ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:7574454

Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients

Identifieur interne : 004896 ( Main/Exploration ); précédent : 004895; suivant : 004897

Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients

Auteurs : P. Remy [France] ; Y. Samson [France] ; P. Hantraye [France] ; A. Fontaine [France] ; G. Defer [France] ; J.-F. Mangin [France] ; G. Fenelon [France] ; C. Geny [France] ; F. Ricolfi [France] ; V. Frouin [France] ; J.-P. N'Guyen [France] ; R. Jeny [France] ; J.-D. Degos [France] ; M. Peschanski [France] ; P. Cesaro [France]

Source :

Annals of neurology [ 0364-5134 ] ; 1995.

RBID : Pascal:95-0564874

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Homogreffe, Tissu nerveux, Tomoscintigraphie, Positon, Fonction cellulaire, Greffon, Homme, Chirurgie.
Wicri :
- topic : Homme, Chirurgie.

English descriptors

KwdEn :
- Brain (diagnostic imaging), Brain (pathology), Brain (physiopathology), Cell function, Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (metabolism), Emission tomography, Fetal Tissue Transplantation (diagnostic imaging), Fetal Tissue Transplantation (pathology), Fluorine Radioisotopes, Graft, Graft Survival, Homograft, Human, Humans, Magnetic Resonance Imaging, Middle Aged, Nervous tissue, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (surgery), Parkinson disease, Positron, Surgery, Tomography, Emission-Computed.
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- diagnostic imaging : Brain, Fetal Tissue Transplantation, Parkinson Disease.
- chemical , metabolism : Dihydroxyphenylalanine, Parkinson Disease.
- pathology : Brain, Fetal Tissue Transplantation.
- physiopathology : Brain.
- surgery : Parkinson Disease.
- chemical : Fluorine Radioisotopes, Graft Survival, Humans, Magnetic Resonance Imaging, Middle Aged, Tomography, Emission-Computed.

Abstract

To assess the efficacy of fetal mesencephalic grafts in Parkinson's disease, it is important to know if the grafted cells survive and are functional. Positron emission tomography (PET) and [¹⁸F]fluorodopa ([¹⁸F]dopa) have been used to demonstrate the survival of the grafted cells, but the relationship of [¹⁸F]dopa uptake changes in the grafted striatum to motor function remains unclear. We investigated this question with 16 serial PET scans in 5 severe parkinsonian patients unilaterally grafted in whom we found a significant and progressive increase of the [¹⁸F]dopa uptake in the grafted putamen. The number of patients was too small to assess the sensitivity of [¹⁸F]dopa PET scans in individual patients. Yet, by analyzing the 16 serial PET scans we found a correlation between the [¹⁸F]dopa uptake (K_i) in the grafted putamen and the percentage of daily time spent "on," suggesting that K_i changes have a functional meaning. In addition, the K_i values were correlated with the contralateral finger dexterity to the same extent in both the grafted and nongrafted putamen. These results indicate that [¹⁸F]dopa uptake reflects the motor function of the opposite side of the body, similarly in the grafted and ungrafted putamen, at least in terms of these tasks. Finally, extrapolating from these correlations offers the suggestion that clinical optimal results of the graft could be achieved if the graft brings the K_i values in the putamen to about two standard deviations of mean control values.

Affiliations:

