Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
Identifieur interne : 003879 ( Main/Exploration ); précédent : 003878; suivant : 003880Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
Auteurs : P. Krack [France] ; P L Dowsey ; A L Benabid ; N. Acarin ; A. Benazzouz ; G. Künig ; K L Leenders ; J A Obeso ; P. PollakSource :
- Neurology [ 0028-3878 ] ; 2000.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Drug Resistance, Electric Stimulation, Globus Pallidus (pathology), Humans, Levodopa (therapeutic use), Male, Middle Aged, Myocardial Ischemia (complications), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (surgery), Subthalamic Nucleus (pathology), Subthalamic Nucleus (surgery).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Myocardial Ischemia.
- drug therapy : Parkinson Disease, Secondary.
- etiology : Parkinson Disease, Secondary.
- pathology : Globus Pallidus, Subthalamic Nucleus.
- surgery : Parkinson Disease, Secondary, Subthalamic Nucleus.
- Drug Resistance, Electric Stimulation, Humans, Male, Middle Aged.
Abstract
The authors report a patient with postischemic parkinsonism who responded neither to levodopa nor to bilateral subthalamic nucleus (STN) stimulation. MRI revealed bilateral lesions of the substantia nigra, the striatum, the external pallidum, and part of the internal pallidum. PET showed reduced striatal dopa-decarboxylase activity, D2 receptor binding, and glucose metabolism. Perioperative microrecording showed low-frequency activity of STN cells. This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery.
PubMed: 10851392
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001309
- to stream PubMed, to step Curation: 001268
- to stream PubMed, to step Checkpoint: 001268
- to stream Ncbi, to step Merge: 000121
- to stream Ncbi, to step Curation: 000121
- to stream Ncbi, to step Checkpoint: 000121
- to stream Main, to step Merge: 003F04
- to stream Main, to step Curation: 003879
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.</title><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France. p.krack@neurologie.uni-kiel.de</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Dowsey, P L" sort="Dowsey, P L" uniqKey="Dowsey P" first="P L" last="Dowsey">P L Dowsey</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Acarin, N" sort="Acarin, N" uniqKey="Acarin N" first="N" last="Acarin">N. Acarin</name></author><author><name sortKey="Benazzouz, A" sort="Benazzouz, A" uniqKey="Benazzouz A" first="A" last="Benazzouz">A. Benazzouz</name></author><author><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name></author><author><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K L" last="Leenders">K L Leenders</name></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J A" last="Obeso">J A Obeso</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10851392</idno><idno type="pmid">10851392</idno><idno type="wicri:Area/PubMed/Corpus">001309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001309</idno><idno type="wicri:Area/PubMed/Curation">001268</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001268</idno><idno type="wicri:Area/PubMed/Checkpoint">001268</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001268</idno><idno type="wicri:Area/Ncbi/Merge">000121</idno><idno type="wicri:Area/Ncbi/Curation">000121</idno><idno type="wicri:Area/Ncbi/Checkpoint">000121</idno><idno type="wicri:doubleKey">0028-3878:2000:Krack P:ineffective:subthalamic:nucleus</idno><idno type="wicri:Area/Main/Merge">003F04</idno><idno type="wicri:Area/Main/Curation">003879</idno><idno type="wicri:Area/Main/Exploration">003879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.</title><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France. p.krack@neurologie.uni-kiel.de</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Dowsey, P L" sort="Dowsey, P L" uniqKey="Dowsey P" first="P L" last="Dowsey">P L Dowsey</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Acarin, N" sort="Acarin, N" uniqKey="Acarin N" first="N" last="Acarin">N. Acarin</name></author><author><name sortKey="Benazzouz, A" sort="Benazzouz, A" uniqKey="Benazzouz A" first="A" last="Benazzouz">A. Benazzouz</name></author><author><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name></author><author><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K L" last="Leenders">K L Leenders</name></author><author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J A" last="Obeso">J A Obeso</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Drug Resistance</term><term>Electric Stimulation</term><term>Globus Pallidus (pathology)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Myocardial Ischemia (complications)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Parkinson Disease, Secondary (etiology)</term><term>Parkinson Disease, Secondary (surgery)</term><term>Subthalamic Nucleus (pathology)</term><term>Subthalamic Nucleus (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Myocardial Ischemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Globus Pallidus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease, Secondary</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance</term><term>Electric Stimulation</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors report a patient with postischemic parkinsonism who responded neither to levodopa nor to bilateral subthalamic nucleus (STN) stimulation. MRI revealed bilateral lesions of the substantia nigra, the striatum, the external pallidum, and part of the internal pallidum. PET showed reduced striatal dopa-decarboxylase activity, D2 receptor binding, and glucose metabolism. Perioperative microrecording showed low-frequency activity of STN cells. This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement></list><tree><noCountry><name sortKey="Acarin, N" sort="Acarin, N" uniqKey="Acarin N" first="N" last="Acarin">N. Acarin</name><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name><name sortKey="Benazzouz, A" sort="Benazzouz, A" uniqKey="Benazzouz A" first="A" last="Benazzouz">A. Benazzouz</name><name sortKey="Dowsey, P L" sort="Dowsey, P L" uniqKey="Dowsey P" first="P L" last="Dowsey">P L Dowsey</name><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K L" last="Leenders">K L Leenders</name><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J A" last="Obeso">J A Obeso</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003879 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003879 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:10851392
|texte= Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10851392" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |