ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:04-0194484

Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus

Identifieur interne : 003029 ( Main/Exploration ); précédent : 003028; suivant : 003030

Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus

Auteurs : N. Hamaue [Japon] ; M. Minami [Japon] ; M. Terado [Japon] ; M. Hirafuji [Japon] ; T. Endo [Japon] ; M. Machida [Japon] ; T. Hiroshige [Japon] ; A. Ogata [Japon] ; K. Tashiro [Japon] ; H. Saito [Japon] ; S. H. Parvez [France]

Source :

Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2004.

RBID : Pascal:04-0194484

Descripteurs français

Pascal (Inist)
- Etude comparative, IMAO B, Amine oxidase (flavin-containing), Endogène, Inhibiteur enzyme, Catécholamine, Sélégiline, Stimulant dopaminergique, Parkinson maladie, Dopamine, Modèle animal, Encéphalite japonaise, Rat, Virus, Neurologie, Toxicologie.
Wicri :
- topic : Neurologie, Toxicologie.

English descriptors

KwdEn :
- Amine oxidase (flavin-containing), Animal model, Catecholamine, Comparative study, Dopamine, Dopamine agonist, Endogenous, Enzyme inhibitor, Japanese encephalitis, MAO B inhibitor, Neurology, Parkinson disease, Rat, Selegiline, Toxicology, Virus.

Abstract

We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000E40
to stream PascalFrancis, to step Curation: 000594
to stream PascalFrancis, to step Checkpoint: 000C60
to stream Main, to step Merge: 003460
to stream Main, to step Curation: 003029

