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La maladie de Parkinson en France (serveur d'exploration)

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Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem

Identifieur interne : 001A01 ( PascalFrancis/Corpus ); précédent : 001A00; suivant : 001A02

Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem

Auteurs : J. Villares ; B. Faucheux ; O. Strada ; E. C. Hirsch ; Y. Agid ; F. Javoy-Agid

Source :

RBID : Pascal:94-0039283

Descripteurs français

English descriptors

Abstract

Epidermal growth factor (EGF) is assumed to act as a neurotrophic factor on dopaminergic nigrostriatal neurons in cell cultures and animal brain. This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125I]EGF-binding sites were similar in controls and parkinsonian patients

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0006-8993
A02 01      @0 BRREAP
A03   1    @0 Brain res.
A05       @2 628
A06       @2 1-2
A08 01  1  ENG  @1 Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem
A11 01  1    @1 VILLARES (J.)
A11 02  1    @1 FAUCHEUX (B.)
A11 03  1    @1 STRADA (O.)
A11 04  1    @1 HIRSCH (E. C.)
A11 05  1    @1 AGID (Y.)
A11 06  1    @1 JAVOY-AGID (F.)
A14 01      @1 INSERM, U289 lab. médecine exp. @2 75013 Paris @3 FRA
A14 02      @1 Association Claude Bernard, cent. gérontologie @2 Paris @3 FRA @Z 2 aut.
A20       @1 72-76
A21       @1 1993
A23 01      @0 ENG
A43 01      @1 INIST @2 12895 @5 354000026323480100
A44       @0 0000
A45       @0 23 ref.
A47 01  1    @0 94-0039283
A60       @1 P
A61       @0 A
A64 01  1    @0 Brain research
A66 01      @0 NLD
C01 01    ENG  @0 Epidermal growth factor (EGF) is assumed to act as a neurotrophic factor on dopaminergic nigrostriatal neurons in cell cultures and animal brain. This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125I]EGF-binding sites were similar in controls and parkinsonian patients
C02 01  X    @0 002B17G
C03 01  X  FRE  @0 Autoradiographie @5 01
C03 01  X  ENG  @0 Autoradiography @5 01
C03 01  X  GER  @0 Autoradiographie @5 01
C03 01  X  SPA  @0 Autorradiografía @5 01
C03 02  X  FRE  @0 Facteur croissance épiderme @5 02
C03 02  X  ENG  @0 Epidermal growth factor @5 02
C03 02  X  SPA  @0 Factor crecimiento epidermi @5 02
C03 03  X  FRE  @0 Site fixation @5 03
C03 03  X  ENG  @0 Binding site @5 03
C03 03  X  SPA  @0 Sitio fijación @5 03
C03 04  X  FRE  @0 Parkinson maladie @2 NM @5 04
C03 04  X  ENG  @0 Parkinson disease @2 NM @5 04
C03 04  X  SPA  @0 Parkinson enfermedad @2 NM @5 04
C03 05  X  FRE  @0 Encéphale @5 05
C03 05  X  ENG  @0 Brain (vertebrata) @5 05
C03 05  X  SPA  @0 Encéfalo @5 05
C03 06  X  FRE  @0 Postmortem @5 07
C03 06  X  ENG  @0 Postmortem @5 07
C03 06  X  SPA  @0 Postmortem @5 07
C03 07  X  FRE  @0 Homme @5 54
C03 07  X  ENG  @0 Human @5 54
C03 07  X  SPA  @0 Hombre @5 54
C07 01  X  FRE  @0 Maladie dégénérative @5 26
C07 01  X  ENG  @0 Degenerative disease @5 26
C07 01  X  SPA  @0 Enfermedad degenerativa @5 26
C07 02  X  FRE  @0 Système nerveux pathologie @5 27
C07 02  X  ENG  @0 Nervous system diseases @5 27
C07 02  X  SPA  @0 Sistema nervioso patología @5 27
C07 03  X  FRE  @0 Système nerveux central @5 29
C07 03  X  ENG  @0 Central nervous system @5 29
C07 03  X  SPA  @0 Sistema nervioso central @5 29
N21       @1 011

Format Inist (serveur)

NO : PASCAL 94-0039283 INIST
ET : Autoradiographic study of [125I]epidermal growth factor-binding sites in the mesencephalon of control and parkinsonian brains post-mortem
AU : VILLARES (J.); FAUCHEUX (B.); STRADA (O.); HIRSCH (E. C.); AGID (Y.); JAVOY-AGID (F.)
AF : INSERM, U289 lab. médecine exp./75013 Paris/France; Association Claude Bernard, cent. gérontologie/Paris/France (2 aut.)
DT : Publication en série; Niveau analytique
SO : Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1993; Vol. 628; No. 1-2; Pp. 72-76; Bibl. 23 ref.
LA : Anglais
EA : Epidermal growth factor (EGF) is assumed to act as a neurotrophic factor on dopaminergic nigrostriatal neurons in cell cultures and animal brain. This led us to consider its possible role in the pathophysiology of Parkinson's disease. An autoradiographic study of the distribution of EGF-binding sites was performed in the mesencephalon of controls and patients with Parkinson's disease, a neurodegenerative disease associated with dramatic damage to the mesostriatal dopaminergic neurons. Scatchard analysis revealed a single type of binding sites with a high affinity constant, in the various mesencephalic dopaminergic areas examined. The characteristics and density of [125I]EGF-binding sites were similar in controls and parkinsonian patients
CC : 002B17G
FD : Autoradiographie; Facteur croissance épiderme; Site fixation; Parkinson maladie; Encéphale; Postmortem; Homme
FG : Maladie dégénérative; Système nerveux pathologie; Système nerveux central
ED : Autoradiography; Epidermal growth factor; Binding site; Parkinson disease; Brain (vertebrata); Postmortem; Human
EG : Degenerative disease; Nervous system diseases; Central nervous system
GD : Autoradiographie
SD : Autorradiografía; Factor crecimiento epidermi; Sitio fijación; Parkinson enfermedad; Encéfalo; Postmortem; Hombre
LO : INIST-12895.354000026323480100
ID : 94-0039283

Links to Exploration step

Pascal:94-0039283

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