A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Identifieur interne : 000379 ( Main/Merge ); précédent : 000378; suivant : 000380A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Auteurs : François Tison [France] ; Charlotte Keywood [Suisse] ; Mark Wakefield [Suisse] ; Franck Durif [France] ; Jean-Christophe Corvol [France] ; Karla Eggert [Allemagne] ; Mark Lew [États-Unis] ; Stuart Isaacson [États-Unis] ; Erwan Bezard [France] ; Sonia-Maria Poli [Suisse] ; Christopher G. Goetz [États-Unis] ; Claudia Trenkwalder [Allemagne] ; Olivier Rascol [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).
DOI: 10.1002/mds.26659
PubMed: 27214664
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pubmed:27214664Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.</title>
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<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
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<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
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<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Poli, Sonia Maria" sort="Poli, Sonia Maria" uniqKey="Poli S" first="Sonia-Maria" last="Poli">Sonia-Maria Poli</name>
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<author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name>
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<author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
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<front><div type="abstract" xml:lang="en">The metabotropic glutamate receptor 5-negative allosteric modulator dipraglurant reduces levodopa-induced dyskinesia in the MPTP-macaque model. The objective of this study was to assess the safety, tolerability (primary objective), and efficacy (secondary objective) of dipraglurant on levodopa-induced dyskinesia in Parkinson's disease (PD).</div>
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