ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:99-0103333

No pathogenic mutations in the persyn gene in Parkinson's disease

Identifieur interne : 003E95 ( Main/Exploration ); précédent : 003E94; suivant : 003E96

No pathogenic mutations in the persyn gene in Parkinson's disease

Auteurs : S. Lincoln [États-Unis] ; K. Gwinn-Hardy [États-Unis] ; J. Goudreau [États-Unis] ; M. C. Chartier-Harlin [France] ; M. Baker [États-Unis] ; V. Mouroux [France] ; F. Richard [France] ; A. Destee [France] ; E. Becquet [France] ; P. Amouyel [France] ; T. Lynch [Irlande (pays)] ; J. Hardy [États-Unis] ; M. Farrer [États-Unis]

Source :

Neuroscience letters [ 0304-3940 ] ; 1999.

RBID : Pascal:99-0103333

Descripteurs français

Pascal (Inist)
- Génétique, Homme, Mutation, Génétique, Parkinson maladie, Pathogénie, Parkinson maladie, Homme, Persyne, Synucléine, Synucléine β.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Genetics, Human, Mutation, Parkinson disease, Pathogenesis, Synuclein, β-Synuclein.

Abstract

The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.

Affiliations:

Le document en format XML

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<seriesStmt><title level="j" type="main">Neuroscience letters</title>
<title level="j" type="abbreviated">Neurosci. lett.</title>
<idno type="ISSN">0304-3940</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetics</term>
<term>Human</term>
<term>Mutation</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
<term>Synuclein</term>
<term>β-Synuclein</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
<term>Mutation</term>
<term>Génétique</term>
<term>Parkinson maladie</term>
<term>Pathogénie</term>
<term>Parkinson maladie</term>
<term>Homme</term>
<term>Persyne</term>
<term>Synucléine</term>
<term>Synucléine β</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The persyn (γ-synuclein) gene is highly homologous to the α-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Irlande (pays)</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
</region>
<settlement><li>Lille</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Lincoln, S" sort="Lincoln, S" uniqKey="Lincoln S" first="S." last="Lincoln">S. Lincoln</name>
</region>
<name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name>
<name sortKey="Farrer, M" sort="Farrer, M" uniqKey="Farrer M" first="M." last="Farrer">M. Farrer</name>
<name sortKey="Goudreau, J" sort="Goudreau, J" uniqKey="Goudreau J" first="J." last="Goudreau">J. Goudreau</name>
<name sortKey="Gwinn Hardy, K" sort="Gwinn Hardy, K" uniqKey="Gwinn Hardy K" first="K." last="Gwinn-Hardy">K. Gwinn-Hardy</name>
<name sortKey="Hardy, J" sort="Hardy, J" uniqKey="Hardy J" first="J." last="Hardy">J. Hardy</name>
</country>
<country name="France"><region name="Hauts-de-France"><name sortKey="Chartier Harlin, M C" sort="Chartier Harlin, M C" uniqKey="Chartier Harlin M" first="M. C." last="Chartier-Harlin">M. C. Chartier-Harlin</name>
</region>
<name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P." last="Amouyel">P. Amouyel</name>
<name sortKey="Becquet, E" sort="Becquet, E" uniqKey="Becquet E" first="E." last="Becquet">E. Becquet</name>
<name sortKey="Chartier Harlin, M C" sort="Chartier Harlin, M C" uniqKey="Chartier Harlin M" first="M. C." last="Chartier-Harlin">M. C. Chartier-Harlin</name>
<name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A." last="Destee">A. Destee</name>
<name sortKey="Mouroux, V" sort="Mouroux, V" uniqKey="Mouroux V" first="V." last="Mouroux">V. Mouroux</name>
<name sortKey="Richard, F" sort="Richard, F" uniqKey="Richard F" first="F." last="Richard">F. Richard</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Lynch, T" sort="Lynch, T" uniqKey="Lynch T" first="T." last="Lynch">T. Lynch</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

No pathogenic mutations in the persyn gene in Parkinson's disease

No pathogenic mutations in the persyn gene in Parkinson's disease

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	La maladie de Parkinson en France (serveur d'exploration)
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