Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson's Disease Stages?
Identifieur interne : 000171 ( PubMed/Corpus ); précédent : 000170; suivant : 000172Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson's Disease Stages?
Auteurs : Lucie Hopes ; Guillaume Grolez ; Caroline Moreau ; Renaud Lopes ; Gilles Ryckewaert ; Nicolas Carrière ; Florent Auger ; Charlotte Laloux ; Maud Petrault ; Jean-Christophe Devedjian ; Regis Bordet ; Luc Defebvre ; Patrice Jissendi ; Christine Delmaire ; David DevosSource :
- PloS one [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Acute Disease, Aged, Animals, Biomarkers (analysis), Corpus Striatum (pathology), Cross-Sectional Studies, Female, Humans, Iron (analysis), Iron Overload (complications), Magnetic Resonance Imaging (methods), Male, Mice, Inbred C57BL, Middle Aged, Oxidative Stress, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease, Secondary (complications), Parkinson Disease, Secondary (pathology), Substantia Nigra (pathology).
- MESH :
- chemical , analysis : Biomarkers, Iron.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- complications : Iron Overload, Parkinson Disease, Parkinson Disease, Secondary.
- methods : Magnetic Resonance Imaging.
- pathology : Corpus Striatum, Parkinson Disease, Parkinson Disease, Secondary, Substantia Nigra.
- Acute Disease, Aged, Animals, Cross-Sectional Studies, Female, Humans, Male, Mice, Inbred C57BL, Middle Aged, Oxidative Stress.
Abstract
Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson's disease (PD); R2* values reflect iron content related to high levels of oxidative stress, whereas volume and/or shape changes reflect neuronal death. We sought to assess iron overload in the nigrostriatal system and characterize its relationship with focal and overall atrophy of the striatum in the pivotal stages of PD.
DOI: 10.1371/journal.pone.0147947
PubMed: 27035571
Links to Exploration step
pubmed:27035571Le document en format XML
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<author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name>
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<term>Aged</term>
<term>Animals</term>
<term>Biomarkers (analysis)</term>
<term>Corpus Striatum (pathology)</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Iron (analysis)</term>
<term>Iron Overload (complications)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Middle Aged</term>
<term>Oxidative Stress</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease, Secondary (complications)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Substantia Nigra (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term>
<term>Iron</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Iron Overload</term>
<term>Parkinson Disease</term>
<term>Parkinson Disease, Secondary</term>
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<front><div type="abstract" xml:lang="en">Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson's disease (PD); R2* values reflect iron content related to high levels of oxidative stress, whereas volume and/or shape changes reflect neuronal death. We sought to assess iron overload in the nigrostriatal system and characterize its relationship with focal and overall atrophy of the striatum in the pivotal stages of PD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27035571</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>08</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>04</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>4</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson's Disease Stages?</ArticleTitle>
<Pagination><MedlinePgn>e0147947</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0147947</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson's disease (PD); R2* values reflect iron content related to high levels of oxidative stress, whereas volume and/or shape changes reflect neuronal death. We sought to assess iron overload in the nigrostriatal system and characterize its relationship with focal and overall atrophy of the striatum in the pivotal stages of PD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Twenty controls and 70 PD patients at different disease stages (untreated de novo patients, treated early-stage patients and advanced-stage patients with L-dopa-related motor complications) were included in the study. We determined the R2* values in the substantia nigra, putamen and caudate nucleus, together with striatal volume and shape analysis. We also measured R2* in an acute MPTP mouse model and in a longitudinal follow-up two years later in the early-stage PD patients.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The R2* values in the substantia nigra, putamen and caudate nucleus were significantly higher in de novo PD patients than in controls. Early-stage patients displayed significantly higher R2* values in the substantia nigra (with changes in striatal shape), relative to de novo patients. Measurements after a two-year follow-up in early-stage patients and characterization of the acute MPTP mouse model confirmed that R2* changed rapidly with disease progression. Advanced-stage patients displayed significant atrophy of striatum, relative to earlier disease stages.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Each pivotal stage in PD appears to be characterized by putative nigrostriatal MRI biomarkers: iron overload at the de novo stage, striatal shape changes at early-stage disease and generalized striatal atrophy at advanced disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hopes</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grolez</LastName>
<ForeName>Guillaume</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moreau</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lopes</LastName>
<ForeName>Renaud</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neuroradiology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryckewaert</LastName>
<ForeName>Gilles</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carrière</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Auger</LastName>
<ForeName>Florent</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Small Animal Imaging Unit, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laloux</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Pharmacology, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petrault</LastName>
<ForeName>Maud</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Pharmacology, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Devedjian</LastName>
<ForeName>Jean-Christophe</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Pharmacology, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bordet</LastName>
<ForeName>Regis</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Pharmacology, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Defebvre</LastName>
<ForeName>Luc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jissendi</LastName>
<ForeName>Patrice</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neuroradiology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delmaire</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neuroradiology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Devos</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Movement Disorders and Neurology, Lille University Hospital, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U1171, Faculty of Medicine, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Pharmacology, Lille University, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
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