Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease
Identifieur interne : 003697 ( Main/Exploration ); précédent : 003696; suivant : 003698Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease
Auteurs : Laurent Pezard [France] ; Robert Jech [République tchèque] ; Evžen Růži Ka [République tchèque]Source :
- Clinical Neurophysiology [ 1388-2457 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Algorithms, Antiparkinson Agents (therapeutic use), Dopamine, EEG, Electrodiagnosis, Electroencephalography, Entropy, Female, Human, Humans, Male, Middle Aged, Multichannel recording, Non linear properties, Non-linear dynamics, Nonlinear Dynamics, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Psychiatric Status Rating Scales, Spectral analysis, Surrogate data.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Algorithms, Electroencephalography, Entropy, Female, Humans, Male, Middle Aged, Nonlinear Dynamics, Psychiatric Status Rating Scales.
Abstract
Objectives: Modifications of brain activity in the early stages of Parkinson's disease (PD) are difficult to detect using electroencephalography (EEG) signals and are often biased by l-DOPA treatment. We compare here the performances of both linear and non-linear methods in differentiating EEG of l-DOPA naive PD patients from that of control subjects. Methods: Resting multichannel EEG (20 electrodes, 30 s epochs) of 9 patients with PD in Hoehn and Yahr stages 1–2 (4 women, 5 men, mean age 54.3 years, range 48–63 years) were compared with those of 9 control subjects (7 women, two men, mean age 51.3 years, range 43–61 years). The following measurements were computed: θ-, α- and β-band relative powers constituted the linear indices; localized entropy, slope asymmetry and number of non-linear EEG segments constituted the non-linear indices. Results: In the case of linear quantification, only a decrease in the β-band was observed for patients. Significant non-linear structures were observed in our EEG data. Non-linear quantifiers demonstrate an increase in entropy and in the number of non-linear EEG segments for the patients. Conclusions: Changes in EEG dynamics observed here in l-DOPA naive PD patients may represent early signs of cortical dysfunction produced by subcortical dopamine depletion.
Url:
DOI: 10.1016/S1388-2457(00)00512-5
Affiliations:
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Le document en format XML
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multichannel EEG in the early stages of Parkinson's disease</title><author><name sortKey="Pezard, Laurent" sort="Pezard, Laurent" uniqKey="Pezard L" first="Laurent" last="Pezard">Laurent Pezard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurosciences Comportementales, Université René Descartes, 45 rue des Saints-Pères, F-75270 Paris Cedex 06</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jech, Robert" sort="Jech, Robert" uniqKey="Jech R" first="Robert" last="Jech">Robert Jech</name><affiliation wicri:level="1"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Clinic of Neurology, Charles University, Kateřinská 30, CZ-120 00 Praha 2</wicri:regionArea><wicri:noRegion>CZ-120 00 Praha 2</wicri:noRegion></affiliation></author><author><name sortKey="Ruzi Ka, Evzen" sort="Ruzi 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analysis</term><term>Surrogate data</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Electroencephalography</term><term>Entropy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nonlinear Dynamics</term><term>Psychiatric Status Rating Scales</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Analyse spectrale</term><term>Dopamine</term><term>Electrodiagnostic</term><term>Electroencéphalographie</term><term>Enregistrement multicanal</term><term>Homme</term><term>Parkinson maladie</term><term>Propriété non linéaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Modifications of brain activity in the early stages of Parkinson's disease (PD) are difficult to detect using electroencephalography (EEG) signals and are often biased by l-DOPA treatment. We compare here the performances of both linear and non-linear methods in differentiating EEG of l-DOPA naive PD patients from that of control subjects. Methods: Resting multichannel EEG (20 electrodes, 30 s epochs) of 9 patients with PD in Hoehn and Yahr stages 1–2 (4 women, 5 men, mean age 54.3 years, range 48–63 years) were compared with those of 9 control subjects (7 women, two men, mean age 51.3 years, range 43–61 years). The following measurements were computed: θ-, α- and β-band relative powers constituted the linear indices; localized entropy, slope asymmetry and number of non-linear EEG segments constituted the non-linear indices. Results: In the case of linear quantification, only a decrease in the β-band was observed for patients. Significant non-linear structures were observed in our EEG data. Non-linear quantifiers demonstrate an increase in entropy and in the number of non-linear EEG segments for the patients. Conclusions: Changes in EEG dynamics observed here in l-DOPA naive PD patients may represent early signs of cortical dysfunction produced by subcortical dopamine depletion.</div></front></TEI><affiliations><list><country><li>France</li><li>République tchèque</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Pezard, Laurent" sort="Pezard, Laurent" uniqKey="Pezard L" first="Laurent" last="Pezard">Laurent Pezard</name></region></country><country name="République tchèque"><noRegion><name sortKey="Jech, Robert" sort="Jech, Robert" uniqKey="Jech R" first="Robert" last="Jech">Robert Jech</name></noRegion><name sortKey="Ruzi Ka, Evzen" sort="Ruzi Ka, Evzen" uniqKey="Ruzi Ka E" first="Evžen" last="Růži Ka">Evžen Růži Ka</name><name sortKey="Ruzi Ka, Evzen" sort="Ruzi Ka, Evzen" uniqKey="Ruzi Ka E" first="Evžen" last="Růži Ka">Evžen Růži Ka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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