Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
Identifieur interne : 000145 ( Pmc/Curation ); précédent : 000144; suivant : 000146Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
Auteurs : Kristina Ibá Ez [Espagne] ; César Boullosa [Espagne] ; Rafael Tabarés-Seisdedos [Espagne] ; Anaïs Baudot [France] ; Alfonso Valencia [Espagne]Source :
- PLoS Genetics [ 1553-7390 ] ; 2014.
Abstract
There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this
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DOI: 10.1371/journal.pgen.1004173
PubMed: 24586201
PubMed Central: 3930576
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses</title><author><name sortKey="Iba Ez, Kristina" sort="Iba Ez, Kristina" uniqKey="Iba Ez K" first="Kristina" last="Ibá Ez">Kristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Boullosa, Cesar" sort="Boullosa, Cesar" uniqKey="Boullosa C" first="César" last="Boullosa">César Boullosa</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Baudot, Anais" sort="Baudot, Anais" uniqKey="Baudot A" first="Anaïs" last="Baudot">Anaïs Baudot</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24586201</idno><idno type="pmc">3930576</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930576</idno><idno type="RBID">PMC:3930576</idno><idno type="doi">10.1371/journal.pgen.1004173</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000145</idno><idno type="wicri:Area/Pmc/Curation">000145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000145</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses</title><author><name sortKey="Iba Ez, Kristina" sort="Iba Ez, Kristina" uniqKey="Iba Ez K" first="Kristina" last="Ibá Ez">Kristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Boullosa, Cesar" sort="Boullosa, Cesar" uniqKey="Boullosa C" first="César" last="Boullosa">César Boullosa</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Tabares Seisdedos, Rafael" sort="Tabares Seisdedos, Rafael" uniqKey="Tabares Seisdedos R" first="Rafael" last="Tabarés-Seisdedos">Rafael Tabarés-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Baudot, Anais" sort="Baudot, Anais" uniqKey="Baudot A" first="Anaïs" last="Baudot">Anaïs Baudot</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Valencia, Alfonso" sort="Valencia, Alfonso" uniqKey="Valencia A" first="Alfonso" last="Valencia">Alfonso Valencia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS Genetics</title><idno type="ISSN">1553-7390</idno><idno type="eISSN">1553-7404</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this <italic>inverse comorbidity</italic> is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with <italic>inverse comorbidities</italic>. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as well as between the genes downregulated in CNS disorders and upregulated in Cancers. We also observed expression deregulations in opposite directions at the level of pathways. Our analysis points to specific genes and pathways, the upregulation of which could increase the incidence of CNS disorders and simultaneously lower the risk of developing Cancer, while the downregulation of another set of genes and pathways could contribute to a decrease in the incidence of CNS disorders while increasing the Cancer risk. These results reinforce the previously proposed involvement of the <italic>PIN1</italic> gene, Wnt and P53 pathways, and reveal potential new candidates, in particular related with protein degradation processes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Dumont, N" uniqKey="Dumont N">N Dumont</name></author><author><name sortKey="Baudot, A" uniqKey="Baudot A">A Baudot</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Climent, J" uniqKey="Climent J">J Climent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Silva, M" uniqKey="Silva M">M Silva</name></author><author><name sortKey="Salech, F" uniqKey="Salech F">F Salech</name></author><author><name sortKey="Ponce, Dp" uniqKey="Ponce D">DP Ponce</name></author><author><name sortKey="Merino, D" uniqKey="Merino D">D Merino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Rubenstein, Jl" uniqKey="Rubenstein J">JL Rubenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Lendon, C" uniqKey="Lendon C">C Lendon</name></author><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devine, Mj" uniqKey="Devine M">MJ Devine</name></author><author><name sortKey="Plun Favreau, H" uniqKey="Plun Favreau H">H Plun-Favreau</name></author><author><name sortKey="Wood, Nw" uniqKey="Wood N">NW Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala L Pez, F" uniqKey="Catala L Pez F">F Catalá-López</name></author><author><name sortKey="Crespo Facorro, B" uniqKey="Crespo Facorro B">B Crespo-Facorro</name></author><author><name sortKey="Vieta, E" uniqKey="Vieta E">E