Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
Identifieur interne : 000E40 ( PascalFrancis/Corpus ); précédent : 000E39; suivant : 000E41Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
Auteurs : N. Hamaue ; M. Minami ; M. Terado ; M. Hirafuji ; T. Endo ; M. Machida ; T. Hiroshige ; A. Ogata ; K. Tashiro ; H. Saito ; S. H. ParvezSource :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.
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Format Inist (serveur)
NO : | PASCAL 04-0194484 INIST |
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ET : | Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus |
AU : | HAMAUE (N.); MINAMI (M.); TERADO (M.); HIRAFUJI (M.); ENDO (T.); MACHIDA (M.); HIROSHIGE (T.); OGATA (A.); TASHIRO (K.); SAITO (H.); PARVEZ (S. H.); NICOTRA (A.); PARVEZ (S. H.); GLOVER (V.); SANDLER (M.); PARVEZ (S.); MINAMI (M.) |
AF : | The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Department of Neurology, Hokkaido University School of Medicine/060-8638 Sapporo/Japon (8 aut., 9 aut.); Department of Basic Sciences, Red-Cross Nursing College of Hokkaido/090-0011 Kitami, Hokkaido/Japon (10 aut.); Neuroendocrinology and Neuropharmacology, CNRS, Institute Alfred-Fessard-Bât 5/91190 Gif Sur Yvette/France (11 aut.); Dept. Animal and Human Biology, University of Rome I, Viale dell'Università 32/00198 Rome/Italie (1 aut.); Institut Alfred Fressard of Neuroscience, Bât5 Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut., 5 aut.); Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road/London, W12 ONN/Royaume-Uni (3 aut., 4 aut.); The Research Institute of Personalized Health, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Neurotoxicology : (Park Forest South); ISSN 0161-813X; Etats-Unis; Da. 2004; Vol. 25; No. 1-2; Pp. 205-213; Bibl. 35 ref. |
LA : | Anglais |
EA : | We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum. |
CC : | 002A25; 002B03; 002B17 |
FD : | Etude comparative; IMAO B; Amine oxidase (flavin-containing); Endogène; Inhibiteur enzyme; Catécholamine; Sélégiline; Stimulant dopaminergique; Parkinson maladie; Dopamine; Modèle animal; Encéphalite japonaise; Rat; Virus; Neurologie; Toxicologie |
FG : | Oxidoreductases; Enzyme; Arbovirose; Virose; Infection; Rodentia; Mammalia; Vertebrata; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie |
ED : | Comparative study; MAO B inhibitor; Amine oxidase (flavin-containing); Endogenous; Enzyme inhibitor; Catecholamine; Selegiline; Dopamine agonist; Parkinson disease; Dopamine; Animal model; Japanese encephalitis; Rat; Virus; Neurology; Toxicology |
EG : | Oxidoreductases; Enzyme; Arbovirus disease; Viral disease; Infection; Rodentia; Mammalia; Vertebrata; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases |
SD : | Estudio comparativo; IMOA B; Amine oxidase (flavin-containing); Endógeno; Inhibidor enzima; Catecolamina; Selegilina; Estimulante dopaminérgico; Parkinson enfermedad; Dopamina; Modelo animal; Encefalitis japonesa; Rata; Virus; Neurología; Toxicología |
LO : | INIST-18397.354000119285470210 |
ID : | 04-0194484 |
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Pascal:04-0194484Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus</title>
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<series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title>
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<term>Animal model</term>
<term>Catecholamine</term>
<term>Comparative study</term>
<term>Dopamine</term>
<term>Dopamine agonist</term>
<term>Endogenous</term>
<term>Enzyme inhibitor</term>
<term>Japanese encephalitis</term>
<term>MAO B inhibitor</term>
<term>Neurology</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Selegiline</term>
<term>Toxicology</term>
<term>Virus</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Etude comparative</term>
<term>IMAO B</term>
<term>Amine oxidase (flavin-containing)</term>
<term>Endogène</term>
<term>Inhibiteur enzyme</term>
<term>Catécholamine</term>
<term>Sélégiline</term>
<term>Stimulant dopaminergique</term>
<term>Parkinson maladie</term>
<term>Dopamine</term>
<term>Modèle animal</term>
<term>Encéphalite japonaise</term>
<term>Rat</term>
<term>Virus</term>
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<front><div type="abstract" xml:lang="en">We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus</s1>
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<fA09 i1="01" i2="1" l="ENG"><s1>Monoamine Oxidases: Molecular, Pharmacological and Neurotoxicological Aspects. A Tribute to Prof. Merton Sandler</s1>
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<fA11 i1="08" i2="1"><s1>OGATA (A.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>TASHIRO (K.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>SAITO (H.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>PARVEZ (S. H.)</s1>
</fA11>
<fA12 i1="01" i2="1"><s1>NICOTRA (A.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="02" i2="1"><s1>PARVEZ (S. H.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="03" i2="1"><s1>GLOVER (V.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="04" i2="1"><s1>SANDLER (M.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="05" i2="1"><s1>PARVEZ (S.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="06" i2="1"><s1>MINAMI (M.)</s1>
<s9>ed.</s9>
</fA12>
<fA14 i1="01"><s1>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neurology, Hokkaido University School of Medicine</s1>
<s2>060-8638 Sapporo</s2>
<s3>JPN</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Basic Sciences, Red-Cross Nursing College of Hokkaido</s1>
<s2>090-0011 Kitami, Hokkaido</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Neuroendocrinology and Neuropharmacology, CNRS, Institute Alfred-Fessard-Bât 5</s1>
<s2>91190 Gif Sur Yvette</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA15 i1="01"><s1>Dept. Animal and Human Biology, University of Rome I, Viale dell'Università 32</s1>
<s2>00198 Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
</fA15>
<fA15 i1="02"><s1>Institut Alfred Fressard of Neuroscience, Bât5 Parc Chateau, CNRS</s1>
<s2>91190 Gif sur Yvette</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</fA15>
<fA15 i1="03"><s1>Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road</s1>
<s2>London, W12 ONN</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA15>
<fA15 i1="04"><s1>The Research Institute of Personalized Health, Health Sciences University of Hokkaido</s1>
<s2>061-0293 Ishikari-Tobetsu</s2>
<s3>JPN</s3>
<sZ>6 aut.</sZ>
</fA15>
<fA20><s1>205-213</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>18397</s2>
<s5>354000119285470210</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>35 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0194484</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neurotoxicology : (Park Forest South)</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B03</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>IMAO B</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>MAO B inhibitor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>IMOA B</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Amine oxidase (flavin-containing)</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Amine oxidase (flavin-containing)</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Amine oxidase (flavin-containing)</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Endogène</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Endogenous</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Endógeno</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Sélégiline</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Selegiline</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Selegilina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Stimulant dopaminergique</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Dopamine agonist</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Estimulante dopaminérgico</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Animal model</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Modelo animal</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Encéphalite japonaise</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Japanese encephalitis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Encefalitis japonesa</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Rat</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Rat</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Rata</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
<s5>15</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Neurologie</s0>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Neurology</s0>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Neurología</s0>
<s5>16</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Toxicologie</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Toxicology</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Toxicología</s0>
<s5>17</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Arbovirose</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Arbovirus disease</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Arbovirosis</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>61</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>61</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>61</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>62</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>62</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>62</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>63</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>63</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>63</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>64</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>64</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>64</s5>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>65</s5>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>65</s5>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>65</s5>
</fC07>
<fN21><s1>131</s1>
</fN21>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 04-0194484 INIST</NO>
<ET>Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus</ET>
<AU>HAMAUE (N.); MINAMI (M.); TERADO (M.); HIRAFUJI (M.); ENDO (T.); MACHIDA (M.); HIROSHIGE (T.); OGATA (A.); TASHIRO (K.); SAITO (H.); PARVEZ (S. H.); NICOTRA (A.); PARVEZ (S. H.); GLOVER (V.); SANDLER (M.); PARVEZ (S.); MINAMI (M.)</AU>
<AF>The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); Department of Neurology, Hokkaido University School of Medicine/060-8638 Sapporo/Japon (8 aut., 9 aut.); Department of Basic Sciences, Red-Cross Nursing College of Hokkaido/090-0011 Kitami, Hokkaido/Japon (10 aut.); Neuroendocrinology and Neuropharmacology, CNRS, Institute Alfred-Fessard-Bât 5/91190 Gif Sur Yvette/France (11 aut.); Dept. Animal and Human Biology, University of Rome I, Viale dell'Università 32/00198 Rome/Italie (1 aut.); Institut Alfred Fressard of Neuroscience, Bât5 Parc Chateau, CNRS/91190 Gif sur Yvette/France (2 aut., 5 aut.); Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road/London, W12 ONN/Royaume-Uni (3 aut., 4 aut.); The Research Institute of Personalized Health, Health Sciences University of Hokkaido/061-0293 Ishikari-Tobetsu/Japon (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neurotoxicology : (Park Forest South); ISSN 0161-813X; Etats-Unis; Da. 2004; Vol. 25; No. 1-2; Pp. 205-213; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.</EA>
<CC>002A25; 002B03; 002B17</CC>
<FD>Etude comparative; IMAO B; Amine oxidase (flavin-containing); Endogène; Inhibiteur enzyme; Catécholamine; Sélégiline; Stimulant dopaminergique; Parkinson maladie; Dopamine; Modèle animal; Encéphalite japonaise; Rat; Virus; Neurologie; Toxicologie</FD>
<FG>Oxidoreductases; Enzyme; Arbovirose; Virose; Infection; Rodentia; Mammalia; Vertebrata; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie</FG>
<ED>Comparative study; MAO B inhibitor; Amine oxidase (flavin-containing); Endogenous; Enzyme inhibitor; Catecholamine; Selegiline; Dopamine agonist; Parkinson disease; Dopamine; Animal model; Japanese encephalitis; Rat; Virus; Neurology; Toxicology</ED>
<EG>Oxidoreductases; Enzyme; Arbovirus disease; Viral disease; Infection; Rodentia; Mammalia; Vertebrata; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases</EG>
<SD>Estudio comparativo; IMOA B; Amine oxidase (flavin-containing); Endógeno; Inhibidor enzima; Catecolamina; Selegilina; Estimulante dopaminérgico; Parkinson enfermedad; Dopamina; Modelo animal; Encefalitis japonesa; Rata; Virus; Neurología; Toxicología</SD>
<LO>INIST-18397.354000119285470210</LO>
<ID>04-0194484</ID>
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