ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000D70

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Identifieur interne : 000D70 ( PubMed/Corpus ); précédent : 000D69; suivant : 000D71

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Auteurs : Fabienne Ory-Magne ; Christine Brefel-Courbon ; Marion Simonetta-Moreau ; Nelly Fabre ; Jean Albert Lotterie ; Patrick Chaynes ; Isabelle Berry ; Yves Lazorthes ; Olivier Rascol

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17516457

English descriptors

KwdEn :
- Adult, Aged, Aging, Deep Brain Stimulation (methods), Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (therapy), Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome.
MESH :
- methods : Deep Brain Stimulation.
- therapy : Parkinson Disease.
- Adult, Aged, Aging, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome.

Abstract

We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 +/- 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.

DOI: 10.1002/mds.21547
PubMed: 17516457

Links to Exploration step

pubmed:17516457

Le document en format XML

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<author><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
<affiliation><nlm:affiliation>Department of Neurology, University Hospital CHU, Toulouse, France. ory.f@chu-toulouse.fr</nlm:affiliation>
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<author><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
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<author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
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<author><name sortKey="Fabre, Nelly" sort="Fabre, Nelly" uniqKey="Fabre N" first="Nelly" last="Fabre">Nelly Fabre</name>
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<author><name sortKey="Lotterie, Jean Albert" sort="Lotterie, Jean Albert" uniqKey="Lotterie J" first="Jean Albert" last="Lotterie">Jean Albert Lotterie</name>
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<author><name sortKey="Chaynes, Patrick" sort="Chaynes, Patrick" uniqKey="Chaynes P" first="Patrick" last="Chaynes">Patrick Chaynes</name>
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<author><name sortKey="Berry, Isabelle" sort="Berry, Isabelle" uniqKey="Berry I" first="Isabelle" last="Berry">Isabelle Berry</name>
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<author><name sortKey="Lazorthes, Yves" sort="Lazorthes, Yves" uniqKey="Lazorthes Y" first="Yves" last="Lazorthes">Yves Lazorthes</name>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Parkinson Disease (therapy)</term>
<term>Quality of Life</term>
<term>Severity of Illness Index</term>
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<term>Aging</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
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<front><div type="abstract" xml:lang="en">We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 +/- 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.</div>
</front>
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<ArticleTitle>Does ageing influence deep brain stimulation outcomes in Parkinson's disease?</ArticleTitle>
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<Abstract><AbstractText>We sought to define the influence of ageing in clinical, cognitive, and quality-of-life outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ-39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 +/- 9 years, range 40-73). No significant correlation was found between age and motor scores and PDQ-39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN-DBS is an effective treatment for elderly patients with advanced PD. A longer follow-up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage.</AbstractText>
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Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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