Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals
Identifieur interne : 004888 ( Main/Exploration ); précédent : 004887; suivant : 004889Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals
Auteurs : F. N. Bolkenius [France] ; D. MonardSource :
- Neurochemistry international [ 0197-0186 ] ; 1995.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species. Evidence is given here that protease nexin-1 (PN-1), an endogenous thrombin inhibitor and neurite outgrowth promoter, is inactivated by xanthine oxidase-derived free radicals. Varying protection by superoxide dismutase and catalase was observed, depending on the reaction conditions. The water-soluble α-analogues-analogues MDL 74,406 (R(+ )-3,4-dihydro-6-hydroxy-N,N,N2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate), MDL 74,180DA (2,3dihydro-2,2,4,6,7-pentamethyl-3-(4-methyl-piperazino)-I-benzofuran-5-ol dihydro-chloride) and trolox also protected PN-I. Neurodegeneration may be triggered by oxidative inactivation of protease inhibitors such as PN-I. Protection of PN-1 in Alzheimer's or Parkinson's diseases, could be a possible target for a therapeutic function of antioxidants in these diseases.
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Monard</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">95-0402708</idno><date when="1995">1995</date><idno type="stanalyst">PASCAL 95-0402708 INIST</idno><idno type="RBID">Pascal:95-0402708</idno><idno type="wicri:Area/PascalFrancis/Corpus">001877</idno><idno type="wicri:Area/PascalFrancis/Curation">001770</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001724</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001724</idno><idno type="wicri:doubleKey">0197-0186:1995:Bolkenius F:inactivation:of:protease</idno><idno type="wicri:Area/Main/Merge">005205</idno><idno type="wicri:Area/Main/Curation">004888</idno><idno type="wicri:Area/Main/Exploration">004888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals</title><author><name sortKey="Bolkenius, F N" sort="Bolkenius, F N" uniqKey="Bolkenius F" first="F. N." last="Bolkenius">F. N. Bolkenius</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Marion Merrell Dow res. inst.</s1><s2>67080 Strasbourg</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Monard, D" sort="Monard, D" uniqKey="Monard D" first="D." last="Monard">D. Monard</name></author></analytic><series><title level="j" type="main">Neurochemistry international</title><title level="j" type="abbreviated">Neurochem. int.</title><idno type="ISSN">0197-0186</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurochemistry international</title><title level="j" type="abbreviated">Neurochem. int.</title><idno type="ISSN">0197-0186</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidant</term><term>Enzymatic activity</term><term>Enzyme inhibitor</term><term>Free radical</term><term>In vitro</term><term>Oxidation</term><term>Proteinases</term><term>Rat</term><term>Thrombin</term><term>Xanthine oxidase</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Proteinases</term><term>Activité enzymatique</term><term>Inhibiteur enzyme</term><term>Thrombin</term><term>Radical libre</term><term>Xanthine oxidase</term><term>Antioxydant</term><term>In vitro</term><term>Oxydation</term><term>Rat</term><term>Nexin-1</term><term>Serpin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species. Evidence is given here that protease nexin-1 (PN-1), an endogenous thrombin inhibitor and neurite outgrowth promoter, is inactivated by xanthine oxidase-derived free radicals. Varying protection by superoxide dismutase and catalase was observed, depending on the reaction conditions. The water-soluble α-analogues-analogues MDL 74,406 (R(+ )-3,4-dihydro-6-hydroxy-N,N,N2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate), MDL 74,180DA (2,3dihydro-2,2,4,6,7-pentamethyl-3-(4-methyl-piperazino)-I-benzofuran-5-ol dihydro-chloride) and trolox also protected PN-I. Neurodegeneration may be triggered by oxidative inactivation of protease inhibitors such as PN-I. Protection of PN-1 in Alzheimer's or Parkinson's diseases, could be a possible target for a therapeutic function of antioxidants in these diseases.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li></region><settlement><li>Strasbourg</li></settlement></list><tree><noCountry><name sortKey="Monard, D" sort="Monard, D" uniqKey="Monard D" first="D." last="Monard">D. Monard</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Bolkenius, F N" sort="Bolkenius, F N" uniqKey="Bolkenius F" first="F. N." last="Bolkenius">F. N. Bolkenius</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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