Subthalamic Nucleus Stimulation Affects Fear and Sadness Recognition in Parkinson's Disease
Identifieur interne : 001D15 ( Main/Exploration ); précédent : 001D14; suivant : 001D16Subthalamic Nucleus Stimulation Affects Fear and Sadness Recognition in Parkinson's Disease
Auteurs : Julie Peron [France] ; Isabelle Biseul [France] ; Emmanuelle Leray [France] ; Florence Le Jeune [France] ; Dominique Drapier [France] ; Siobhan Vicente [France] ; Sophie Drapier [France] ; Paul Sauleau [France] ; Claire Haegelen [France] ; Marc Verin [France]Source :
- Neuropsychology [ 0894-4105 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Deep brain stimulation, Electric Stimulation Therapy, Emotion emotionality, Experimental study, Fear, Female, Human, Humans, Limbic system, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson disease, Recognition, Recognition (Psychology) (physiology), Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, Treatment Outcome.
- MESH :
- complications : Parkinson Disease.
- physiology : Recognition (Psychology), Subthalamic Nucleus.
- Aged, Analysis of Variance, Electric Stimulation Therapy, Fear, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Treatment Outcome.
Abstract
Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) can produce emotional disorders that have been linked to disturbance of the STN's limbic territory. The aim of this study was to confirm the impairment of the recognition of facial emotions (RFE) induced by STN DBS, not only ruling out the effect of the disease's natural progression in relation to the effect of DBS, but also assessing the influence of modifications in dopamine replacement therapy (DRT) following STN DBS. RFE was investigated in 24 PD patients who underwent STN DBS and 20 PD patients treated with apomorphine. They were assessed 3 months before and after treatment. The 2 patient groups were compared with a group of 30 healthy matched controls. The results showed that RFE for negative emotions (fear and sadness) was impaired in only the STN DBS group in the posttreatment condition and was unrelated to DRT. Results confirm the selective reduction of RFE induced by STN DBS, due neither to the disease's natural progression nor to modifications in DRT.
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Biseul</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation></author><author><name sortKey="Leray, Emmanuelle" sort="Leray, Emmanuelle" uniqKey="Leray E" first="Emmanuelle" last="Leray">Emmanuelle Leray</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation></author><author><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Eugène Marquis</s1><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Eugène Marquis</wicri:noRegion><wicri:noRegion>Centre Eugène Marquis</wicri:noRegion></affiliation></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Eugène Marquis</s1><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Eugène Marquis</wicri:noRegion><wicri:noRegion>Centre Eugène Marquis</wicri:noRegion></affiliation></author><author><name sortKey="Vicente, 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aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Guillaume Régnier</wicri:noRegion><wicri:noRegion>Centre Hospitalier Guillaume Régnier</wicri:noRegion></affiliation></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre Hospitalier Universitaire de Rennes</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion><wicri:noRegion>Centre Hospitalier Universitaire de Rennes</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuropsychology</title><title level="j" type="abbreviated">Neuropsychology</title><idno type="ISSN">0894-4105</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuropsychology</title><title level="j" type="abbreviated">Neuropsychology</title><idno type="ISSN">0894-4105</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Deep brain stimulation</term><term>Electric Stimulation Therapy</term><term>Emotion emotionality</term><term>Experimental study</term><term>Fear</term><term>Female</term><term>Human</term><term>Humans</term><term>Limbic system</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Recognition</term><term>Recognition (Psychology) (physiology)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Recognition (Psychology)</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electric Stimulation Therapy</term><term>Fear</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Noyau sousthalamique</term><term>Peur</term><term>Emotion émotivité</term><term>Reconnaissance</term><term>Maladie de Parkinson</term><term>Système limbique</term><term>Etude expérimentale</term><term>Homme</term><term>Tristesse</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) can produce emotional disorders that have been linked to disturbance of the STN's limbic territory. The aim of this study was to confirm the impairment of the recognition of facial emotions (RFE) induced by STN DBS, not only ruling out the effect of the disease's natural progression in relation to the effect of DBS, but also assessing the influence of modifications in dopamine replacement therapy (DRT) following STN DBS. RFE was investigated in 24 PD patients who underwent STN DBS and 20 PD patients treated with apomorphine. They were assessed 3 months before and after treatment. The 2 patient groups were compared with a group of 30 healthy matched controls. The results showed that RFE for negative emotions (fear and sadness) was impaired in only the STN DBS group in the posttreatment condition and was unrelated to DRT. Results confirm the selective reduction of RFE induced by STN DBS, due neither to the disease's natural progression nor to modifications in DRT.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Peron">Julie Peron</name></noRegion><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><name sortKey="Leray, Emmanuelle" sort="Leray, Emmanuelle" uniqKey="Leray E" first="Emmanuelle" last="Leray">Emmanuelle Leray</name><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name><name sortKey="Vicente, Siobhan" sort="Vicente, Siobhan" uniqKey="Vicente S" first="Siobhan" last="Vicente">Siobhan Vicente</name><name sortKey="Vicente, Siobhan" sort="Vicente, Siobhan" uniqKey="Vicente S" first="Siobhan" last="Vicente">Siobhan Vicente</name><name sortKey="Vicente, Siobhan" sort="Vicente, Siobhan" uniqKey="Vicente S" first="Siobhan" last="Vicente">Siobhan Vicente</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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