A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Identifieur interne : 000377 ( Main/Exploration ); précédent : 000376; suivant : 000378A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Auteurs : François Tison [France] ; Charlotte Keywood [Suisse] ; Mark Wakefield [Suisse] ; Franck Durif [France] ; Jean-Christophe Corvol [France] ; Karla Eggert [Allemagne] ; Mark Lew [États-Unis] ; Stuart Isaacson [États-Unis] ; Erwan Bezard [France] ; Sonia-Maria Poli [Suisse] ; Christopher G. Goetz [États-Unis] ; Claudia Trenkwalder [Allemagne] ; Olivier Rascol [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).
DOI: 10.1002/mds.26659
PubMed: 27214664
Affiliations:
- Allemagne, France, Suisse, États-Unis
- Aquitaine, Californie, District de Giessen, District de Kassel, Floride, Hesse (Land), Illinois, Midi-Pyrénées, Nouvelle-Aquitaine, Occitanie (région administrative)
- Bordeaux, Cassel (Hesse), Marbourg, Toulouse
- Université de Bordeaux
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).</div>
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