ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:05-0193219

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

Identifieur interne : 002D46 ( Main/Exploration ); précédent : 002D45; suivant : 002D47

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

Auteurs : Isabelle Arnulf [France] ; Milagros Merino-Andreu [France] ; Frédéric Bloch [France] ; Eric Konofal [France] ; Marie Vidailhet [France] ; Valérie Cochen [France] ; Jean-Philippe Derenne [France] ; Yves Agid [France]

Source :

Sleep : (New York, NY) [ 0161-8105 ] ; 2005.

RBID : Pascal:05-0193219

Descripteurs français

Pascal (Inist)
- Paralysie susnucléaire, Etude comparative, Individu sain, Parkinson maladie, Sommeil paradoxal, Polysomnographie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Comparative study, Electroencephalography, Female, Healthy subject, Human, Humans, Male, Muscle Hypotonia, Muscle, Skeletal (physiology), Parkinson Disease (epidemiology), Parkinson disease, Polysomnography, REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (epidemiology), REM Sleep Behavior Disorder (physiopathology), Rapid eye movement sleep, Severity of Illness Index, Supranuclear Palsy, Progressive (epidemiology), Supranuclear paralysis.
MESH :
- diagnosis : REM Sleep Behavior Disorder.
- epidemiology : Parkinson Disease, REM Sleep Behavior Disorder, Supranuclear Palsy, Progressive.
- physiology : Muscle, Skeletal.
- physiopathology : REM Sleep Behavior Disorder.
- Aged, Electroencephalography, Female, Humans, Male, Muscle Hypotonia, Polysomnography, Severity of Illness Index.

Abstract

Study Objective: To compare sleep characteristics, rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects. Design: Sleep interview, overnight polysomnography, and Multiple Sleep Latency Tests. Patients: Forty-five age- and sex-matched patients with probable progressive supranuclear palsy, (n = 15, aged 68 ± 8 years, 7 men), patients with Parkinson disease (n = 15), and control subjects (n = 15). Settings: Tertiary-care academic hospital. Intervention: N/A. Results: Compared to the 2 other groups, patients with progressive supranuclear palsy had a longer duration of wakefulness after sleep onset and twice as much sleep fragmentation and percentage of stage 1 sleep but had similar apnea-hypopnea indexes, periodic leg movements indexes, and mean daytime sleep latencies. REM sleep percentage was as low in patients with progressive supranuclear palsy (8% ± 6% of total sleep time) as in patients with Parkinson disease (10% ± 4%), versus 20% ± 6% in controls (analysis of variance, P <.0001). Interestingly, patients with progressive supranuclear palsy had percentages of REM sleep without atonia (chin muscle activity: 33% ± 36% of REM sleep) similar to those of patients with Parkinson disease (28% ± 35%) and dramatically higher than those of controls (0.5% ± 1%, analysis of variance, P =.008). Four (27%) patients with progressive supranuclear palsy had more than 50% REM sleep without atonia (as did a similar number of patients with Parkinson disease), and 2 of them (13%, vs 20% of patients with Parkinson disease) had clinical RBD. The four patients with progressive supranuclear palsy with excessive daytime sleepiness slept longer at night than the 11 patients with progressive supranuclear palsy who were alert (442 ± 14 minutes vs 312 ± 74 minutes, student t tests, P =.004), suggesting a primary nonnarcoleptic hypersomnia. Conclusion: REM sleep without atonia and RBD were as frequent in patients with progressive supranuclear palsy as in patients with Parkinson disease. It suggests that the downstream cause of parkinsonism, rather than its primary neuropathology (synucleinopathy vs tauopathy), is a key factor for REM sleep behavior disorder.

Affiliations:

Le document en format XML

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<term>Comparative study</term>
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<front><div type="abstract" xml:lang="en">Study Objective: To compare sleep characteristics, rapid eye movement (REM) sleep without atonia, and REM sleep behavior disorder (RBD) in patients with progressive supranuclear palsy (tauopathy), patients with Parkinson's disease (a synucleinopathy), and control subjects. Design: Sleep interview, overnight polysomnography, and Multiple Sleep Latency Tests. Patients: Forty-five age- and sex-matched patients with probable progressive supranuclear palsy, (n = 15, aged 68 ± 8 years, 7 men), patients with Parkinson disease (n = 15), and control subjects (n = 15). Settings: Tertiary-care academic hospital. Intervention: N/A. Results: Compared to the 2 other groups, patients with progressive supranuclear palsy had a longer duration of wakefulness after sleep onset and twice as much sleep fragmentation and percentage of stage 1 sleep but had similar apnea-hypopnea indexes, periodic leg movements indexes, and mean daytime sleep latencies. REM sleep percentage was as low in patients with progressive supranuclear palsy (8% ± 6% of total sleep time) as in patients with Parkinson disease (10% ± 4%), versus 20% ± 6% in controls (analysis of variance, P <.0001). Interestingly, patients with progressive supranuclear palsy had percentages of REM sleep without atonia (chin muscle activity: 33% ± 36% of REM sleep) similar to those of patients with Parkinson disease (28% ± 35%) and dramatically higher than those of controls (0.5% ± 1%, analysis of variance, P =.008). Four (27%) patients with progressive supranuclear palsy had more than 50% REM sleep without atonia (as did a similar number of patients with Parkinson disease), and 2 of them (13%, vs 20% of patients with Parkinson disease) had clinical RBD. The four patients with progressive supranuclear palsy with excessive daytime sleepiness slept longer at night than the 11 patients with progressive supranuclear palsy who were alert (442 ± 14 minutes vs 312 ± 74 minutes, student t tests, P =.004), suggesting a primary nonnarcoleptic hypersomnia. Conclusion: REM sleep without atonia and RBD were as frequent in patients with progressive supranuclear palsy as in patients with Parkinson disease. It suggests that the downstream cause of parkinsonism, rather than its primary neuropathology (synucleinopathy vs tauopathy), is a key factor for REM sleep behavior disorder.</div>
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<name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name>
<name sortKey="Cochen, Valerie" sort="Cochen, Valerie" uniqKey="Cochen V" first="Valérie" last="Cochen">Valérie Cochen</name>
<name sortKey="Derenne, Jean Philippe" sort="Derenne, Jean Philippe" uniqKey="Derenne J" first="Jean-Philippe" last="Derenne">Jean-Philippe Derenne</name>
<name sortKey="Konofal, Eric" sort="Konofal, Eric" uniqKey="Konofal E" first="Eric" last="Konofal">Eric Konofal</name>
<name sortKey="Merino Andreu, Milagros" sort="Merino Andreu, Milagros" uniqKey="Merino Andreu M" first="Milagros" last="Merino-Andreu">Milagros Merino-Andreu</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D46 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:05-0193219
   |texte=   REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

La maladie de Parkinson en France (serveur d'exploration)

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

REM Sleep behavior disorder and REM Sleep without atonia in patients with progressive supranuclear palsy

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.