Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat
Identifieur interne : 004F46 ( Main/Exploration ); précédent : 004F45; suivant : 004F47Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat
Auteurs : M. Luotamo [Finlande] ; E. Elovaara [Finlande] ; H. Raunio [Finlande] ; O. Pelkonen [Finlande] ; V. Riihim Ki [Finlande] ; H. Vainio [France]Source :
- Archives of Toxicology [ 0340-5761 ] ; 1991-10-01.
Abstract
Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.
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DOI: 10.1007/BF02098033
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Raunio</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pharmacology, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Pelkonen, O" sort="Pelkonen, O" uniqKey="Pelkonen O" first="O." last="Pelkonen">O. Pelkonen</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pharmacology, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Riihim Ki, V" sort="Riihim Ki, V" uniqKey="Riihim Ki V" first="V." last="Riihim Ki">V. Riihim Ki</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vainio, H" sort="Vainio, H" uniqKey="Vainio H" first="H." last="Vainio">H. 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Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="Finlande"><noRegion><name sortKey="Luotamo, M" sort="Luotamo, M" uniqKey="Luotamo M" first="M." last="Luotamo">M. Luotamo</name></noRegion><name sortKey="Elovaara, E" sort="Elovaara, E" uniqKey="Elovaara E" first="E." last="Elovaara">E. Elovaara</name><name sortKey="Pelkonen, O" sort="Pelkonen, O" uniqKey="Pelkonen O" first="O." last="Pelkonen">O. Pelkonen</name><name sortKey="Raunio, H" sort="Raunio, H" uniqKey="Raunio H" first="H." last="Raunio">H. Raunio</name><name sortKey="Riihim Ki, V" sort="Riihim Ki, V" uniqKey="Riihim Ki V" first="V." last="Riihim Ki">V. Riihim Ki</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vainio, H" sort="Vainio, H" uniqKey="Vainio H" first="H." last="Vainio">H. Vainio</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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