Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.
Identifieur interne : 001615 ( PubMed/Corpus ); précédent : 001614; suivant : 001616Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.
Auteurs : P. Remy ; Y. Samson ; P. Hantraye ; A. Fontaine ; G. Defer ; J F Mangin ; G. Fénelon ; C. Gény ; F. Ricolfi ; V. FrouinSource :
- Annals of neurology [ 0364-5134 ] ; 1995.
English descriptors
- KwdEn :
- Brain (diagnostic imaging), Brain (pathology), Brain (physiopathology), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (metabolism), Fetal Tissue Transplantation (diagnostic imaging), Fetal Tissue Transplantation (pathology), Fluorine Radioisotopes, Graft Survival, Humans, Magnetic Resonance Imaging, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (surgery), Tomography, Emission-Computed.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- diagnostic imaging : Brain, Fetal Tissue Transplantation, Parkinson Disease.
- chemical , metabolism : Dihydroxyphenylalanine, Parkinson Disease.
- pathology : Brain, Fetal Tissue Transplantation.
- physiopathology : Brain.
- surgery : Parkinson Disease.
- chemical : Fluorine Radioisotopes, Graft Survival, Humans, Magnetic Resonance Imaging, Middle Aged, Tomography, Emission-Computed.
Abstract
To assess the efficacy of fetal mesencephalic grafts in Parkinson's disease, it is important to know if the grafted cells survive and are functional. Positron emission tomography (PET) and [18F]fluorodopa ([18F]dopa) have been used to demonstrate the survival of the grafted cells, but the relationship of [18F]dopa uptake changes in the grafted striatum to motor function remains unclear. We investigated this question with 16 serial PET scans in 5 severe parkinsonian patients unilaterally grafted in whom we found a significant and progressive increase of the [18F]dopa uptake in the grafted putamen. The number of patients was too small to assess the sensitivity of [18F]dopa PET scans in individual patients. Yet, by analyzing the 16 serial PET scans we found a correlation between the [18F]dopa uptake (Ki) in the grafted putamen and the percentage of daily time spent "on," suggesting that Ki changes have a functional meaning. In addition, the Ki values were correlated with the contralateral finger dexterity to the same extent in both the grafted and nongrafted putamen. These results indicate that [18F]dopa uptake reflects the motor function of the opposite side of the body, similarly in the grafted and ungrafted putamen, at least in terms of these tasks. Finally, extrapolating from these correlations offers the suggestion that clinical optimal results of the graft could be achieved if the graft brings the Ki values in the putamen to about two standard deviations of mean control values.
DOI: 10.1002/ana.410380406
PubMed: 7574454
Links to Exploration step
pubmed:7574454Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.</title><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name><affiliation><nlm:affiliation>Service Hospitalier Frédéric Joliot, CEA/DSV/DRIPP, Orsay, France.</nlm:affiliation></affiliation></author><author><name sortKey="Samson, Y" sort="Samson, Y" uniqKey="Samson Y" first="Y" last="Samson">Y. Samson</name></author><author><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P" last="Hantraye">P. Hantraye</name></author><author><name sortKey="Fontaine, A" sort="Fontaine, A" uniqKey="Fontaine A" first="A" last="Fontaine">A. Fontaine</name></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name></author><author><name sortKey="Mangin, J F" sort="Mangin, J F" uniqKey="Mangin J" first="J F" last="Mangin">J F Mangin</name></author><author><name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G" last="Fénelon">G. Fénelon</name></author><author><name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C" last="Gény">C. Gény</name></author><author><name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F" last="Ricolfi">F. Ricolfi</name></author><author><name sortKey="Frouin, V" sort="Frouin, V" uniqKey="Frouin V" first="V" last="Frouin">V. Frouin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7574454</idno><idno type="pmid">7574454</idno><idno type="doi">10.1002/ana.410380406</idno><idno type="wicri:Area/PubMed/Corpus">001615</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001615</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.</title><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name><affiliation><nlm:affiliation>Service Hospitalier Frédéric Joliot, CEA/DSV/DRIPP, Orsay, France.</nlm:affiliation></affiliation></author><author><name sortKey="Samson, Y" sort="Samson, Y" uniqKey="Samson Y" first="Y" last="Samson">Y. Samson</name></author><author><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P" last="Hantraye">P. Hantraye</name></author><author><name sortKey="Fontaine, A" sort="Fontaine, A" uniqKey="Fontaine A" first="A" last="Fontaine">A. Fontaine</name></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name></author><author><name sortKey="Mangin, J F" sort="Mangin, J F" uniqKey="Mangin J" first="J F" last="Mangin">J F Mangin</name></author><author><name sortKey="Fenelon, G" sort="Fenelon, G" uniqKey="Fenelon G" first="G" last="Fénelon">G. Fénelon</name></author><author><name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C" last="Gény">C. Gény</name></author><author><name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F" last="Ricolfi">F. Ricolfi</name></author><author><name sortKey="Frouin, V" sort="Frouin, V" uniqKey="Frouin V" first="V" last="Frouin">V. Frouin</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (diagnostic imaging)</term><term>Brain (pathology)</term><term>Brain (physiopathology)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (metabolism)</term><term>Fetal