Motor signs during the course of Alzheimer disease
Identifieur interne : 003002 ( Main/Exploration ); précédent : 003001; suivant : 003003Motor signs during the course of Alzheimer disease
Auteurs : N. Scarmeas [États-Unis, Grèce] ; G. M. Hadjigeorgiou [Grèce] ; A. Papadimitriou [Grèce] ; B. Dubois [France] ; M. Sarazin [France] ; J. Brandt [États-Unis] ; M. Albert [États-Unis] ; K. Marder [États-Unis] ; K. Bell [États-Unis] ; L. S. Honig [États-Unis] ; D. Wegesin [États-Unis] ; Y. Stern [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care. Objective: To describe the progression and identify predictors of individual MOSIs in AD. Methods: A cohort of 474 patients with AD at early stages was followed semiannually for up to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits/assessments of MOSIs (average 6.4/patient) were performed. Prevalence and incidence rates were calculated, and cumulative risk graphs were plotted for individual non-drug-induced MOSI domains. Rates of change over time taking into account potential covariates were also estimated. With use of each MOSI domain as outcome in Cox models, predictors of MOSI incidence were identified. Results: At least one MOSI was detected in 13% of patients at first examination and in 36% for the last evaluation. Total MOSI score increased at an annual rate of 3% of total possible score. Rates of annual change for speech/facial expression (4%), rigidity (2.45%), posture/gait (3.9%), and bradykinesia (3.75%) were of similar magnitude, and their occurrence increased from first (3 to 6%) to last (22 to 29%) evaluation. Tremor was less frequent throughout the course of the disease (4% at first and 7% at last evaluation) and worsened less (0.75% increase/year). Conclusions: Most motor signs occur frequently and progress rapidly in Alzheimer disease. Tremor is an exception in that it occurs less frequently and advances at slower rates.
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Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, G M" sort="Hadjigeorgiou, G M" uniqKey="Hadjigeorgiou G" first="G. M." last="Hadjigeorgiou">G. M. 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Marder</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bell, K" sort="Bell, K" uniqKey="Bell K" first="K." last="Bell">K. Bell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Honig, L S" sort="Honig, L S" uniqKey="Honig L" first="L. S." last="Honig">L. S. Honig</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. 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Scarmeas</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, G M" sort="Hadjigeorgiou, G M" uniqKey="Hadjigeorgiou G" first="G. M." last="Hadjigeorgiou">G. M. Hadjigeorgiou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Papadimitriou, A" sort="Papadimitriou, A" uniqKey="Papadimitriou A" first="A." last="Papadimitriou">A. Papadimitriou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de la Salpetriere,</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sarazin, M" sort="Sarazin, M" uniqKey="Sarazin M" first="M." last="Sarazin">M. Sarazin</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Hospital de la Salpetriere,</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brandt, J" sort="Brandt, J" uniqKey="Brandt J" first="J." last="Brandt">J. Brandt</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Albert, M" sort="Albert, M" uniqKey="Albert M" first="M." last="Albert">M. Albert</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K." last="Marder">K. Marder</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bell, K" sort="Bell, K" uniqKey="Bell K" first="K." last="Bell">K. Bell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Honig, L S" sort="Honig, L S" uniqKey="Honig L" first="L. S." last="Honig">L. S. Honig</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wegesin, D" sort="Wegesin, D" uniqKey="Wegesin D" first="D." last="Wegesin">D. Wegesin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Columbia University Medical Center</s1><s2>New York</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Nervous system diseases</term><term>Sign</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Signe</term><term>Démence Alzheimer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care. Objective: To describe the progression and identify predictors of individual MOSIs in AD. Methods: A cohort of 474 patients with AD at early stages was followed semiannually for up to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits/assessments of MOSIs (average 6.4/patient) were performed. Prevalence and incidence rates were calculated, and cumulative risk graphs were plotted for individual non-drug-induced MOSI domains. Rates of change over time taking into account potential covariates were also estimated. With use of each MOSI domain as outcome in Cox models, predictors of MOSI incidence were identified. Results: At least one MOSI was detected in 13% of patients at first examination and in 36% for the last evaluation. Total MOSI score increased at an annual rate of 3% of total possible score. Rates of annual change for speech/facial expression (4%), rigidity (2.45%), posture/gait (3.9%), and bradykinesia (3.75%) were of similar magnitude, and their occurrence increased from first (3 to 6%) to last (22 to 29%) evaluation. Tremor was less frequent throughout the course of the disease (4% at first and 7% at last evaluation) and worsened less (0.75% increase/year). Conclusions: Most motor signs occur frequently and progress rapidly in Alzheimer disease. Tremor is an exception in that it occurs less frequently and advances at slower rates.</div></front></TEI><affiliations><list><country><li>France</li><li>Grèce</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Boston</li><li>Paris</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Scarmeas, N" sort="Scarmeas, N" uniqKey="Scarmeas N" first="N." last="Scarmeas">N. Scarmeas</name></region><name sortKey="Albert, M" sort="Albert, M" uniqKey="Albert M" first="M." last="Albert">M. Albert</name><name sortKey="Bell, K" sort="Bell, K" uniqKey="Bell K" first="K." last="Bell">K. Bell</name><name sortKey="Brandt, J" sort="Brandt, J" uniqKey="Brandt J" first="J." last="Brandt">J. Brandt</name><name sortKey="Honig, L S" sort="Honig, L S" uniqKey="Honig L" first="L. S." last="Honig">L. S. Honig</name><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K." last="Marder">K. Marder</name><name sortKey="Stern, Y" sort="Stern, Y" uniqKey="Stern Y" first="Y." last="Stern">Y. Stern</name><name sortKey="Wegesin, D" sort="Wegesin, D" uniqKey="Wegesin D" first="D." last="Wegesin">D. Wegesin</name></country><country name="Grèce"><noRegion><name sortKey="Scarmeas, N" sort="Scarmeas, N" uniqKey="Scarmeas N" first="N." last="Scarmeas">N. Scarmeas</name></noRegion><name sortKey="Hadjigeorgiou, G M" sort="Hadjigeorgiou, G M" uniqKey="Hadjigeorgiou G" first="G. M." last="Hadjigeorgiou">G. M. Hadjigeorgiou</name><name sortKey="Papadimitriou, A" sort="Papadimitriou, A" uniqKey="Papadimitriou A" first="A." last="Papadimitriou">A. Papadimitriou</name></country><country name="France"><region name="Île-de-France"><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B." last="Dubois">B. Dubois</name></region><name sortKey="Sarazin, M" sort="Sarazin, M" uniqKey="Sarazin M" first="M." last="Sarazin">M. Sarazin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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