New animal models of Parkinson's disease.
Identifieur interne : 001550 ( Main/Exploration ); précédent : 001549; suivant : 001551New animal models of Parkinson's disease.
Auteurs : Benjamin Dehay [France] ; Erwan BezardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
Abstract
Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in the affected brain regions, of protein inclusions named Lewy Bodies. Despite the fact that numerous mutations causing hereditary forms of Parkinson's disease have been identified in the last decade, current transgenic animal models do not adequately reproduce cardinal features of the human disease. Altogether, the animal models derived of human mutations indicate that the nigrostriatal degenerative process results from the combination of several mechanisms that implicate mitochondrial dysfunction, oxidative damage, and protein degradation impairment.
PubMed: 22046592
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000968
- to stream PubMed, to step Curation: 000928
- to stream PubMed, to step Checkpoint: 000928
- to stream Ncbi, to step Merge: 000E03
- to stream Ncbi, to step Curation: 000E03
- to stream Ncbi, to step Checkpoint: 000E03
- to stream Main, to step Merge: 001628
- to stream Main, to step Curation: 001550
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New animal models of Parkinson's disease.</title>
<author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux, France. benjamin.dehay@u-bordeaux2.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:22046592</idno>
<idno type="pmid">22046592</idno>
<idno type="wicri:Area/PubMed/Corpus">000968</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000968</idno>
<idno type="wicri:Area/PubMed/Curation">000928</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000928</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000928</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000928</idno>
<idno type="wicri:Area/Ncbi/Merge">000E03</idno>
<idno type="wicri:Area/Ncbi/Curation">000E03</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E03</idno>
<idno type="wicri:Area/Main/Merge">001628</idno>
<idno type="wicri:Area/Main/Curation">001550</idno>
<idno type="wicri:Area/Main/Exploration">001550</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">New animal models of Parkinson's disease.</title>
<author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name>
<affiliation wicri:level="3"><nlm:affiliation>Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux, France. benjamin.dehay@u-bordeaux2.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Caenorhabditis elegans</term>
<term>Disease Models, Animal</term>
<term>Drosophila melanogaster</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Parkinson Disease (genetics)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Caenorhabditis elegans</term>
<term>Disease Models, Animal</term>
<term>Drosophila melanogaster</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in the affected brain regions, of protein inclusions named Lewy Bodies. Despite the fact that numerous mutations causing hereditary forms of Parkinson's disease have been identified in the last decade, current transgenic animal models do not adequately reproduce cardinal features of the human disease. Altogether, the animal models derived of human mutations indicate that the nigrostriatal degenerative process results from the combination of several mechanisms that implicate mitochondrial dysfunction, oxidative damage, and protein degradation impairment.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
</region>
<settlement><li>Bordeaux</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</noCountry>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001550 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001550 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:22046592 |texte= New animal models of Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22046592" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |