A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse
Identifieur interne : 001C04 ( PascalFrancis/Curation ); précédent : 001C03; suivant : 001C05A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse
Auteurs : J. A. Aguirre [Espagne] ; A. Cintra [Suède] ; J. Hillion [Suède] ; J. A. Narvaez [Espagne] ; A. Jansson [Suède] ; T. Antonelli [Italie] ; L. Ferraro [Italie] ; F. A. Rambert [France] ; K. Fuxe [Suède]Source :
- Neuroscience letters [ 0304-3940 ] ; 1999.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The effect of an acute administration of the vigilance-promoting drug modafinil ((±)(diphenyl-methyl)-sulfinyl-2 acetamide ; Modiodal) on the nigrostriatal dopamine system was studied after damage induced by MPTP (1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by means of immunohistochemistry for tyrosine hydroxylase (TH) and a stereological method. MPTP (40 mg/kg) reduced from 24 380 ± 902 to 13 501 ± 522 and from 37 868 ± 3300 to 20 568 ± 1270, respectively, the number of TH immunoreactive (IR) and non-TH IR nigral neurons. Co-administration of Modafinil restored to normal the number of these neuronal populations. MPTP treatment induced also a reduction in the volume of TH IR neurons, which was counteracted by Modafinil administration. The data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of Modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-DA nerve cell population of the substantia nigra after MPTP lesion. These results suggest that Modafinil has a neuroprotective role in the substantia nigra via a still undefined mechanism in which a crucial role of DA uptake blockade should be excluded. Modafinil may therefore have a therapeutic potential in neurodegenerative processes such as those occurring in Parkinson's disease.
pA |
|
---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001441
Links to Exploration step
Pascal:99-0547776Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse</title>
<author><name sortKey="Aguirre, J A" sort="Aguirre, J A" uniqKey="Aguirre J" first="J. A." last="Aguirre">J. A. Aguirre</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, School of Medicine</s1>
<s2>29080, Malaga</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Cintra, A" sort="Cintra, A" uniqKey="Cintra A" first="A." last="Cintra">A. Cintra</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Hillion, J" sort="Hillion, J" uniqKey="Hillion J" first="J." last="Hillion">J. Hillion</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Narvaez, J A" sort="Narvaez, J A" uniqKey="Narvaez J" first="J. A." last="Narvaez">J. A. Narvaez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, School of Medicine</s1>
<s2>29080, Malaga</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Jansson, A" sort="Jansson, A" uniqKey="Jansson A" first="A." last="Jansson">A. Jansson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Antonelli, T" sort="Antonelli, T" uniqKey="Antonelli T" first="T." last="Antonelli">T. Antonelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara</s1>
<s2>Ferrara</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Ferraro, L" sort="Ferraro, L" uniqKey="Ferraro L" first="L." last="Ferraro">L. Ferraro</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara</s1>
<s2>Ferrara</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Rambert, F A" sort="Rambert, F A" uniqKey="Rambert F" first="F. A." last="Rambert">F. A. Rambert</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Laboratoire L. Lafon</s1>
<s2>Maisons-Alfort</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fuxe, K" sort="Fuxe, K" uniqKey="Fuxe K" first="K." last="Fuxe">K. Fuxe</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0547776</idno>
<date when="1999">1999</date>
<idno type="stanalyst">PASCAL 99-0547776 INIST</idno>
<idno type="RBID">Pascal:99-0547776</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001441</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C04</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse</title>
<author><name sortKey="Aguirre, J A" sort="Aguirre, J A" uniqKey="Aguirre J" first="J. A." last="Aguirre">J. A. Aguirre</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, School of Medicine</s1>
<s2>29080, Malaga</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Cintra, A" sort="Cintra, A" uniqKey="Cintra A" first="A." last="Cintra">A. Cintra</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Hillion, J" sort="Hillion, J" uniqKey="Hillion J" first="J." last="Hillion">J. Hillion</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Narvaez, J A" sort="Narvaez, J A" uniqKey="Narvaez J" first="J. A." last="Narvaez">J. A. Narvaez</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Physiology, School of Medicine</s1>
<s2>29080, Malaga</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Jansson, A" sort="Jansson, A" uniqKey="Jansson A" first="A." last="Jansson">A. Jansson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Antonelli, T" sort="Antonelli, T" uniqKey="Antonelli T" first="T." last="Antonelli">T. Antonelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara</s1>
<s2>Ferrara</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Ferraro, L" sort="Ferraro, L" uniqKey="Ferraro L" first="L." last="Ferraro">L. Ferraro</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara</s1>
<s2>Ferrara</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Rambert, F A" sort="Rambert, F A" uniqKey="Rambert F" first="F. A." last="Rambert">F. A. Rambert</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Laboratoire L. Lafon</s1>
<s2>Maisons-Alfort</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fuxe, K" sort="Fuxe, K" uniqKey="Fuxe K" first="K." last="Fuxe">K. Fuxe</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term>
<term>Dopamine</term>
<term>Lesion</term>
<term>Locus niger</term>
<term>Male</term>
<term>Modafinil</term>
<term>Neuroprotective agent</term>
<term>Parkinson disease</term>
<term>Stereology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lésion</term>
<term>Locus niger</term>
<term>Modafinil</term>
<term>Neuroprotecteur</term>
<term>Stéréologie</term>
<term>Dopamine</term>
<term>Parkinson maladie</term>
<term>Modèle animal</term>
<term>Mâle</term>
