Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.
Identifieur interne : 001584 ( Main/Exploration ); précédent : 001583; suivant : 001585Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease.
Auteurs : Lei Wang [République populaire de Chine] ; Ji-Feng Guo ; Wen-Wen Zhang ; Qian Xu ; Xing Zuo ; Chang-He Shi ; Lin-Zi Luo ; Jia Liu ; Liang Hu ; Ya-Cen Hu ; Xin-Xiang Yan ; Bei-Sha TangSource :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [ 1532-2653 ] ; 2011.
Descripteurs français
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Asian Continental Ancestry Group (genetics), Carrier Proteins (genetics), Case-Control Studies, China, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Single Nucleotide.
- MESH :
- chemical , genetics : Carrier Proteins.
- geographic : China.
- genetics : Asian Continental Ancestry Group, Parkinson Disease.
- Aged, Aged, 80 and over, Case-Control Studies, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.
DOI: 10.1016/j.jocn.2011.05.014
PubMed: 22115759
Affiliations:
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that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France. However, no comprehensive study of the GIGYF2 gene has been conducted among PD patients from mainland China. In our previous study, the GIGYF2 gene was directly sequenced, and nine missense variants and 14 polymorphisms were identified. For these 14 polymorphisms, in the present study we performed a case–control analysis for 300 PD patients and 200 healthy controls from mainland China. The c.297T>C p.Ala99Ala polymorphism was associated with increased risk with respect to the pathogenesis of sporadic PD. In conclusion, within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing PD.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Guo, Ji Feng" sort="Guo, Ji Feng" uniqKey="Guo J" first="Ji-Feng" last="Guo">Ji-Feng Guo</name><name sortKey="Hu, Liang" sort="Hu, Liang" uniqKey="Hu L" first="Liang" last="Hu">Liang Hu</name><name sortKey="Hu, Ya Cen" sort="Hu, Ya Cen" uniqKey="Hu Y" first="Ya-Cen" last="Hu">Ya-Cen Hu</name><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><name sortKey="Luo, Lin Zi" sort="Luo, Lin Zi" uniqKey="Luo L" first="Lin-Zi" last="Luo">Lin-Zi Luo</name><name sortKey="Shi, Chang He" sort="Shi, Chang He" uniqKey="Shi C" first="Chang-He" last="Shi">Chang-He Shi</name><name sortKey="Tang, Bei Sha" sort="Tang, Bei Sha" uniqKey="Tang B" first="Bei-Sha" last="Tang">Bei-Sha Tang</name><name sortKey="Xu, Qian" sort="Xu, Qian" uniqKey="Xu Q" first="Qian" last="Xu">Qian Xu</name><name sortKey="Yan, Xin Xiang" sort="Yan, Xin Xiang" uniqKey="Yan X" first="Xin-Xiang" last="Yan">Xin-Xiang Yan</name><name sortKey="Zhang, Wen Wen" sort="Zhang, Wen Wen" uniqKey="Zhang W" first="Wen-Wen" last="Zhang">Wen-Wen Zhang</name><name sortKey="Zuo, Xing" sort="Zuo, Xing" uniqKey="Zuo X" first="Xing" last="Zuo">Xing Zuo</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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