Vieta</name></author><author><name sortKey="Valderas, Jm" uniqKey="Valderas J">JM Valderas</name></author><author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="West, Ab" uniqKey="West A">AB West</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musicco, M" uniqKey="Musicco M">M Musicco</name></author><author><name sortKey="Adorni, F" uniqKey="Adorni F">F Adorni</name></author><author><name sortKey="Di Santo, S" uniqKey="Di Santo S">S Di Santo</name></author><author><name sortKey="Prinelli, F" uniqKey="Prinelli F">F Prinelli</name></author><author><name sortKey="Pettenati, C" uniqKey="Pettenati C">C Pettenati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferreira, Jj" uniqKey="Ferreira J">JJ Ferreira</name></author><author><name sortKey="Neutel, D" uniqKey="Neutel D">D Neutel</name></author><author><name sortKey="Mestre, T" uniqKey="Mestre T">T Mestre</name></author><author><name sortKey="Coelho, M" uniqKey="Coelho M">M Coelho</name></author><author><name sortKey="Rosa, Mm" uniqKey="Rosa M">MM Rosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bajaj, A" uniqKey="Bajaj A">A Bajaj</name></author><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Schernhammer, Es" uniqKey="Schernhammer E">ES Schernhammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name></author><author><name sortKey="Yim, Sv" uniqKey="Yim S">SV Yim</name></author><author><name sortKey="Koh, Is" uniqKey="Koh I">IS Koh</name></author><author><name sortKey="Choi, Js" uniqKey="Choi J">JS Choi</name></author><author><name sortKey="Yoo, Jy" uniqKey="Yoo J">JY Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catts, Vs" uniqKey="Catts V">VS Catts</name></author><author><name sortKey="Catts, Sv" uniqKey="Catts S">SV Catts</name></author><author><name sortKey="O Toole, Bi" uniqKey="O Toole B">BI O'Toole</name></author><author><name sortKey="Frost, Ad" uniqKey="Frost A">AD Frost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, C Y" uniqKey="Lin C">C-Y Lin</name></author><author><name sortKey="Lane, H Y" uniqKey="Lane H">H-Y Lane</name></author><author><name sortKey="Chen, T T" uniqKey="Chen T">T-T Chen</name></author><author><name sortKey="Wu, Y H" uniqKey="Wu Y">Y-H Wu</name></author><author><name sortKey="Wu, C Y" uniqKey="Wu C">C-Y Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, G M" uniqKey="Lin G">G-M Lin</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y-J Chen</name></author><author><name sortKey="Kuo, D J" uniqKey="Kuo D">D-J Kuo</name></author><author><name sortKey="Jaiteh, Les" uniqKey="Jaiteh L">LES Jaiteh</name></author><author><name sortKey="Wu, Y C" uniqKey="Wu Y">Y-C Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author><author><name sortKey="Beiser, A" uniqKey="Beiser A">A Beiser</name></author><author><name sortKey="Au, R" uniqKey="Au R">R Au</name></author><author><name sortKey="Kreger, Be" uniqKey="Kreger B">BE Kreger</name></author><author><name sortKey="Splansky, Gl" uniqKey="Splansky G">GL Splansky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Behrens, Mi" uniqKey="Behrens M">MI Behrens</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Miller, Jp" uniqKey="Miller J">JP Miller</name></author><author><name sortKey="Morris, Jc" uniqKey="Morris J">JC Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roe, Cm" uniqKey="Roe C">CM Roe</name></author><author><name sortKey="Fitzpatrick, Al" uniqKey="Fitzpatrick A">AL Fitzpatrick</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C Xiong</name></author><author><name sortKey="Sieh, W" uniqKey="Sieh W">W Sieh</name></author><author><name sortKey="Kuller, L" uniqKey="Kuller L">L Kuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Kp" uniqKey="Lu K">KP Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liou, Y C" uniqKey="Liou Y">Y-C Liou</name></author><author><name sortKey="Zhou, Xz" uniqKey="Zhou X">XZ Zhou</name></author><author><name sortKey="Lu, Kp" uniqKey="Lu K">KP Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cousin, E" uniqKey="Cousin E">E Cousin</name></author><author><name sortKey="Mace, S" uniqKey="Mace S">S Macé</name></author><author><name sortKey="Rocher, C" uniqKey="Rocher C">C Rocher</name></author><author><name sortKey="Dib, C" uniqKey="Dib C">C Dib</name></author><author><name sortKey="Muzard, G" uniqKey="Muzard G">G Muzard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cason, Al" uniqKey="Cason A">AL Cason</name></author><author><name sortKey="Ikeguchi, Y" uniqKey="Ikeguchi Y">Y Ikeguchi</name></author><author><name sortKey="Skinner, C" uniqKey="Skinner C">C Skinner</name></author><author><name sortKey="Wood, Tc" uniqKey="Wood T">TC Wood</name></author><author><name sortKey="Holden, Kr" uniqKey="Holden K">KR Holden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huber, M" uniqKey="Huber M">M Huber</name></author><author><name sortKey="Poulin, R" uniqKey="Poulin R">R Poulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bredel, M" uniqKey="Bredel M">M Bredel</name></author><author><name sortKey="Scholtens, Dm" uniqKey="Scholtens D">DM Scholtens</name></author><author><name sortKey="Yadav, Ak" uniqKey="Yadav A">AK Yadav</name></author><author><name sortKey="Alvarez, Aa" uniqKey="Alvarez A">AA Alvarez</name></author><author><name sortKey="Renfrow, Jj" uniqKey="Renfrow J">JJ Renfrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramanan, Vk" uniqKey="Ramanan V">VK Ramanan</name></author><author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name></author><author><name sortKey="Moore, Jh" uniqKey="Moore J">JH Moore</name></author><author><name sortKey="Saykin, Aj" uniqKey="Saykin A">AJ Saykin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author><author><name sortKey="Araki, M" uniqKey="Araki M">M Araki</name></author><author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name></author><author><name sortKey="Hattori, M" uniqKey="Hattori M">M Hattori</name></author><author><name sortKey="Hirakawa, M" uniqKey="Hirakawa M">M Hirakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, L" uniqKey="Matthews L">L Matthews</name></author><author><name sortKey="Gopinath, G" uniqKey="Gopinath G">G Gopinath</name></author><author><name sortKey="Gillespie, M" uniqKey="Gillespie M">M Gillespie</name></author><author><name sortKey="Caudy, M" uniqKey="Caudy M">M Caudy</name></author><author><name sortKey="Croft, D" uniqKey="Croft D">D Croft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabares Seisdedos, R" uniqKey="Tabares Seisdedos R">R Tabarés-Seisdedos</name></author><author><name sortKey="Rubenstein, Jl" uniqKey="Rubenstein J">JL Rubenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okerlund, Nd" uniqKey="Okerlund N">ND Okerlund</name></author><author><name sortKey="Cheyette, Bnr" uniqKey="Cheyette B">BNR Cheyette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sachlos, E" uniqKey="Sachlos E">E Sachlos</name></author><author><name sortKey="Risue O, Rm" uniqKey="Risue O R">RM Risueño</name></author><author><name sortKey="Laronde, S" uniqKey="Laronde S">S Laronde</name></author><author><name sortKey="Shapovalova, Z" uniqKey="Shapovalova Z">Z Shapovalova</name></author><author><name sortKey="Lee, J H" uniqKey="Lee J">J-H Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccall, Mn" uniqKey="Mccall M">MN McCall</name></author><author><name sortKey="Jaffee, Ha" uniqKey="Jaffee H">HA Jaffee</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gautier, L" uniqKey="Gautier L">L Gautier</name></author><author><name sortKey="Cope, L" uniqKey="Cope L">L Cope</name></author><author><name sortKey="Bolstad, Bm" uniqKey="Bolstad B">BM Bolstad</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Kang, Dd" uniqKey="Kang D">DD Kang</name></author><author><name sortKey="Shen, K" uniqKey="Shen K">K Shen</name></author><author><name sortKey="Song, C" uniqKey="Song C">C Song</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Jk" uniqKey="Choi J">JK Choi</name></author><author><name sortKey="Yu, U" uniqKey="Yu U">U Yu</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Yoo, Oj" uniqKey="Yoo O">OJ Yoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Gc" uniqKey="Tseng G">GC Tseng</name></author><author><name sortKey="Ghosh, D" uniqKey="Ghosh D">D Ghosh</name></author><author><name sortKey="Feingold, E" uniqKey="Feingold E">E Feingold</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name></author><author><name sortKey="Tamayo, P" uniqKey="Tamayo P">P Tamayo</name></author><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author><author><name sortKey="Mukherjee, S" uniqKey="Mukherjee S">S Mukherjee</name></author><author><name sortKey="Ebert, Bl" uniqKey="Ebert B">BL Ebert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Genet</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Genet</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosgen</journal-id><journal-title-group><journal-title>PLoS Genetics</journal-title></journal-title-group><issn pub-type="ppub">1553-7390</issn><issn pub-type="epub">1553-7404</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24586201</article-id><article-id pub-id-type="pmc">3930576</article-id><article-id pub-id-type="publisher-id">PGENETICS-D-13-02537</article-id><article-id pub-id-type="doi">10.1371/journal.pgen.1004173</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Computational Biology</subject></subj-group><subj-group><subject>Genetics</subject><subj-group><subject>Cancer Genetics</subject><subject>Gene Expression</subject><subject>Gene Networks</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses</article-title><alt-title alt-title-type="running-head">Inverse Comorbidity among Cancer and CNS Disorders</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Ibáñez</surname><given-names>Kristina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Boullosa</surname><given-names>César</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tabarés-Seisdedos</surname><given-names>Rafael</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Baudot</surname><given-names>Anaïs</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Valencia</surname><given-names>Alfonso</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Structural Biology and Biocomputing Programme, Spanish National Cancer, Research Centre (CNIO), Madrid, Spain</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia, Spain</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Aix-Marseille Université, CNRS, I2M, UMR 7373, Marseille, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Horwitz</surname><given-names>Marshall S.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Washington, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>anais.baudot@univ-amu.fr</email> (AB); <email>avalencia@cnio.es</email> (AV)</corresp><fn fn-type="conflict"><p>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: KI CB RTS AB AV. Performed the experiments: KI CB. Analyzed the data: KI CB. Contributed reagents/materials/analysis tools: KI CB AB. Wrote the paper: AB. Oversaw and reviewed the whole study: AV RTS. Drew figures and tables: KI CB. Network figure: AB.</p></fn></author-notes><pub-date pub-type="collection"><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>20</day><month>2</month><year>2014</year></pub-date><volume>10</volume><issue>2</issue><elocation-id>e1004173</elocation-id><history><date date-type="received"><day>16</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>30</day><month>12</month><year>2013</year></date></history><permissions><copyright-statement>© 2014 Ibáñez et al</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Ibáñez et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><abstract><p>There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this <italic>inverse comorbidity</italic> is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with <italic>inverse comorbidities</italic>. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as well as between the genes downregulated in CNS disorders and upregulated in Cancers. We also observed expression deregulations in opposite directions at the level of pathways. Our analysis points to specific genes and pathways, the upregulation of which could increase the incidence of CNS disorders and simultaneously lower the risk of developing Cancer, while the downregulation of another set of genes and pathways could contribute to a decrease in the incidence of CNS disorders while increasing the Cancer risk. These results reinforce the previously proposed involvement of the <italic>PIN1</italic> gene, Wnt and P53 pathways, and reveal potential new candidates, in particular related with protein degradation processes.</p></abstract><abstract abstract-type="summary"><title>Author Summary</title><p>A lower-than-expected probability of developing certain types of Cancer has been observed in patients with CNS disorders, including Alzheimer's disease, Parkinson's disease or Schizophrenia. Understanding such a protective effect could be the key to finding novel treatments for both types of conditions, for instance thanks to drug repurposing. However, little is known about the underlying mechanisms for these intriguing <italic>inverse comorbidities</italic>. Although environmental causes, drug treatments or lower screening surveys might contribute to the <italic>inverse comorbidity</italic> between complex disorders, we propose that <italic>inverse comorbidity</italic> is, at least in part, due to genetic factors. </p><p>We observe here that a common set of genes and biological processes are deregulated in opposite directions in CNS disorders and Cancers, <italic>i.e.</italic> upregulated in CNS disorders and downregulated in Cancers, or vice versa. We propose the alluring hypothesis that the deregulation of these genes and processes could promote CNS disorders and simultaneously lower the initiation or progression of Cancers.</p></abstract><funding-group><funding-statement>This work was supported by a Fellowship from Obra Social la Caixa grant to KI (<ext-link ext-link-type="uri" xlink:href="http://obrasocial.lacaixa.es/laCaixaFoundation/home_en.html">http://obrasocial.lacaixa.es/laCaixaFoundation/home_en.html</ext-link>), FPI grant BES-2008-006332 to CB and grant BIO2012 to AV Group. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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