Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue
Identifieur interne : 000D34 ( PascalFrancis/Checkpoint ); précédent : 000D33; suivant : 000D35Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue
Auteurs : Valérie Cochen [France] ; Maria-Joao Ribeiro [France] ; Jean-Paul Nguyen [France] ; Jean-Marc Gurruchaga [France] ; Gabriel Villafane [France] ; Christian Loc'H [France] ; Gilles Defer [France] ; Yves Samson [France] ; Marc Peschanski [France] ; Philippe Hantraye [France] ; Pierre Cesaro [France] ; Philippe Remy [France]Source :
- Movement disorders [ 0885-3185 ] ; 2003.
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Abstract
We compared the striatal uptake of [18F]fluorodopa with [76Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [18F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [18F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [18F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.
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tissue</title><author><name sortKey="Cochen, Valerie" sort="Cochen, Valerie" uniqKey="Cochen V" first="Valérie" last="Cochen">Valérie Cochen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique 2210</s1><s2>Orsay</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Ribeiro, Maria Joao" sort="Ribeiro, Maria Joao" uniqKey="Ribeiro M" first="Maria-Joao" last="Ribeiro">Maria-Joao Ribeiro</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CEA, Direction des Sciences du Vivant/Département de Recherche Médicale, Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Nguyen, Jean Paul" sort="Nguyen, Jean Paul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale U421, Faculté de Médecine</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Gurruchaga, Jean Marc" sort="Gurruchaga, Jean Marc" uniqKey="Gurruchaga J" first="Jean-Marc" last="Gurruchaga">Jean-Marc Gurruchaga</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Villafane, Gabriel" sort="Villafane, Gabriel" uniqKey="Villafane G" first="Gabriel" last="Villafane">Gabriel Villafane</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Loc H, Christian" sort="Loc H, Christian" uniqKey="Loc H C" first="Christian" last="Loc'H">Christian Loc'H</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CEA, Direction des Sciences du Vivant/Département de Recherche Médicale, Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Defer, Gilles" sort="Defer, Gilles" uniqKey="Defer G" first="Gilles" last="Defer">Gilles Defer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service de Neurologie Déjerine</s1><s2>Caen</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CEA, Direction des Sciences du Vivant/Département de Recherche Médicale, Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Urgences Cérébro-Vasculaires, CHU Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale U421, Faculté de Médecine</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique 2210</s1><s2>Orsay</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale U421, Faculté de Médecine</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique 2210</s1><s2>Orsay</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CEA, Direction des Sciences du Vivant/Département de Recherche Médicale, Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Autograft</term><term>Biological transport</term><term>Cell therapy</term><term>Dopamine</term><term>Fetal cell</term><term>Ligand</term><term>Mechanism of action</term><term>Midbrain</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Autogreffe</term><term>Mésencéphale</term><term>Cellule foetale</term><term>Tomographie émission positon</term><term>Ligand</term><term>Transport biologique</term><term>Dopamine</term><term>Parkinson maladie</term><term>Thérapie cellulaire</term><term>Traitement</term><term>Mécanisme action</term><term>Adulte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the striatal uptake of [<sup>18</sup>F]fluorodopa with [<sup>76</sup>Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [<sup>18</sup>F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [<sup>18</sup>F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [<sup>18</sup>F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>18</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue</s1></fA08><fA11 i1="01" i2="1"><s1>COCHEN (Valérie)</s1></fA11><fA11 i1="02" i2="1"><s1>RIBEIRO (Maria-Joao)</s1></fA11><fA11 i1="03" i2="1"><s1>NGUYEN (Jean-Paul)</s1></fA11><fA11 i1="04" i2="1"><s1>GURRUCHAGA (Jean-Marc)</s1></fA11><fA11 i1="05" i2="1"><s1>VILLAFANE (Gabriel)</s1></fA11><fA11 i1="06" i2="1"><s1>LOC'H (Christian)</s1></fA11><fA11 i1="07" i2="1"><s1>DEFER (Gilles)</s1></fA11><fA11 i1="08" i2="1"><s1>SAMSON (Yves)</s1></fA11><fA11 i1="09" i2="1"><s1>PESCHANSKI (Marc)</s1></fA11><fA11 i1="10" i2="1"><s1>HANTRAYE (Philippe)</s1></fA11><fA11 i1="11" i2="1"><s1>CESARO (Pierre)</s1></fA11><fA11 i1="12" i2="1"><s1>REMY (Philippe)</s1></fA11><fA14 i1="01"><s1>Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique 2210</s1><s2>Orsay</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="02"><s1>CEA, Direction des Sciences du Vivant/Département de Recherche Médicale, Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="03"><s1>Département de Neurosciences, Centre Hospitalier Universitaire (CHU) Henri Mondor, AP-HP et Faculté de Médecine Paris-XII</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="04"><s1>Institut National de la Santé et de la Recherche Médicale U421, Faculté de Médecine</s1><s2>Créteil</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="05"><s1>Service de Neurologie Déjerine</s1><s2>Caen</s2><s3>FRA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Urgences Cérébro-Vasculaires, CHU Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>928-932</s1></fA20><fA21><s1>2003</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000112695530120</s5></fA43><fA44><s0>0000</s0><s1>© 2004 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>20 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>04-0010352</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We compared the striatal uptake of [<sup>18</sup>F]fluorodopa with [<sup>76</sup>Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [<sup>18</sup>F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [<sup>18</sup>F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [<sup>18</sup>F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.</s0></fC01><fC02 i1="01" i2="X"><s0>002B27D03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Autogreffe</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Autograft</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Autoinjerto</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Mésencéphale</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Midbrain</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Mesencéfalo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Cellule foetale</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Fetal cell</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Célula fetal</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tomographie émission positon</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Positron emission tomography</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Ligand</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Ligand</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Ligando</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Transport biologique</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Biological transport</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Transporte biológico</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Dopamina</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Thérapie cellulaire</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Cell therapy</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Terapia celular</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Traitement</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Treatment</s0><s5>18</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Mécanisme action</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Mechanism of action</s0><s5>19</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Mecanismo acción</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Adulte</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Adult</s0><s5>20</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Adulto</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Greffe</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Graft</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Injerto</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Exploration radioisotopique</s0><s5>45</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Radionuclide study</s0><s5>45</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Exploración radioisotópica</s0><s5>45</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>61</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>61</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>61</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>62</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>62</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>62</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>63</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>63</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>63</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>64</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>64</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>64</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>65</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>65</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>65</s5></fC07><fN21><s1>006</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Caen</li><li>Créteil</li><li>Orsay</li><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Cochen, Valerie" sort="Cochen, Valerie" uniqKey="Cochen V" first="Valérie" last="Cochen">Valérie Cochen</name></noRegion><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><name sortKey="Defer, Gilles" sort="Defer, Gilles" uniqKey="Defer G" first="Gilles" last="Defer">Gilles Defer</name><name sortKey="Defer, Gilles" sort="Defer, Gilles" uniqKey="Defer G" first="Gilles" last="Defer">Gilles Defer</name><name sortKey="Gurruchaga, Jean Marc" sort="Gurruchaga, Jean Marc" uniqKey="Gurruchaga J" first="Jean-Marc" last="Gurruchaga">Jean-Marc Gurruchaga</name><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><name sortKey="Loc H, Christian" sort="Loc H, Christian" uniqKey="Loc H C" first="Christian" last="Loc'H">Christian Loc'H</name><name sortKey="Nguyen, Jean Paul" sort="Nguyen, Jean Paul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name><name sortKey="Nguyen, Jean Paul" sort="Nguyen, Jean Paul" uniqKey="Nguyen J" first="Jean-Paul" last="Nguyen">Jean-Paul Nguyen</name><name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name><name sortKey="Peschanski, Marc" sort="Peschanski, Marc" uniqKey="Peschanski M" first="Marc" last="Peschanski">Marc Peschanski</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><name sortKey="Ribeiro, Maria Joao" sort="Ribeiro, Maria Joao" uniqKey="Ribeiro M" first="Maria-Joao" last="Ribeiro">Maria-Joao Ribeiro</name><name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name><name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name><name sortKey="Villafane, Gabriel" sort="Villafane, Gabriel" uniqKey="Villafane G" first="Gabriel" last="Villafane">Gabriel Villafane</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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