Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease
Identifieur interne : 003697 ( Main/Exploration ); précédent : 003696; suivant : 003698Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease
Auteurs : Laurent Pezard [France] ; Robert Jech [République tchèque] ; Evžen Růži Ka [République tchèque]Source :
- Clinical Neurophysiology [ 1388-2457 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Algorithms, Antiparkinson Agents (therapeutic use), Dopamine, EEG, Electrodiagnosis, Electroencephalography, Entropy, Female, Human, Humans, Male, Middle Aged, Multichannel recording, Non linear properties, Non-linear dynamics, Nonlinear Dynamics, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Psychiatric Status Rating Scales, Spectral analysis, Surrogate data.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Algorithms, Electroencephalography, Entropy, Female, Humans, Male, Middle Aged, Nonlinear Dynamics, Psychiatric Status Rating Scales.
Abstract
Objectives: Modifications of brain activity in the early stages of Parkinson's disease (PD) are difficult to detect using electroencephalography (EEG) signals and are often biased by l-DOPA treatment. We compare here the performances of both linear and non-linear methods in differentiating EEG of l-DOPA naive PD patients from that of control subjects. Methods: Resting multichannel EEG (20 electrodes, 30 s epochs) of 9 patients with PD in Hoehn and Yahr stages 1–2 (4 women, 5 men, mean age 54.3 years, range 48–63 years) were compared with those of 9 control subjects (7 women, two men, mean age 51.3 years, range 43–61 years). The following measurements were computed: θ-, α- and β-band relative powers constituted the linear indices; localized entropy, slope asymmetry and number of non-linear EEG segments constituted the non-linear indices. Results: In the case of linear quantification, only a decrease in the β-band was observed for patients. Significant non-linear structures were observed in our EEG data. Non-linear quantifiers demonstrate an increase in entropy and in the number of non-linear EEG segments for the patients. Conclusions: Changes in EEG dynamics observed here in l-DOPA naive PD patients may represent early signs of cortical dysfunction produced by subcortical dopamine depletion.
Url:
DOI: 10.1016/S1388-2457(00)00512-5
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Objectives: Modifications of brain activity in the early stages of Parkinson's disease (PD) are difficult to detect using electroencephalography (EEG) signals and are often biased by l-DOPA treatment. We compare here the performances of both linear and non-linear methods in differentiating EEG of l-DOPA naive PD patients from that of control subjects. Methods: Resting multichannel EEG (20 electrodes, 30 s epochs) of 9 patients with PD in Hoehn and Yahr stages 1–2 (4 women, 5 men, mean age 54.3 years, range 48–63 years) were compared with those of 9 control subjects (7 women, two men, mean age 51.3 years, range 43–61 years). The following measurements were computed: θ-, α- and β-band relative powers constituted the linear indices; localized entropy, slope asymmetry and number of non-linear EEG segments constituted the non-linear indices. Results: In the case of linear quantification, only a decrease in the β-band was observed for patients. Significant non-linear structures were observed in our EEG data. Non-linear quantifiers demonstrate an increase in entropy and in the number of non-linear EEG segments for the patients. Conclusions: Changes in EEG dynamics observed here in l-DOPA naive PD patients may represent early signs of cortical dysfunction produced by subcortical dopamine depletion.</div>
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