Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue
Identifieur interne : 003097 ( Main/Exploration ); précédent : 003096; suivant : 003098Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue
Auteurs : Valérie Cochen [France] ; Maria-Joao Ribeiro [France] ; Jean-Paul Nguyen [France] ; Jean-Marc Gurruchaga [France] ; Gabriel Villafane [France] ; Christian Loc'H [France] ; Gilles Defer [France] ; Yves Samson [France] ; Marc Peschanski [France] ; Philippe Hantraye [France] ; Pierre Cesaro [France] ; Philippe Remy [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Autograft, Biological transport, CIT, Cell therapy, Corpus Striatum (metabolism), Dopamine, Dopamine Plasma Membrane Transport Proteins, Female, Fetal Tissue Transplantation (methods), Fetal cell, Fluorodeoxyglucose F18 (pharmacokinetics), Graft Rejection (prevention & control), Humans, Immunosuppressive Agents (therapeutic use), Ligand, Male, Mechanism of action, Membrane Glycoproteins, Membrane Transport Proteins (metabolism), Mesencephalon (embryology), Mesencephalon (metabolism), Mesencephalon (transplantation), Midbrain, Middle Aged, Nerve Tissue Proteins, PET, Parkinson, Parkinson Disease (diagnosis), Parkinson Disease (surgery), Parkinson disease, Positron emission tomography, Radiopharmaceuticals (pharmacokinetics), Tomography, Emission-Computed, Treatment, dopamine transporter, fetal transplantation.
- MESH :
- chemical , metabolism : Membrane Transport Proteins.
- chemical , pharmacokinetics : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , therapeutic use : Immunosuppressive Agents.
- chemical : Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Nerve Tissue Proteins.
- diagnosis : Parkinson Disease.
- embryology : Mesencephalon.
- metabolism : Corpus Striatum, Mesencephalon.
- methods : Fetal Tissue Transplantation.
- prevention & control : Graft Rejection.
- surgery : Parkinson Disease.
- transplantation : Mesencephalon.
- Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.
Abstract
An erratum for this article appears in the January, 2004 issue of Movement Disorders (Mov Disord 2004;12:119). We compared the striatal uptake of [18F]fluorodopa with [76Br]‐FE‐CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [18F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [18F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [18F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10463
Affiliations:
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Le document en format XML
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<term>Aged</term>
<term>Autograft</term>
<term>Biological transport</term>
<term>CIT</term>
<term>Cell therapy</term>
<term>Corpus Striatum (metabolism)</term>
<term>Dopamine</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Fetal Tissue Transplantation (methods)</term>
<term>Fetal cell</term>
<term>Fluorodeoxyglucose F18 (pharmacokinetics)</term>
<term>Graft Rejection (prevention & control)</term>
<term>Humans</term>
<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Ligand</term>
<term>Male</term>
<term>Mechanism of action</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins (metabolism)</term>
<term>Mesencephalon (embryology)</term>
<term>Mesencephalon (metabolism)</term>
<term>Mesencephalon (transplantation)</term>
<term>Midbrain</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins</term>
<term>PET</term>
<term>Parkinson</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Positron emission tomography</term>
<term>Radiopharmaceuticals (pharmacokinetics)</term>
<term>Tomography, Emission-Computed</term>
<term>Treatment</term>
<term>dopamine transporter</term>
<term>fetal transplantation</term>
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<term>Membrane Glycoproteins</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Autogreffe</term>
<term>Cellule foetale</term>
<term>Dopamine</term>
<term>Ligand</term>
<term>Mécanisme action</term>
<term>Mésencéphale</term>
<term>Parkinson maladie</term>
<term>Thérapie cellulaire</term>
<term>Tomographie émission positon</term>
<term>Traitement</term>
<term>Transport biologique</term>
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<front><div type="abstract" xml:lang="en">An erratum for this article appears in the January, 2004 issue of Movement Disorders (Mov Disord 2004;12:119). We compared the striatal uptake of [18F]fluorodopa with [76Br]‐FE‐CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [18F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [18F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [18F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation. © 2003 Movement Disorder Society</div>
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<settlement><li>Caen</li>
<li>Créteil</li>
<li>Orsay</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Cochen, Valerie" sort="Cochen, Valerie" uniqKey="Cochen V" first="Valérie" last="Cochen">Valérie Cochen</name>
</noRegion>
<name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name>
<name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name>
<name sortKey="Defer, Gilles" sort="Defer, Gilles" uniqKey="Defer G" first="Gilles" last="Defer">Gilles Defer</name>
<name sortKey="Defer, Gilles" sort="Defer, Gilles" uniqKey="Defer G" first="Gilles" last="Defer">Gilles Defer</name>
<name sortKey="Gurruchaga, Jean Arc" sort="Gurruchaga, Jean Arc" uniqKey="Gurruchaga J" first="Jean-Marc" last="Gurruchaga">Jean-Marc Gurruchaga</name>
<name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
<name sortKey="Loc H, Christian" sort="Loc H, Christian" uniqKey="Loc H C" first="Christian" last="Loc'H">Christian Loc'H</name>
<name sortKey="Nguyen, Jean Aul" sort="Nguyen, Jean Aul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name>
<name sortKey="Nguyen, Jean Aul" sort="Nguyen, Jean Aul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name>
<name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name>
<name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name>
<name sortKey="Ribeiro, Maria Oao" sort="Ribeiro, Maria Oao" uniqKey="Ribeiro M" first="Maria-Joao" last="Ribeiro">Maria-Joao Ribeiro</name>
<name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name>
<name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name>
<name sortKey="Villafane, Gabriel" sort="Villafane, Gabriel" uniqKey="Villafane G" first="Gabriel" last="Villafane">Gabriel Villafane</name>
</country>
</tree>
</affiliations>
</record>
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