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A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse

Identifieur interne : 003F36 ( Main/Exploration ); précédent : 003F35; suivant : 003F37

A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse

Auteurs : J. A. Aguirre [Espagne] ; A. Cintra [Suède] ; J. Hillion [Suède] ; J. A. Narvaez [Espagne] ; A. Jansson [Suède] ; T. Antonelli [Italie] ; L. Ferraro [Italie] ; F. A. Rambert [France] ; K. Fuxe [Suède]

Source :

Neuroscience letters [ 0304-3940 ] ; 1999.

RBID : Pascal:99-0547776

Descripteurs français

Pascal (Inist)
- Lésion, Locus niger, Modafinil, Neuroprotecteur, Stéréologie, Dopamine, Parkinson maladie, Modèle animal, Mâle, MPTP.

English descriptors

KwdEn :
- Animal model, Dopamine, Lesion, Locus niger, Male, Modafinil, Neuroprotective agent, Parkinson disease, Stereology.

Abstract

The effect of an acute administration of the vigilance-promoting drug modafinil ((±)(diphenyl-methyl)-sulfinyl-2 acetamide ; Modiodal) on the nigrostriatal dopamine system was studied after damage induced by MPTP (1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by means of immunohistochemistry for tyrosine hydroxylase (TH) and a stereological method. MPTP (40 mg/kg) reduced from 24 380 ± 902 to 13 501 ± 522 and from 37 868 ± 3300 to 20 568 ± 1270, respectively, the number of TH immunoreactive (IR) and non-TH IR nigral neurons. Co-administration of Modafinil restored to normal the number of these neuronal populations. MPTP treatment induced also a reduction in the volume of TH IR neurons, which was counteracted by Modafinil administration. The data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of Modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-DA nerve cell population of the substantia nigra after MPTP lesion. These results suggest that Modafinil has a neuroprotective role in the substantia nigra via a still undefined mechanism in which a crucial role of DA uptake blockade should be excluded. Modafinil may therefore have a therapeutic potential in neurodegenerative processes such as those occurring in Parkinson's disease.

Affiliations:

Espagne, France, Italie, Suède

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The effect of an acute administration of the vigilance-promoting drug modafinil ((±)(diphenyl-methyl)-sulfinyl-2 acetamide ; Modiodal) on the nigrostriatal dopamine system was studied after damage induced by MPTP (1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by means of immunohistochemistry for tyrosine hydroxylase (TH) and a stereological method. MPTP (40 mg/kg) reduced from 24 380 ± 902 to 13 501 ± 522 and from 37 868 ± 3300 to 20 568 ± 1270, respectively, the number of TH immunoreactive (IR) and non-TH IR nigral neurons. Co-administration of Modafinil restored to normal the number of these neuronal populations. MPTP treatment induced also a reduction in the volume of TH IR neurons, which was counteracted by Modafinil administration. The data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of Modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-DA nerve cell population of the substantia nigra after MPTP lesion. These results suggest that Modafinil has a neuroprotective role in the substantia nigra via a still undefined mechanism in which a crucial role of DA uptake blockade should be excluded. Modafinil may therefore have a therapeutic potential in neurodegenerative processes such as those occurring in Parkinson's disease.</div>
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A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse

A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri