Autoradiographic study of [125Iepidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem
Identifieur interne : 004B98 ( Main/Exploration ); précédent : 004B97; suivant : 004B99Autoradiographic study of [125Iepidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem
Auteurs : Joao Villares [France] ; Baptiste Faucheux [France] ; Ornella Strada [France] ; Etienne C. Hirsch [France] ; Yves Agid [France] ; France Javoy-Agid [France]Source :
- Brain Research [ 0006-8993 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Autoradiography, Binding site, Brain (vertebrata), Catecholaminergic cell group, Epidermal growth factor, Epidermal growth factor receptor, Female, Human, Humans, Iodine Radioisotopes, Male, Mesencephalon (chemistry), Parkinson Disease (metabolism), Parkinson disease, Parkinson's disease, Postmortem, Postmortem Changes, Radioligand Assay, Receptor, Epidermal Growth Factor (analysis).
- MESH :
- chemical , analysis : Receptor, Epidermal Growth Factor.
- chemical : Iodine Radioisotopes.
- chemistry : Mesencephalon.
- metabolism : Parkinson Disease.
- Autoradiography, Female, Humans, Male, Postmortem Changes, Radioligand Assay.
Abstract
Abstract: Epidermal growth factor (EGF) is assumed to act as a neurotrophic factor on dopaminergic nigrostriatal neurons in cell cultures and animal brain. This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125IEGF-binding sites were similar in controls and parkinsonian patients. This suggests that EGF receptors in the mesencephalon are unaffected in Parkinson's disease and may therefore contribute to the increased activity and survival of the remaining dopaminergic neurons.
Url:
DOI: 10.1016/0006-8993(93)90939-K
Affiliations:
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This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125IEGF-binding sites were similar in controls and parkinsonian patients. This suggests that EGF receptors in the mesencephalon are unaffected in Parkinson's disease and may therefore contribute to the increased activity and survival of the remaining dopaminergic neurons.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Villares, Joao" sort="Villares, Joao" uniqKey="Villares J" first="Joao" last="Villares">Joao Villares</name></region><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Faucheux, Baptiste" sort="Faucheux, Baptiste" uniqKey="Faucheux B" first="Baptiste" last="Faucheux">Baptiste Faucheux</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Javoy Agid, France" sort="Javoy Agid, France" uniqKey="Javoy Agid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><name sortKey="Strada, Ornella" sort="Strada, Ornella" uniqKey="Strada O" first="Ornella" last="Strada">Ornella Strada</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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