ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:27214664

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

Identifieur interne : 000377 ( Main/Exploration ); précédent : 000376; suivant : 000378

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

Auteurs : François Tison [France] ; Charlotte Keywood [Suisse] ; Mark Wakefield [Suisse] ; Franck Durif [France] ; Jean-Christophe Corvol [France] ; Karla Eggert [Allemagne] ; Mark Lew [États-Unis] ; Stuart Isaacson [États-Unis] ; Erwan Bezard [France] ; Sonia-Maria Poli [Suisse] ; Christopher G. Goetz [États-Unis] ; Claudia Trenkwalder [Allemagne] ; Olivier Rascol [France]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.

RBID : pubmed:27214664

Abstract

The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).

DOI: 10.1002/mds.26659
PubMed: 27214664

Affiliations:

Le document en format XML

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<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
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<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
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<placeName><region type="state">Floride</region>
</placeName>
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<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.</title>
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<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
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<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
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<author><name sortKey="Lew, Mark" sort="Lew, Mark" uniqKey="Lew M" first="Mark" last="Lew">Mark Lew</name>
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</placeName>
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<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="2"><nlm:affiliation>Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation wicri:level="4"><nlm:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux</wicri:regionArea>
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</author>
<author><name sortKey="Poli, Sonia Maria" sort="Poli, Sonia Maria" uniqKey="Poli S" first="Sonia-Maria" last="Poli">Sonia-Maria Poli</name>
<affiliation wicri:level="1"><nlm:affiliation>Addex Pharma SA, Plan Les Ouates, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Addex Pharma SA, Plan Les Ouates</wicri:regionArea>
<wicri:noRegion>Plan Les Ouates</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name>
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<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<affiliation wicri:level="3"><nlm:affiliation>NS-Park/FCRIN Network, UMS 015, Toulouse, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<front><div type="abstract" xml:lang="en">The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<li>Suisse</li>
<li>États-Unis</li>
</country>
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<li>Californie</li>
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<tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name>
</region>
<name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name>
<name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
<name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Keywood, Charlotte" sort="Keywood, Charlotte" uniqKey="Keywood C" first="Charlotte" last="Keywood">Charlotte Keywood</name>
</noRegion>
<name sortKey="Poli, Sonia Maria" sort="Poli, Sonia Maria" uniqKey="Poli S" first="Sonia-Maria" last="Poli">Sonia-Maria Poli</name>
<name sortKey="Wakefield, Mark" sort="Wakefield, Mark" uniqKey="Wakefield M" first="Mark" last="Wakefield">Mark Wakefield</name>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
</region>
<name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Lew, Mark" sort="Lew, Mark" uniqKey="Lew M" first="Mark" last="Lew">Mark Lew</name>
</region>
<name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name>
<name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
</country>
</tree>
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</record>

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La maladie de Parkinson en France (serveur d'exploration)

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

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	La maladie de Parkinson en France (serveur d'exploration)
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