Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Identifieur interne : 001726 ( Ncbi/Curation ); précédent : 001725; suivant : 001727Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Auteurs : Sonia Lavisse [France] ; Daniel García-Lorenzo [France] ; Marie-Anne Peyronneau [France] ; Benedetta Bodini [Royaume-Uni] ; Claire Thiriez [France] ; Bertrand Kuhnast [France] ; Claude Comtat [France] ; Philippe Remy ; Bruno Stankoff [France] ; Michel Bottlaender [France]Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 1535-5667 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Brain (diagnostic imaging), Cerebellum (diagnostic imaging), Female, Fluorine Radioisotopes (chemistry), Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Inflammation (pathology), Ligands, Male, Middle Aged, Neurodegenerative Diseases (diagnostic imaging), Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding, Pyrazoles (chemistry), Pyrimidines (chemistry), Receptors, GABA (metabolism), Thalamus (diagnostic imaging).
- MESH :
- chemical , chemistry : Fluorine Radioisotopes, Pyrazoles, Pyrimidines.
- diagnostic imaging : Brain, Cerebellum, Neurodegenerative Diseases, Thalamus.
- chemical , metabolism : Receptors, GABA.
- pathology : Inflammation.
- Adult, Female, Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Ligands, Male, Middle Aged, Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding.
Abstract
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.
DOI: 10.2967/jnumed.115.156083
PubMed: 26025960
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Philippe Remy<affiliation><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>
Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Brain (diagnostic imaging)</term>
<term>Cerebellum (diagnostic imaging)</term>
<term>Female</term>
<term>Fluorine Radioisotopes (chemistry)</term>
<term>Genotype</term>
<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Inflammation (pathology)</term>
<term>Ligands</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurodegenerative Diseases (diagnostic imaging)</term>
<term>Polymorphism, Genetic</term>
<term>Positron-Emission Tomography</term>
<term>Protein Binding</term>
<term>Pyrazoles (chemistry)</term>
<term>Pyrimidines (chemistry)</term>
<term>Receptors, GABA (metabolism)</term>
<term>Thalamus (diagnostic imaging)</term>
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<term>Pyrimidines</term>
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<term>Cerebellum</term>
<term>Neurodegenerative Diseases</term>
<term>Thalamus</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
</keywords>
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<term>Female</term>
<term>Genotype</term>
<term>Healthy Volunteers</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Ligands</term>
<term>Male</term>
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<term>Polymorphism, Genetic</term>
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<front><div type="abstract" xml:lang="en">Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.</div>
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