Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?. Commentary
Identifieur interne : 002D79 ( Main/Exploration ); précédent : 002D78; suivant : 002D80Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?. Commentary
Auteurs : M. Samuel [Royaume-Uni] ; V. Voon [États-Unis] ; V. Czernecki [France] ; B. Pillon [France] ; J. L. Houeto [France] ; M. L. Welter [France] ; V. Mesnage [France] ; Yves Agid [France] ; B. Dubois [France]Source :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: High frequency stimulation of the subthalamic nucleus (STN) dramatically decreases motor disability in patients with Parkinson"s disease (PD), but has been reported to aggravate apathy. The aim of this study was to analyse the effect of STN stimulation on motivation and reward sensitivity in a consecutive series of PD patients. Methods: Apathy and reward sensitivity (Apathy Scale, Stimulus-Reward Learning, Reversal, Extinction, and Gambling tasks) were assessed in 18 PD patients treated by bilateral STN stimulation ("on" and "off" conditions) compared with 23 matched patients undergoing long term treatment with levodopa ("on" and "off" conditions). Results: Apathy decreased under both STN stimulation and levodopa treatment, whereas explicit and implicit stimulus reward learning was unchanged. Conclusions: Bilateral STN stimulation in PD patients does not necessarily have a negative effect on motivation and reward sensitivity and can even improve apathy provided patients have been appropriately selected for neurosurgery.
Affiliations:
- France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Maryland, Île-de-France
- Londres, Paris
- Hôpital de la Salpêtrière
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Commentary</title><author><name sortKey="Samuel, M" sort="Samuel, M" uniqKey="Samuel M" first="M." last="Samuel">M. Samuel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, King's College Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Voon, V" sort="Voon, V" uniqKey="Voon V" first="V." last="Voon">V. Voon</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Institutes of Neurological Disorders and Stroke, National Institute of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V." last="Czernecki">V. Czernecki</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U 610, Pavillon Claude Bernard, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B." last="Pillon">B. Pillon</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U 610, Pavillon Claude Bernard, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M. L." last="Welter">M. L. Welter</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V." last="Mesnage">V. Mesnage</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U 610, Pavillon Claude Bernard, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Noyau sousthalamique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: High frequency stimulation of the subthalamic nucleus (STN) dramatically decreases motor disability in patients with Parkinson"s disease (PD), but has been reported to aggravate apathy. The aim of this study was to analyse the effect of STN stimulation on motivation and reward sensitivity in a consecutive series of PD patients. Methods: Apathy and reward sensitivity (Apathy Scale, Stimulus-Reward Learning, Reversal, Extinction, and Gambling tasks) were assessed in 18 PD patients treated by bilateral STN stimulation ("on" and "off" conditions) compared with 23 matched patients undergoing long term treatment with levodopa ("on" and "off" conditions). Results: Apathy decreased under both STN stimulation and levodopa treatment, whereas explicit and implicit stimulus reward learning was unchanged. Conclusions: Bilateral STN stimulation in PD patients does not necessarily have a negative effect on motivation and reward sensitivity and can even improve apathy provided patients have been appropriately selected for neurosurgery.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Samuel, M" sort="Samuel, M" uniqKey="Samuel M" first="M." last="Samuel">M. Samuel</name></region></country><country name="États-Unis"><region name="Maryland"><name sortKey="Voon, V" sort="Voon, V" uniqKey="Voon V" first="V." last="Voon">V. Voon</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V." last="Czernecki">V. Czernecki</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V." last="Mesnage">V. Mesnage</name><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B." last="Pillon">B. Pillon</name><name sortKey="Pillon, B" sort="Pillon, B" uniqKey="Pillon B" first="B." last="Pillon">B. Pillon</name><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M. L." last="Welter">M. L. 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