Le document en format XML

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</affiliation>
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<author><name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G." last="Fenelon">G. Fenelon</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>CHU Tenon, serv. neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C." last="Geny">C. Geny</name>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
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<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM Fac. médecine, U 421</s1>
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</author>
<author><name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F." last="Ricolfi">F. Ricolfi</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU Henri Mondor, serv. neuroradiologie</s1>
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<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
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<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM Fac. médecine, U 421</s1>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
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</author>
<author><name sortKey="Frouin, V" sort="Frouin, V" uniqKey="Frouin V" first="V." last="Frouin">V. Frouin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CEA/DSV/DRIPP, serv. hosp. Frédéric Joliot</s1>
<s2>91401 Orsay</s2>
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<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Orsay</settlement>
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<author><name sortKey="N Guyen, J P" sort="N Guyen, J P" uniqKey="N Guyen J" first="J.-P." last="N'Guyen">J.-P. N'Guyen</name>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
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<author><name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R." last="Jeny">R. Jeny</name>
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<wicri:noRegion>St-Maurice</wicri:noRegion>
<wicri:noRegion>serv. gynécologie-obstétrique</wicri:noRegion>
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</affiliation>
</author>
<author><name sortKey="Degos, J D" sort="Degos, J D" uniqKey="Degos J" first="J.-D." last="Degos">J.-D. Degos</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>CHU Henri Mondor, serv. neurologie</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
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<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</placeName>
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</author>
<author><name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M." last="Peschanski">M. Peschanski</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM Fac. médecine, U 421</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</affiliation>
</author>
<author><name sortKey="Cesaro, P" sort="Cesaro, P" uniqKey="Cesaro P" first="P." last="Cesaro">P. Cesaro</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>CHU Henri Mondor, serv. neurologie</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM Fac. médecine, U 421</s1>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="1995">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (diagnostic imaging)</term>
<term>Brain (pathology)</term>
<term>Brain (physiopathology)</term>
<term>Cell function</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Dihydroxyphenylalanine (metabolism)</term>
<term>Emission tomography</term>
<term>Fetal Tissue Transplantation (diagnostic imaging)</term>
<term>Fetal Tissue Transplantation (pathology)</term>
<term>Fluorine Radioisotopes</term>
<term>Graft</term>
<term>Graft Survival</term>
<term>Homograft</term>
<term>Human</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Middle Aged</term>
<term>Nervous tissue</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Surgery</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term>
<term>Fetal Tissue Transplantation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Fetal Tissue Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorine Radioisotopes</term>
<term>Graft Survival</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Middle Aged</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Homogreffe</term>
<term>Tissu nerveux</term>
<term>Tomoscintigraphie</term>
<term>Positon</term>
<term>Fonction cellulaire</term>
<term>Greffon</term>
<term>Homme</term>
<term>Chirurgie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Chirurgie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To assess the efficacy of fetal mesencephalic grafts in Parkinson's disease, it is important to know if the grafted cells survive and are functional. Positron emission tomography (PET) and [<sup>18</sup>
F]fluorodopa ([<sup>18</sup>
F]dopa) have been used to demonstrate the survival of the grafted cells, but the relationship of [<sup>18</sup>
F]dopa uptake changes in the grafted striatum to motor function remains unclear. We investigated this question with 16 serial PET scans in 5 severe parkinsonian patients unilaterally grafted in whom we found a significant and progressive increase of the [<sup>18</sup>
F]dopa uptake in the grafted putamen. The number of patients was too small to assess the sensitivity of [<sup>18</sup>
F]dopa PET scans in individual patients. Yet, by analyzing the 16 serial PET scans we found a correlation between the [<sup>18</sup>
F]dopa uptake (K<sub>i</sub>
) in the grafted putamen and the percentage of daily time spent "on," suggesting that K<sub>i</sub>
 changes have a functional meaning. In addition, the K<sub>i</sub>
 values were correlated with the contralateral finger dexterity to the same extent in both the grafted and nongrafted putamen. These results indicate that [<sup>18</sup>
F]dopa uptake reflects the motor function of the opposite side of the body, similarly in the grafted and ungrafted putamen, at least in terms of these tasks. Finally, extrapolating from these correlations offers the suggestion that clinical optimal results of the graft could be achieved if the graft brings the K<sub>i</sub>
 values in the putamen to about two standard deviations of mean control values.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Créteil</li>
<li>Orsay</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P." last="Remy">P. Remy</name>
</region>
<name sortKey="Cesaro, P" sort="Cesaro, P" uniqKey="Cesaro P" first="P." last="Cesaro">P. Cesaro</name>
<name sortKey="Cesaro, P" sort="Cesaro, P" uniqKey="Cesaro P" first="P." last="Cesaro">P. Cesaro</name>
<name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G." last="Defer">G. Defer</name>
<name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G." last="Defer">G. Defer</name>
<name sortKey="Degos, J D" sort="Degos, J D" uniqKey="Degos J" first="J.-D." last="Degos">J.-D. Degos</name>
<name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G." last="Fenelon">G. Fenelon</name>
<name sortKey="Fontaine, A" sort="Fontaine, A" uniqKey="Fontaine A" first="A." last="Fontaine">A. Fontaine</name>
<name sortKey="Frouin, V" sort="Frouin, V" uniqKey="Frouin V" first="V." last="Frouin">V. Frouin</name>
<name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C." last="Geny">C. Geny</name>
<name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C." last="Geny">C. Geny</name>
<name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P." last="Hantraye">P. Hantraye</name>
<name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P." last="Hantraye">P. Hantraye</name>
<name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R." last="Jeny">R. Jeny</name>
<name sortKey="Mangin, J F" sort="Mangin, J F" uniqKey="Mangin J" first="J.-F." last="Mangin">J.-F. Mangin</name>
<name sortKey="N Guyen, J P" sort="N Guyen, J P" uniqKey="N Guyen J" first="J.-P." last="N'Guyen">J.-P. N'Guyen</name>
<name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M." last="Peschanski">M. Peschanski</name>
<name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F." last="Ricolfi">F. Ricolfi</name>
<name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F." last="Ricolfi">F. Ricolfi</name>
<name sortKey="Samson, Y" sort="Samson, Y" uniqKey="Samson Y" first="Y." last="Samson">Y. Samson</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients

Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients

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	La maladie de Parkinson en France (serveur d'exploration)
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