Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
Identifieur interne : 000917 ( Main/Exploration ); précédent : 000916; suivant : 000918Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
Auteurs : Kristina Ibá Ez [Espagne] ; César Boullosa [Espagne] ; Rafael Tabarés-Seisdedos [Espagne] ; Anaïs Baudot [France] ; Alfonso Valencia [Espagne]Source :
- PLoS Genetics [ 1553-7390 ] ; 2014.
English descriptors
- KwdEn :
- Alzheimer Disease (epidemiology), Alzheimer Disease (genetics), Alzheimer Disease (pathology), Central Nervous System (pathology), Comorbidity, Gene Expression Profiling, Gene Expression Regulation, Humans, NIMA-Interacting Peptidylprolyl Isomerase, Neoplasms (epidemiology), Neoplasms (genetics), Neoplasms (pathology), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Peptidylprolyl Isomerase (genetics), Schizophrenia (epidemiology), Schizophrenia (genetics), Schizophrenia (pathology), Signal Transduction.
- MESH :
- chemical , genetics : Peptidylprolyl Isomerase.
- chemical : NIMA-Interacting Peptidylprolyl Isomerase.
- epidemiology : Alzheimer Disease, Neoplasms, Parkinson Disease, Schizophrenia.
- genetics : Alzheimer Disease, Neoplasms, Parkinson Disease, Schizophrenia.
- pathology : Alzheimer Disease, Central Nervous System, Neoplasms, Parkinson Disease, Schizophrenia.
- Comorbidity, Gene Expression Profiling, Gene Expression Regulation, Humans, Signal Transduction.
Abstract
There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this
Url:
DOI: 10.1371/journal.pgen.1004173
PubMed: 24586201
PubMed Central: 3930576
Affiliations:
- Espagne, France
- Communauté de Madrid, Provence-Alpes-Côte d'Azur
- Madrid, Marseille
- Université d'Aix-Marseille
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000145
- to stream Pmc, to step Curation: 000145
- to stream Pmc, to step Checkpoint: 000331
- to stream PubMed, to step Corpus: 000612
- to stream PubMed, to step Curation: 000590
- to stream PubMed, to step Checkpoint: 000590
- to stream Ncbi, to step Merge: 001341
- to stream Ncbi, to step Curation: 001341
- to stream Ncbi, to step Checkpoint: 001341
- to stream Main, to step Merge: 000925
- to stream Main, to step Curation: 000917
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses</title><author><name sortKey="Iba Ez, Kristina" sort="Iba Ez, Kristina" uniqKey="Iba Ez K" first="Kristina" last="Ibá Ez">Kristina Ibá Ez</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Boullosa, Cesar" sort="Boullosa, Cesar" uniqKey="Boullosa C" first="César" last="Boullosa">César Boullosa</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Baudot, Anais" sort="Baudot, Anais" uniqKey="Baudot A" first="Anaïs" last="Baudot">Anaïs Baudot</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24586201</idno><idno type="pmc">3930576</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930576</idno><idno type="RBID">PMC:3930576</idno><idno type="doi">10.1371/journal.pgen.1004173</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000145</idno><idno type="wicri:Area/Pmc/Curation">000145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000145</idno><idno type="wicri:Area/Pmc/Checkpoint">000331</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000331</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000612</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000612</idno><idno type="wicri:Area/PubMed/Curation">000590</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000590</idno><idno type="wicri:Area/PubMed/Checkpoint">000590</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000590</idno><idno type="wicri:Area/Ncbi/Merge">001341</idno><idno type="wicri:Area/Ncbi/Curation">001341</idno><idno type="wicri:Area/Ncbi/Checkpoint">001341</idno><idno type="wicri:doubleKey">1553-7390:2014:Iba Ez K:molecular:evidence:for</idno><idno type="wicri:Area/Main/Merge">000925</idno><idno type="wicri:Area/Main/Curation">000917</idno><idno type="wicri:Area/Main/Exploration">000917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses</title><author><name sortKey="Iba Ez, Kristina" sort="Iba Ez, Kristina" uniqKey="Iba Ez K" first="Kristina" last="Ibá Ez">Kristina Ibá Ez</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Boullosa, Cesar" sort="Boullosa, Cesar" uniqKey="Boullosa C" first="César" last="Boullosa">César Boullosa</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Baudot, Anais" sort="Baudot, Anais" uniqKey="Baudot A" first="Anaïs" last="Baudot">Anaïs Baudot</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (epidemiology)</term><term>Alzheimer Disease (genetics)</term><term>Alzheimer Disease (pathology)</term><term>Central Nervous System (pathology)</term><term>Comorbidity</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>NIMA-Interacting Peptidylprolyl Isomerase</term><term>Neoplasms (epidemiology)</term><term>Neoplasms (genetics)</term><term>Neoplasms (pathology)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Peptidylprolyl Isomerase (genetics)</term><term>Schizophrenia (epidemiology)</term><term>Schizophrenia (genetics)</term><term>Schizophrenia (pathology)</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidylprolyl Isomerase</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>NIMA-Interacting Peptidylprolyl Isomerase</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Alzheimer Disease</term><term>Neoplasms</term><term>Parkinson Disease</term><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Neoplasms</term><term>Parkinson Disease</term><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Central Nervous System</term><term>Neoplasms</term><term>Parkinson Disease</term><term>Schizophrenia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Comorbidity</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this <italic>inverse comorbidity</italic> is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with <italic>inverse comorbidities</italic>. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as well as between the genes downregulated in CNS disorders and upregulated in Cancers. We also observed expression deregulations in opposite directions at the level of pathways. Our analysis points to specific genes and pathways, the upregulation of which could increase the incidence of CNS disorders and simultaneously lower the risk of developing Cancer, while the downregulation of another set of genes and pathways could contribute to a decrease in the incidence of CNS disorders while increasing the Cancer risk. These results reinforce the previously proposed involvement of the <italic>PIN1</italic> gene, Wnt and P53 pathways, and reveal potential new candidates, in particular related with protein degradation processes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Dumont, N" uniqKey="Dumont N">N Dumont</name></author><author><name sortKey="Baudot, A" uniqKey="Baudot A">A Baudot</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Climent, J" uniqKey="Climent J">J Climent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Silva, M" uniqKey="Silva M">M Silva</name></author><author><name sortKey="Salech, F" uniqKey="Salech F">F Salech</name></author><author><name sortKey="Ponce, Dp" uniqKey="Ponce D">DP Ponce</name></author><author><name sortKey="Merino, D" uniqKey="Merino D">D Merino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Rubenstein, Jl" uniqKey="Rubenstein J">JL Rubenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Lendon, C" uniqKey="Lendon C">C Lendon</name></author><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devine, Mj" uniqKey="Devine M">MJ Devine</name></author><author><name sortKey="Plun Favreau, H" uniqKey="Plun Favreau H">H Plun-Favreau</name></author><author><name sortKey="Wood, Nw" uniqKey="Wood N">NW Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Crespo Facorro, B" uniqKey="Crespo Facorro B">B Crespo-Facorro</name></author><author><name sortKey="Vieta, E" uniqKey="Vieta E">E Vieta</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="West, Ab" uniqKey="West A">AB West</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musicco, M" uniqKey="Musicco M">M Musicco</name></author><author><name sortKey="Adorni, F" uniqKey="Adorni F">F Adorni</name></author><author><name sortKey="Di Santo, S" uniqKey="Di Santo S">S Di Santo</name></author><author><name sortKey="Prinelli, F" uniqKey="Prinelli F">F Prinelli</name></author><author><name sortKey="Pettenati, C" uniqKey="Pettenati C">C Pettenati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name></author><author><name sortKey="Neutel, D" uniqKey="Neutel D">D Neutel</name></author><author><name sortKey="Mestre, T" uniqKey="Mestre T">T Mestre</name></author><author><name sortKey="Coelho, M" uniqKey="Coelho M">M Coelho</name></author><author><name sortKey="Rosa, Mm" uniqKey="Rosa M">MM Rosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bajaj, A" uniqKey="Bajaj A">A Bajaj</name></author><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Schernhammer, Es" uniqKey="Schernhammer E">ES Schernhammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name></author><author><name sortKey="Yim, Sv" uniqKey="Yim S">SV Yim</name></author><author><name sortKey="Koh, Is" uniqKey="Koh I">IS Koh</name></author><author><name sortKey="Choi, Js" uniqKey="Choi J">JS Choi</name></author><author><name sortKey="Yoo, Jy" uniqKey="Yoo J">JY Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catts, Vs" uniqKey="Catts V">VS Catts</name></author><author><name sortKey="Catts, Sv" uniqKey="Catts S">SV Catts</name></author><author><name sortKey="O Toole, Bi" uniqKey="O Toole B">BI O'Toole</name></author><author><name sortKey="Frost, Ad" uniqKey="Frost A">AD Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, C Y" uniqKey="Lin C">C-Y Lin</name></author><author><name sortKey="Lane, H Y" uniqKey="Lane H">H-Y Lane</name></author><author><name sortKey="Chen, T T" uniqKey="Chen T">T-T Chen</name></author><author><name sortKey="Wu, Y H" uniqKey="Wu Y">Y-H Wu</name></author><author><name sortKey="Wu, C Y" uniqKey="Wu C">C-Y Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, G M" uniqKey="Lin G">G-M Lin</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y-J Chen</name></author><author><name sortKey="Kuo, D J" uniqKey="Kuo D">D-J Kuo</name></author><author><name sortKey="Jaiteh, Les" uniqKey="Jaiteh L">LES Jaiteh</name></author><author><name sortKey="Wu, Y C" uniqKey="Wu Y">Y-C Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Beiser, A" uniqKey="Beiser A">A Beiser</name></author><author><name sortKey="Au, R" uniqKey="Au R">R Au</name></author><author><name sortKey="Kreger, Be" uniqKey="Kreger B">BE Kreger</name></author><author><name sortKey="Splansky, Gl" uniqKey="Splansky G">GL Splansky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Miller, Jp" uniqKey="Miller J">JP Miller</name></author><author><name sortKey="Morris, Jc" uniqKey="Morris J">JC Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Fitzpatrick, Al" uniqKey="Fitzpatrick A">AL Fitzpatrick</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Sieh, W" uniqKey="Sieh W">W Sieh</name></author><author><name sortKey="Kuller, L" uniqKey="Kuller L">L Kuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Kp" uniqKey="Lu K">KP Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liou, Y C" uniqKey="Liou Y">Y-C Liou</name></author><author><name sortKey="Zhou, Xz" uniqKey="Zhou X">XZ Zhou</name></author><author><name sortKey="Lu, Kp" uniqKey="Lu K">KP Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cousin, E" uniqKey="Cousin E">E Cousin</name></author><author><name sortKey="Mace, S" uniqKey="Mace S">S Macé</name></author><author><name sortKey="Rocher, C" uniqKey="Rocher C">C Rocher</name></author><author><name sortKey="Dib, C" uniqKey="Dib C">C Dib</name></author><author><name sortKey="Muzard, G" uniqKey="Muzard G">G Muzard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cason, Al" uniqKey="Cason A">AL Cason</name></author><author><name sortKey="Ikeguchi, Y" uniqKey="Ikeguchi Y">Y Ikeguchi</name></author><author><name sortKey="Skinner, C" uniqKey="Skinner C">C Skinner</name></author><author><name sortKey="Wood, Tc" uniqKey="Wood T">TC Wood</name></author><author><name sortKey="Holden, Kr" uniqKey="Holden K">KR Holden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huber, M" uniqKey="Huber M">M Huber</name></author><author><name sortKey="Poulin, R" uniqKey="Poulin R">R Poulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bredel, M" uniqKey="Bredel M">M Bredel</name></author><author><name sortKey="Scholtens, Dm" uniqKey="Scholtens D">DM Scholtens</name></author><author><name sortKey="Yadav, Ak" uniqKey="Yadav A">AK Yadav</name></author><author><name sortKey="Alvarez, Aa" uniqKey="Alvarez A">AA Alvarez</name></author><author><name sortKey="Renfrow, Jj" uniqKey="Renfrow J">JJ Renfrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramanan, Vk" uniqKey="Ramanan V">VK Ramanan</name></author><author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name></author><author><name sortKey="Moore, Jh" uniqKey="Moore J">JH Moore</name></author><author><name sortKey="Saykin, Aj" uniqKey="Saykin A">AJ Saykin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author><author><name sortKey="Araki, M" uniqKey="Araki M">M Araki</name></author><author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name></author><author><name sortKey="Hattori, M" uniqKey="Hattori M">M Hattori</name></author><author><name sortKey="Hirakawa, M" uniqKey="Hirakawa M">M Hirakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, L" uniqKey="Matthews L">L Matthews</name></author><author><name sortKey="Gopinath, G" uniqKey="Gopinath G">G Gopinath</name></author><author><name sortKey="Gillespie, M" uniqKey="Gillespie M">M Gillespie</name></author><author><name sortKey="Caudy, M" uniqKey="Caudy M">M Caudy</name></author><author><name sortKey="Croft, D" uniqKey="Croft D">D Croft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Rubenstein, Jl" uniqKey="Rubenstein J">JL Rubenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okerlund, Nd" uniqKey="Okerlund N">ND Okerlund</name></author><author><name sortKey="Cheyette, Bnr" uniqKey="Cheyette B">BNR Cheyette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sachlos, E" uniqKey="Sachlos E">E Sachlos</name></author><author><name sortKey="Risue O, Rm" uniqKey="Risue O R">RM Risueño</name></author><author><name sortKey="Laronde, S" uniqKey="Laronde S">S Laronde</name></author><author><name sortKey="Shapovalova, Z" uniqKey="Shapovalova Z">Z Shapovalova</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J-H Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccall, Mn" uniqKey="Mccall M">MN McCall</name></author><author><name sortKey="Jaffee, Ha" uniqKey="Jaffee H">HA Jaffee</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gautier, L" uniqKey="Gautier L">L Gautier</name></author><author><name sortKey="Cope, L" uniqKey="Cope L">L Cope</name></author><author><name sortKey="Bolstad, Bm" uniqKey="Bolstad B">BM Bolstad</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Kang, Dd" uniqKey="Kang D">DD Kang</name></author><author><name sortKey="Shen, K" uniqKey="Shen K">K Shen</name></author><author><name sortKey="Song, C" uniqKey="Song C">C Song</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Jk" uniqKey="Choi J">JK Choi</name></author><author><name sortKey="Yu, U" uniqKey="Yu U">U Yu</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Yoo, Oj" uniqKey="Yoo O">OJ Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Gc" uniqKey="Tseng G">GC Tseng</name></author><author><name sortKey="Ghosh, D" uniqKey="Ghosh D">D Ghosh</name></author><author><name sortKey="Feingold, E" uniqKey="Feingold E">E Feingold</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name></author><author><name sortKey="Tamayo, P" uniqKey="Tamayo P">P Tamayo</name></author><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author><author><name sortKey="Mukherjee, S" uniqKey="Mukherjee S">S Mukherjee</name></author><author><name sortKey="Ebert, Bl" uniqKey="Ebert B">BL Ebert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li><li>France</li></country><region><li>Communauté de Madrid</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Madrid</li><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Iba Ez, Kristina" sort="Iba Ez, Kristina" uniqKey="Iba Ez K" first="Kristina" last="Ibá Ez">Kristina Ibá Ez</name></region><name sortKey="Boullosa, Cesar" sort="Boullosa, Cesar" uniqKey="Boullosa C" first="César" last="Boullosa">César Boullosa</name><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Baudot, Anais" sort="Baudot, Anais" uniqKey="Baudot A" first="Anaïs" last="Baudot">Anaïs Baudot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000917 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000917 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3930576
|texte= Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24586201" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |