name sortKey="Graham, Jm" uniqKey="Graham J">JM Graham</name></author><author><name sortKey="Grunewald, Ra" uniqKey="Grunewald R">RA Grünewald</name></author><author><name sortKey="Wignall, El" uniqKey="Wignall E">EL Wignall</name></author><author><name sortKey="Joy, Hm" uniqKey="Joy H">HM Joy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peran, P" uniqKey="Peran P">P Péran</name></author><author><name sortKey="Cherubini, A" uniqKey="Cherubini A">A Cherubini</name></author><author><name sortKey="Assogna, F" uniqKey="Assogna F">F Assogna</name></author><author><name sortKey="Piras, F" uniqKey="Piras F">F Piras</name></author><author><name sortKey="Quattrocchi, C" uniqKey="Quattrocchi C">C Quattrocchi</name></author><author><name sortKey="Peppe, A" uniqKey="Peppe A">A Peppe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bunzeck, N" uniqKey="Bunzeck N">N Bunzeck</name></author><author><name sortKey="Singh Curry, V" uniqKey="Singh Curry V">V Singh-Curry</name></author><author><name sortKey="Eckart, C" uniqKey="Eckart C">C Eckart</name></author><author><name sortKey="Weiskopf, N" uniqKey="Weiskopf N">N Weiskopf</name></author><author><name sortKey="Perry, Rj" uniqKey="Perry R">RJ Perry</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, G" uniqKey="Du G">G Du</name></author><author><name sortKey="Lewis, Mm" uniqKey="Lewis M">MM Lewis</name></author><author><name sortKey="Styner, M" uniqKey="Styner M">M Styner</name></author><author><name sortKey="Shaffer, Ml" uniqKey="Shaffer M">ML Shaffer</name></author><author><name sortKey="Sen, S" uniqKey="Sen S">S Sen</name></author><author><name sortKey="Yang, Qx" uniqKey="Yang Q">QX Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Wrw" uniqKey="Martin W">WRW Martin</name></author><author><name sortKey="Wieler, M" uniqKey="Wieler M">M Wieler</name></author><author><name sortKey="Gee, M" uniqKey="Gee M">M Gee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ulla, M" uniqKey="Ulla M">M Ulla</name></author><author><name sortKey="Bonny, Jm" uniqKey="Bonny J">JM Bonny</name></author><author><name sortKey="Ouchchane, L" uniqKey="Ouchchane L">L Ouchchane</name></author><author><name sortKey="Rieu, I" uniqKey="Rieu I">I Rieu</name></author><author><name sortKey="Claise, B" uniqKey="Claise B">B Claise</name></author><author><name sortKey="Durif, F" uniqKey="Durif F">F Durif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Moreau, C" uniqKey="Moreau C">C Moreau</name></author><author><name sortKey="Devedjian, Jc" uniqKey="Devedjian J">JC Devedjian</name></author><author><name sortKey="Kluza, J" uniqKey="Kluza J">J Kluza</name></author><author><name sortKey="Petrault, M" uniqKey="Petrault M">M Petrault</name></author><author><name sortKey="Laloux, C" uniqKey="Laloux C">C Laloux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aquino, D" uniqKey="Aquino D">D Aquino</name></author><author><name sortKey="Contarino, V" uniqKey="Contarino V">V Contarino</name></author><author><name sortKey="Albanese, A" uniqKey="Albanese A">A Albanese</name></author><author><name sortKey="Minati, L" uniqKey="Minati L">L Minati</name></author><author><name sortKey="Farina, L" uniqKey="Farina L">L Farina</name></author><author><name sortKey="Grisoli, M" uniqKey="Grisoli M">M Grisoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geng, Dy" uniqKey="Geng D">DY Geng</name></author><author><name sortKey="Li, Yx" uniqKey="Li Y">YX Li</name></author><author><name sortKey="Zee, Cs" uniqKey="Zee C">CS Zee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pitcher, Tl" uniqKey="Pitcher T">TL Pitcher</name></author><author><name sortKey="Melzer, Tr" uniqKey="Melzer T">TR Melzer</name></author><author><name sortKey="Macaskill, Mr" uniqKey="Macaskill M">MR Macaskill</name></author><author><name sortKey="Graham, Cf" uniqKey="Graham C">CF Graham</name></author><author><name sortKey="Livingston, L" uniqKey="Livingston L">L Livingston</name></author><author><name sortKey="Keenan, Rj" uniqKey="Keenan R">RJ Keenan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apostolova, Lg" uniqKey="Apostolova L">LG Apostolova</name></author><author><name sortKey="Beyer, M" uniqKey="Beyer M">M Beyer</name></author><author><name sortKey="Green, Ae" uniqKey="Green A">AE Green</name></author><author><name sortKey="Hwang, Ks" uniqKey="Hwang K">KS Hwang</name></author><author><name sortKey="Morra, Jh" uniqKey="Morra J">JH Morra</name></author><author><name sortKey="Chou, Yy" uniqKey="Chou Y">YY Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Styner, M" uniqKey="Styner M">M Styner</name></author><author><name sortKey="Oguz, I" uniqKey="Oguz I">I Oguz</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S Xu</name></author><author><name sortKey="Brechbuhler, C" uniqKey="Brechbuhler C">C Brechbühler</name></author><author><name sortKey="Pantazis, D" uniqKey="Pantazis D">D Pantazis</name></author><author><name sortKey="Levitt, Jj" uniqKey="Levitt J">JJ Levitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carriere, N" uniqKey="Carriere N">N Carriere</name></author><author><name sortKey="Besson, P" uniqKey="Besson P">P Besson</name></author><author><name sortKey="Dujardin, K" uniqKey="Dujardin K">K Dujardin</name></author><author><name sortKey="Duhamel, A" uniqKey="Duhamel A">A Duhamel</name></author><author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name></author><author><name sortKey="Delmaire, C" uniqKey="Delmaire C">C Delmaire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sterling, Nw" uniqKey="Sterling N">NW Sterling</name></author><author><name sortKey="Du, G" uniqKey="Du G">G Du</name></author><author><name sortKey="Lewis, Mm" uniqKey="Lewis M">MM Lewis</name></author><author><name sortKey="Dimaio, C" uniqKey="Dimaio C">C Dimaio</name></author><author><name sortKey="Kong, L" uniqKey="Kong L">L Kong</name></author><author><name sortKey="Eslinger, Pj" uniqKey="Eslinger P">PJ Eslinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hm" uniqKey="Lee H">HM Lee</name></author><author><name sortKey="Kwon, Ky" uniqKey="Kwon K">KY Kwon</name></author><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Jang, Jw" uniqKey="Jang J">JW Jang</name></author><author><name sortKey="Suh, Si" uniqKey="Suh S">SI Suh</name></author><author><name sortKey="Koh, Sb" uniqKey="Koh S">SB Koh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniel, Se" uniqKey="Daniel S">SE Daniel</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emre, M" uniqKey="Emre M">M Emre</name></author><author><name sortKey="Aarsland, D" uniqKey="Aarsland D">D Aarsland</name></author><author><name sortKey="Brown, R" uniqKey="Brown R">R Brown</name></author><author><name sortKey="Burn, Dj" uniqKey="Burn D">DJ Burn</name></author><author><name sortKey="Duyckaerts, C" uniqKey="Duyckaerts C">C Duyckaerts</name></author><author><name sortKey="Mizuno, Y" uniqKey="Mizuno Y">Y Mizuno</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Laloux, C" uniqKey="Laloux C">C Laloux</name></author><author><name sortKey="Petrault, M" uniqKey="Petrault M">M Petrault</name></author><author><name sortKey="Lecointe, C" uniqKey="Lecointe C">C Lecointe</name></author><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hallgren, B" uniqKey="Hallgren B">B Hallgren</name></author><author><name sortKey="Sourander, P" uniqKey="Sourander P">P Sourander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siemonsen, S" uniqKey="Siemonsen S">S Siemonsen</name></author><author><name sortKey="Finsterbusch, J" uniqKey="Finsterbusch J">J Finsterbusch</name></author><author><name sortKey="Matschke, J" uniqKey="Matschke J">J Matschke</name></author><author><name sortKey="Lorenzen, A" uniqKey="Lorenzen A">A Lorenzen</name></author><author><name sortKey="Ding, Xq" uniqKey="Ding X">XQ Ding</name></author><author><name sortKey="Fiehler, J" uniqKey="Fiehler J">J Fiehler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, Me" uniqKey="Rossi M">ME Rossi</name></author><author><name sortKey="Ruottinen, H" uniqKey="Ruottinen H">H Ruottinen</name></author><author><name sortKey="Saunam Ki, T" uniqKey="Saunam Ki T">T Saunamäki</name></author><author><name sortKey="Elovaara, I" uniqKey="Elovaara I">I Elovaara</name></author><author><name sortKey="Dastidar, P" uniqKey="Dastidar P">P Dastidar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaur, D" uniqKey="Kaur D">D Kaur</name></author><author><name sortKey="Yantiri, F" uniqKey="Yantiri F">F Yantiri</name></author><author><name sortKey="Rajagopalan, S" uniqKey="Rajagopalan S">S Rajagopalan</name></author><author><name sortKey="Kumar, J" uniqKey="Kumar J">J Kumar</name></author><author><name sortKey="Mo, Jq" uniqKey="Mo J">JQ Mo</name></author><author><name sortKey="Boonplueang, R" uniqKey="Boonplueang R">R Boonplueang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, Lh" uniqKey="You L">LH You</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, Se" uniqKey="Zhao S">SE Zhao</name></author><author><name sortKey="Wang, Sm" uniqKey="Wang S">SM Wang</name></author><author><name sortKey="Zhang, Ll" uniqKey="Zhang L">LL Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haegelen, C" uniqKey="Haegelen C">C Haegelen</name></author><author><name sortKey="Coupe, P" uniqKey="Coupe P">P Coupé</name></author><author><name sortKey="Fonov, V" uniqKey="Fonov V">V Fonov</name></author><author><name sortKey="Guizard, N" uniqKey="Guizard N">N Guizard</name></author><author><name sortKey="Jannin, P" uniqKey="Jannin P">P Jannin</name></author><author><name sortKey="Morandi, X" uniqKey="Morandi X">X Morandi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwon, Dh" uniqKey="Kwon D">DH Kwon</name></author><author><name sortKey="Kim, Jm" uniqKey="Kim J">JM Kim</name></author><author><name sortKey="Oh, Sh" uniqKey="Oh S">SH Oh</name></author><author><name sortKey="Jeong, Hj" uniqKey="Jeong H">HJ Jeong</name></author><author><name sortKey="Park, Sy" uniqKey="Park S">SY Park</name></author><author><name sortKey="Oh, Es" uniqKey="Oh E">ES Oh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minati, L" uniqKey="Minati L">L Minati</name></author><author><name sortKey="Grisoli, M" uniqKey="Grisoli M">M Grisoli</name></author><author><name sortKey="Carella, F" uniqKey="Carella F">F Carella</name></author><author><name sortKey="De Simone, T" uniqKey="De Simone T">T De Simone</name></author><author><name sortKey="Bruzzone, Mg" uniqKey="Bruzzone M">MG Bruzzone</name></author><author><name sortKey="Savoiardo, M" uniqKey="Savoiardo M">M Savoiardo</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000242 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000242 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:4818028
|texte= Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:27035571" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |