Does ageing influence deep brain stimulation outcomes in Parkinson's disease?
Identifieur interne : 002831 ( Main/Exploration ); précédent : 002830; suivant : 002832Does ageing influence deep brain stimulation outcomes in Parkinson's disease?
Auteurs : Fabienne Ory-Magne [France] ; Christine Brefel-Courbon [France] ; Marion Simonetta-Moreau [France] ; Nelly Fabre [France] ; Jean Albert Lotterie [France] ; Patrick Chaynes [France] ; Isabelle Berry [France] ; Yves Lazorthes [France] ; Olivier Rascol [France]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Ageing, Aging, Deep Brain Stimulation (methods), Deep brain stimulation, Female, Humans, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (therapy), Parkinson disease, Prognosis, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Subthalamic nucleus, Treatment Outcome.
- MESH :
- methods : Deep Brain Stimulation.
- therapy : Parkinson Disease.
- Adult, Aged, Aging, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome.
Abstract
We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.
Affiliations:
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Le document en format XML
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Ageing</term>
<term>Aging</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Deep brain stimulation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
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<term>Quality of Life</term>
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<term>Statistics, Nonparametric</term>
<term>Subthalamic nucleus</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.</div>
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<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
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<name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
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