<term>MPTP</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effect of an acute administration of the vigilance-promoting drug modafinil ((±)(diphenyl-methyl)-sulfinyl-2 acetamide ; Modiodal) on the nigrostriatal dopamine system was studied after damage induced by MPTP (1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by means of immunohistochemistry for tyrosine hydroxylase (TH) and a stereological method. MPTP (40 mg/kg) reduced from 24 380 ± 902 to 13 501 ± 522 and from 37 868 ± 3300 to 20 568 ± 1270, respectively, the number of TH immunoreactive (IR) and non-TH IR nigral neurons. Co-administration of Modafinil restored to normal the number of these neuronal populations. MPTP treatment induced also a reduction in the volume of TH IR neurons, which was counteracted by Modafinil administration. The data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of Modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-DA nerve cell population of the substantia nigra after MPTP lesion. These results suggest that Modafinil has a neuroprotective role in the substantia nigra via a still undefined mechanism in which a crucial role of DA uptake blockade should be excluded. Modafinil may therefore have a therapeutic potential in neurodegenerative processes such as those occurring in Parkinson's disease.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0304-3940</s0>
</fA01>
<fA02 i1="01"><s0>NELED5</s0>
</fA02>
<fA03 i2="1"><s0>Neurosci. lett.</s0>
</fA03>
<fA05><s2>275</s2>
</fA05>
<fA06><s2>3</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>AGUIRRE (J. A.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>CINTRA (A.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>HILLION (J.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>NARVAEZ (J. A.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>JANSSON (A.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>ANTONELLI (T.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>FERRARO (L.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>RAMBERT (F. A.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>FUXE (K.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Physiology, School of Medicine</s1>
<s2>29080, Malaga</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neuroscience, Karolinska Institutet</s1>
<s2>17177, Solna</s2>
<s3>SWE</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara</s1>
<s2>Ferrara</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Laboratoire L. Lafon</s1>
<s2>Maisons-Alfort</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>215-218</s1>
</fA20>
<fA21><s1>1999</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17240</s2>
<s5>354000080503700160</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 1999 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>17 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>99-0547776</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuroscience letters</s0>
</fA64>
<fA66 i1="01"><s0>IRL</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The effect of an acute administration of the vigilance-promoting drug modafinil ((±)(diphenyl-methyl)-sulfinyl-2 acetamide ; Modiodal) on the nigrostriatal dopamine system was studied after damage induced by MPTP (1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by means of immunohistochemistry for tyrosine hydroxylase (TH) and a stereological method. MPTP (40 mg/kg) reduced from 24 380 ± 902 to 13 501 ± 522 and from 37 868 ± 3300 to 20 568 ± 1270, respectively, the number of TH immunoreactive (IR) and non-TH IR nigral neurons. Co-administration of Modafinil restored to normal the number of these neuronal populations. MPTP treatment induced also a reduction in the volume of TH IR neurons, which was counteracted by Modafinil administration. The data provide morphological evidence, based on unbiased stereological analysis, for a potential neuroprotective role of Modafinil, not only in dopaminergic neurons, but also with a similar magnitude in the non-DA nerve cell population of the substantia nigra after MPTP lesion. These results suggest that Modafinil has a neuroprotective role in the substantia nigra via a still undefined mechanism in which a crucial role of DA uptake blockade should be excluded. Modafinil may therefore have a therapeutic potential in neurodegenerative processes such as those occurring in Parkinson's disease.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02B10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Lésion</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Lesion</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Lesión</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Locus niger</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Locus niger</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Locus níger</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Modafinil</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Modafinil</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Modafinilo</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Neuroprotecteur</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Neuroprotective agent</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Neuroprotector</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Stéréologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Stereology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Estereología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Animal model</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Modelo animal</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Mâle</s0>
<s5>54</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Male</s0>
<s5>54</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Macho</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>MPTP</s0>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>23</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>23</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>23</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>24</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>24</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>24</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Neurotransmetteur</s0>
<s5>35</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Neurotransmitter</s0>
<s5>35</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>35</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>36</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>36</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>36</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fN21><s1>355</s1>
</fN21>
</pA>
</standard>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 001C04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PascalFrancis |étape= Curation |type= RBID |clé= Pascal:99-0547776 |texte= A stereological study on the neuroprotective actions of acute Modafinil treatment on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of the male black mouse }}
This area was generated with Dilib version V0.6.29. |