Autophagy in Pancreatic Cancer
Identifieur interne : 001170 ( Main/Exploration ); précédent : 001169; suivant : 001171Autophagy in Pancreatic Cancer
Auteurs : Daniel Grasso [France] ; Maria Noé Garcia [France] ; Juan L. Iovanna [France]Source :
- International Journal of Cell Biology [ 1687-8876 ] ; 2012.
Abstract
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.
Url:
DOI: 10.1155/2012/760498
PubMed: 22291707
PubMed Central: 3265076
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000971
- to stream Pmc, to step Curation: 000967
- to stream Pmc, to step Checkpoint: 000640
- to stream Ncbi, to step Merge: 000E41
- to stream Ncbi, to step Curation: 000E41
- to stream Ncbi, to step Checkpoint: 000E41
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Le document en format XML
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Iovanna</name><affiliation wicri:level="3"><nlm:aff id="I1">Parc Scientifique et Technologique de Luminy, Stress Cellulaire, INSERM U624, 163 avenue de Luminy, CP 915, 13288 Marseille Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Parc Scientifique et Technologique de Luminy, Stress Cellulaire, INSERM U624, 163 avenue de Luminy, CP 915, 13288 Marseille Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Cell Biology</title><idno type="ISSN">1687-8876</idno><idno type="eISSN">1687-8884</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Farre, Jc" uniqKey="Farre J">JC Farré</name></author><author><name sortKey="Krick, R" uniqKey="Krick R">R Krick</name></author><author><name sortKey="Subramani, S" uniqKey="Subramani S">S Subramani</name></author><author><name sortKey="Thumm, M" uniqKey="Thumm M">M Thumm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ 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Trimmer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Grasso, Daniel" sort="Grasso, Daniel" uniqKey="Grasso D" first="Daniel" last="Grasso">Daniel Grasso</name></region><name sortKey="Garcia, Maria Noe" sort="Garcia, Maria Noe" uniqKey="Garcia M" first="Maria Noé" last="Garcia">Maria Noé Garcia</name><name sortKey="Iovanna, Juan L" sort="Iovanna, Juan L" uniqKey="Iovanna J" first="Juan L." last="Iovanna">Juan L. 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