New animal models of Parkinson's disease.
Identifieur interne : 001550 ( Main/Curation ); précédent : 001549; suivant : 001551New animal models of Parkinson's disease.
Auteurs : Benjamin Dehay [France] ; Erwan BezardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
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- MESH :
Abstract
Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in the affected brain regions, of protein inclusions named Lewy Bodies. Despite the fact that numerous mutations causing hereditary forms of Parkinson's disease have been identified in the last decade, current transgenic animal models do not adequately reproduce cardinal features of the human disease. Altogether, the animal models derived of human mutations indicate that the nigrostriatal degenerative process results from the combination of several mechanisms that implicate mitochondrial dysfunction, oxidative damage, and protein degradation impairment.
PubMed: 22046592
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pubmed:22046592Le document en format XML
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<wicri:regionArea>Université Victor Ségalen-Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in the affected brain regions, of protein inclusions named Lewy Bodies. Despite the fact that numerous mutations causing hereditary forms of Parkinson's disease have been identified in the last decade, current transgenic animal models do not adequately reproduce cardinal features of the human disease. Altogether, the animal models derived of human mutations indicate that the nigrostriatal degenerative process results from the combination of several mechanisms that implicate mitochondrial dysfunction, oxidative damage, and protein degradation impairment.</div>
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