Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Identifieur interne : 000556 ( Main/Exploration ); précédent : 000555; suivant : 000557Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Auteurs : Sonia Lavisse [France] ; Daniel García-Lorenzo [France] ; Marie-Anne Peyronneau [France] ; Benedetta Bodini [Royaume-Uni] ; Claire Thiriez [France] ; Bertrand Kuhnast [France] ; Claude Comtat [France] ; Philippe Remy ; Bruno Stankoff [France] ; Michel Bottlaender [France]Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 1535-5667 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Brain (diagnostic imaging), Cerebellum (diagnostic imaging), Female, Fluorine Radioisotopes (chemistry), Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Inflammation (pathology), Ligands, Male, Middle Aged, Neurodegenerative Diseases (diagnostic imaging), Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding, Pyrazoles (chemistry), Pyrimidines (chemistry), Receptors, GABA (metabolism), Thalamus (diagnostic imaging).
- MESH :
- chemical , chemistry : Fluorine Radioisotopes, Pyrazoles, Pyrimidines.
- diagnostic imaging : Brain, Cerebellum, Neurodegenerative Diseases, Thalamus.
- chemical , metabolism : Receptors, GABA.
- pathology : Inflammation.
- Adult, Female, Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Ligands, Male, Middle Aged, Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding.
Abstract
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.
DOI: 10.2967/jnumed.115.156083
PubMed: 26025960
Affiliations:
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Le document en format XML
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France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old 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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" 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type="wicri:Area/Main/Curation">000556</idno><idno type="wicri:Area/Main/Exploration">000556</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.</title><author><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France sonia.lavisse@cea.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Lorenzo, Daniel" sort="Garcia Lorenzo, Daniel" uniqKey="Garcia Lorenzo D" first="Daniel" last="García-Lorenzo">Daniel García-Lorenzo</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Peyronneau, Marie Anne" sort="Peyronneau, Marie Anne" uniqKey="Peyronneau M" first="Marie-Anne" last="Peyronneau">Marie-Anne Peyronneau</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Bodini, Benedetta" sort="Bodini, Benedetta" uniqKey="Bodini B" first="Benedetta" last="Bodini">Benedetta Bodini</name><affiliation wicri:level="2"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Kuhnast, Bertrand" sort="Kuhnast, Bertrand" uniqKey="Kuhnast B" first="Bertrand" last="Kuhnast">Bertrand Kuhnast</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Comtat, Claude" sort="Comtat, Claude" uniqKey="Comtat C" first="Claude" last="Comtat">Claude Comtat</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Stankoff, Bruno" sort="Stankoff, Bruno" uniqKey="Stankoff B" first="Bruno" last="Stankoff">Bruno Stankoff</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><affiliation wicri:level="3"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="eISSN">1535-5667</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain (diagnostic imaging)</term><term>Cerebellum (diagnostic imaging)</term><term>Female</term><term>Fluorine Radioisotopes (chemistry)</term><term>Genotype</term><term>Healthy Volunteers</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Inflammation (pathology)</term><term>Ligands</term><term>Male</term><term>Middle Aged</term><term>Neurodegenerative Diseases (diagnostic imaging)</term><term>Polymorphism, Genetic</term><term>Positron-Emission Tomography</term><term>Protein Binding</term><term>Pyrazoles (chemistry)</term><term>Pyrimidines (chemistry)</term><term>Receptors, GABA (metabolism)</term><term>Thalamus (diagnostic imaging)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Pyrazoles</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Cerebellum</term><term>Neurodegenerative Diseases</term><term>Thalamus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, GABA</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Genotype</term><term>Healthy Volunteers</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Ligands</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Positron-Emission Tomography</term><term>Protein Binding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Gif-sur-Yvette</li><li>Orsay</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></noCountry><country name="France"><noRegion><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name></noRegion><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><name sortKey="Comtat, Claude" sort="Comtat, Claude" uniqKey="Comtat C" first="Claude" last="Comtat">Claude Comtat</name><name sortKey="Garcia Lorenzo, Daniel" sort="Garcia Lorenzo, Daniel" uniqKey="Garcia Lorenzo D" first="Daniel" last="García-Lorenzo">Daniel García-Lorenzo</name><name sortKey="Kuhnast, Bertrand" sort="Kuhnast, Bertrand" uniqKey="Kuhnast B" first="Bertrand" last="Kuhnast">Bertrand Kuhnast</name><name sortKey="Peyronneau, Marie Anne" sort="Peyronneau, Marie Anne" uniqKey="Peyronneau M" first="Marie-Anne" last="Peyronneau">Marie-Anne Peyronneau</name><name sortKey="Stankoff, Bruno" sort="Stankoff, Bruno" uniqKey="Stankoff B" first="Bruno" last="Stankoff">Bruno Stankoff</name><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bodini, Benedetta" sort="Bodini, Benedetta" uniqKey="Bodini B" first="Benedetta" last="Bodini">Benedetta Bodini</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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