Tissue Transplantation (diagnostic imaging)</term><term>Fetal Tissue Transplantation (pathology)</term><term>Fluorine Radioisotopes</term><term>Graft Survival</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (surgery)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Fetal Tissue Transplantation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Graft Survival</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the efficacy of fetal mesencephalic grafts in Parkinson's disease, it is important to know if the grafted cells survive and are functional. Positron emission tomography (PET) and [18F]fluorodopa ([18F]dopa) have been used to demonstrate the survival of the grafted cells, but the relationship of [18F]dopa uptake changes in the grafted striatum to motor function remains unclear. We investigated this question with 16 serial PET scans in 5 severe parkinsonian patients unilaterally grafted in whom we found a significant and progressive increase of the [18F]dopa uptake in the grafted putamen. The number of patients was too small to assess the sensitivity of [18F]dopa PET scans in individual patients. Yet, by analyzing the 16 serial PET scans we found a correlation between the [18F]dopa uptake (Ki) in the grafted putamen and the percentage of daily time spent "on," suggesting that Ki changes have a functional meaning. In addition, the Ki values were correlated with the contralateral finger dexterity to the same extent in both the grafted and nongrafted putamen. These results indicate that [18F]dopa uptake reflects the motor function of the opposite side of the body, similarly in the grafted and ungrafted putamen, at least in terms of these tasks. Finally, extrapolating from these correlations offers the suggestion that clinical optimal results of the graft could be achieved if the graft brings the Ki values in the putamen to about two standard deviations of mean control values.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7574454</PMID><DateCreated><Year>1995</Year><Month>11</Month><Day>09</Day></DateCreated><DateCompleted><Year>1995</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0364-5134</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>4</Issue><PubDate><Year>1995</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Annals of neurology</Title><ISOAbbreviation>Ann. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.</ArticleTitle><Pagination><MedlinePgn>580-8</MedlinePgn></Pagination><Abstract><AbstractText>To assess the efficacy of fetal mesencephalic grafts in Parkinson's disease, it is important to know if the grafted cells survive and are functional. Positron emission tomography (PET) and [18F]fluorodopa ([18F]dopa) have been used to demonstrate the survival of the grafted cells, but the relationship of [18F]dopa uptake changes in the grafted striatum to motor function remains unclear. We investigated this question with 16 serial PET scans in 5 severe parkinsonian patients unilaterally grafted in whom we found a significant and progressive increase of the [18F]dopa uptake in the grafted putamen. The number of patients was too small to assess the sensitivity of [18F]dopa PET scans in individual patients. Yet, by analyzing the 16 serial PET scans we found a correlation between the [18F]dopa uptake (Ki) in the grafted putamen and the percentage of daily time spent "on," suggesting that Ki changes have a functional meaning. In addition, the Ki values were correlated with the contralateral finger dexterity to the same extent in both the grafted and nongrafted putamen. These results indicate that [18F]dopa uptake reflects the motor function of the opposite side of the body, similarly in the grafted and ungrafted putamen, at least in terms of these tasks. Finally, extrapolating from these correlations offers the suggestion that clinical optimal results of the graft could be achieved if the graft brings the Ki values in the putamen to about two standard deviations of mean control values.</AbstractText></Abstract><AuthorList CompleteYN="N"><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service Hospitalier Frédéric Joliot, CEA/DSV/DRIPP, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samson</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hantraye</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Fontaine</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Defer</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Mangin</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Fénelon</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Gény</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ricolfi</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Frouin</LastName><ForeName>V</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Neurol</MedlineTA><NlmUniqueID>7707449</NlmUniqueID><ISSNLinking>0364-5134</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005462">Fluorine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>2C598205QX</RegistryNumber><NameOfSubstance UI="C043437">fluorodopa F 18</NameOfSubstance></Chemical><Chemical><RegistryNumber>63-84-3</RegistryNumber><NameOfSubstance UI="D004295">Dihydroxyphenylalanine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004295" MajorTopicYN="N">Dihydroxyphenylalanine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016332" MajorTopicYN="N">Fetal Tissue Transplantation</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005462" MajorTopicYN="Y">Fluorine Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006085" MajorTopicYN="N">Graft Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7574454</ArticleId><ArticleId IdType="doi">10.1002/ana.410380406</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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