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus</title>
<author><name sortKey="Hamaue, N" sort="Hamaue, N" uniqKey="Hamaue N" first="N." last="Hamaue">N. Hamaue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Minami, M" sort="Minami, M" uniqKey="Minami M" first="M." last="Minami">M. Minami</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Terado, M" sort="Terado, M" uniqKey="Terado M" first="M." last="Terado">M. Terado</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hirafuji, M" sort="Hirafuji, M" uniqKey="Hirafuji M" first="M." last="Hirafuji">M. Hirafuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Endo, T" sort="Endo, T" uniqKey="Endo T" first="T." last="Endo">T. Endo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Machida, M" sort="Machida, M" uniqKey="Machida M" first="M." last="Machida">M. Machida</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hiroshige, T" sort="Hiroshige, T" uniqKey="Hiroshige T" first="T." last="Hiroshige">T. Hiroshige</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ogata, A" sort="Ogata, A" uniqKey="Ogata A" first="A." last="Ogata">A. Ogata</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hokkaido University School of Medicine</s1>
<s2>060-8638 Sapporo</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>060-8638 Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tashiro, K" sort="Tashiro, K" uniqKey="Tashiro K" first="K." last="Tashiro">K. Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hokkaido University School of Medicine</s1>
<s2>060-8638 Sapporo</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>060-8638 Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saito, H" sort="Saito, H" uniqKey="Saito H" first="H." last="Saito">H. Saito</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Basic Sciences, Red-Cross Nursing College of Hokkaido</s1>
<s2>090-0011 Kitami, Hokkaido</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>090-0011 Kitami, Hokkaido</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Neuroendocrinology and Neuropharmacology, CNRS, Institute Alfred-Fessard-Bât 5</s1>
<s2>91190 Gif Sur Yvette</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Gif Sur Yvette</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">04-0194484</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 04-0194484 INIST</idno>
<idno type="RBID">Pascal:04-0194484</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000E40</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000594</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000C60</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000C60</idno>
<idno type="wicri:doubleKey">0161-813X:2004:Hamaue N:comparative:study:of</idno>
<idno type="wicri:Area/Main/Merge">003460</idno>
<idno type="wicri:Area/Main/Curation">003029</idno>
<idno type="wicri:Area/Main/Exploration">003029</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus</title>
<author><name sortKey="Hamaue, N" sort="Hamaue, N" uniqKey="Hamaue N" first="N." last="Hamaue">N. Hamaue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Minami, M" sort="Minami, M" uniqKey="Minami M" first="M." last="Minami">M. Minami</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Terado, M" sort="Terado, M" uniqKey="Terado M" first="M." last="Terado">M. Terado</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hirafuji, M" sort="Hirafuji, M" uniqKey="Hirafuji M" first="M." last="Hirafuji">M. Hirafuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Endo, T" sort="Endo, T" uniqKey="Endo T" first="T." last="Endo">T. Endo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Machida, M" sort="Machida, M" uniqKey="Machida M" first="M." last="Machida">M. Machida</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hiroshige, T" sort="Hiroshige, T" uniqKey="Hiroshige T" first="T." last="Hiroshige">T. Hiroshige</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>061-0293 Ishikari-Tobetsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ogata, A" sort="Ogata, A" uniqKey="Ogata A" first="A." last="Ogata">A. Ogata</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hokkaido University School of Medicine</s1>
<s2>060-8638 Sapporo</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>060-8638 Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tashiro, K" sort="Tashiro, K" uniqKey="Tashiro K" first="K." last="Tashiro">K. Tashiro</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Hokkaido University School of Medicine</s1>
<s2>060-8638 Sapporo</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>060-8638 Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saito, H" sort="Saito, H" uniqKey="Saito H" first="H." last="Saito">H. Saito</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Basic Sciences, Red-Cross Nursing College of Hokkaido</s1>
<s2>090-0011 Kitami, Hokkaido</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>090-0011 Kitami, Hokkaido</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Neuroendocrinology and Neuropharmacology, CNRS, Institute Alfred-Fessard-Bât 5</s1>
<s2>91190 Gif Sur Yvette</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Gif Sur Yvette</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title>
<title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title>
<idno type="ISSN">0161-813X</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurotoxicology : (Park Forest South)</title>
<title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title>
<idno type="ISSN">0161-813X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amine oxidase (flavin-containing)</term>
<term>Animal model</term>
<term>Catecholamine</term>
<term>Comparative study</term>
<term>Dopamine</term>
<term>Dopamine agonist</term>
<term>Endogenous</term>
<term>Enzyme inhibitor</term>
<term>Japanese encephalitis</term>
<term>MAO B inhibitor</term>
<term>Neurology</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Selegiline</term>
<term>Toxicology</term>
<term>Virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etude comparative</term>
<term>IMAO B</term>
<term>Amine oxidase (flavin-containing)</term>
<term>Endogène</term>
<term>Inhibiteur enzyme</term>
<term>Catécholamine</term>
<term>Sélégiline</term>
<term>Stimulant dopaminergique</term>
<term>Parkinson maladie</term>
<term>Dopamine</term>
<term>Modèle animal</term>
<term>Encéphalite japonaise</term>
<term>Rat</term>
<term>Virus</term>
<term>Neurologie</term>
<term>Toxicologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Neurologie</term>
<term>Toxicologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Japon</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Gif Sur Yvette</li>
</settlement>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Hamaue, N" sort="Hamaue, N" uniqKey="Hamaue N" first="N." last="Hamaue">N. Hamaue</name>
</noRegion>
<name sortKey="Endo, T" sort="Endo, T" uniqKey="Endo T" first="T." last="Endo">T. Endo</name>
<name sortKey="Hirafuji, M" sort="Hirafuji, M" uniqKey="Hirafuji M" first="M." last="Hirafuji">M. Hirafuji</name>
<name sortKey="Hiroshige, T" sort="Hiroshige, T" uniqKey="Hiroshige T" first="T." last="Hiroshige">T. Hiroshige</name>
<name sortKey="Machida, M" sort="Machida, M" uniqKey="Machida M" first="M." last="Machida">M. Machida</name>
<name sortKey="Minami, M" sort="Minami, M" uniqKey="Minami M" first="M." last="Minami">M. Minami</name>
<name sortKey="Ogata, A" sort="Ogata, A" uniqKey="Ogata A" first="A." last="Ogata">A. Ogata</name>
<name sortKey="Saito, H" sort="Saito, H" uniqKey="Saito H" first="H." last="Saito">H. Saito</name>
<name sortKey="Tashiro, K" sort="Tashiro, K" uniqKey="Tashiro K" first="K." last="Tashiro">K. Tashiro</name>
<name sortKey="Terado, M" sort="Terado, M" uniqKey="Terado M" first="M." last="Terado">M. Terado</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003029 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003029 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:04-0194484
   |texte=   Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus

Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri