Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat
Identifieur interne : 000A37 ( Istex/Corpus ); précédent : 000A36; suivant : 000A38Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat
Auteurs : M. Luotamo ; E. Elovaara ; H. Raunio ; O. Pelkonen ; V. Riihim Ki ; H. VainioSource :
- Archives of Toxicology [ 0340-5761 ] ; 1991-10-01.
Abstract
Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.
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DOI: 10.1007/BF02098033
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title><author><name sortKey="Luotamo, M" sort="Luotamo, M" uniqKey="Luotamo M" first="M." last="Luotamo">M. Luotamo</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Elovaara, E" sort="Elovaara, E" uniqKey="Elovaara E" first="E." last="Elovaara">E. Elovaara</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Raunio, H" sort="Raunio, H" uniqKey="Raunio H" first="H." last="Raunio">H. Raunio</name><affiliation><mods:affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</mods:affiliation></affiliation></author><author><name sortKey="Pelkonen, O" sort="Pelkonen, O" uniqKey="Pelkonen O" first="O." last="Pelkonen">O. Pelkonen</name><affiliation><mods:affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</mods:affiliation></affiliation></author><author><name sortKey="Riihim Ki, V" sort="Riihim Ki, V" uniqKey="Riihim Ki V" first="V." last="Riihim Ki">V. Riihim Ki</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Vainio, H" sort="Vainio, H" uniqKey="Vainio H" first="H." last="Vainio">H. Vainio</name><affiliation><mods:affiliation>International Agency for Research on Cancer, Lyon, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1007/BF02098033</idno><idno type="url">https://api.istex.fr/document/CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000A37</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000A37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title><author><name sortKey="Luotamo, M" sort="Luotamo, M" uniqKey="Luotamo M" first="M." last="Luotamo">M. Luotamo</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Elovaara, E" sort="Elovaara, E" uniqKey="Elovaara E" first="E." last="Elovaara">E. Elovaara</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Raunio, H" sort="Raunio, H" uniqKey="Raunio H" first="H." last="Raunio">H. Raunio</name><affiliation><mods:affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</mods:affiliation></affiliation></author><author><name sortKey="Pelkonen, O" sort="Pelkonen, O" uniqKey="Pelkonen O" first="O." last="Pelkonen">O. Pelkonen</name><affiliation><mods:affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</mods:affiliation></affiliation></author><author><name sortKey="Riihim Ki, V" sort="Riihim Ki, V" uniqKey="Riihim Ki V" first="V." last="Riihim Ki">V. Riihim Ki</name><affiliation><mods:affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Vainio, H" sort="Vainio, H" uniqKey="Vainio H" first="H." last="Vainio">H. Vainio</name><affiliation><mods:affiliation>International Agency for Research on Cancer, Lyon, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Toxicology</title><title level="j" type="abbrev">Arch Toxicol</title><idno type="ISSN">0340-5761</idno><idno type="eISSN">1432-0738</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-10-01">1991-10-01</date><biblScope unit="volume">65</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="661">661</biblScope><biblScope unit="page" to="665">665</biblScope></imprint><idno type="ISSN">0340-5761</idno></series><idno type="istex">CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D</idno><idno type="DOI">10.1007/BF02098033</idno><idno type="ArticleID">BF02098033</idno><idno type="ArticleID">Art9</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-5761</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>M. Luotamo</name><affiliations><json:string>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>E. Elovaara</name><affiliations><json:string>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>H. Raunio</name><affiliations><json:string>Department of Pharmacology, University of Oulu, Oulu, Finland</json:string></affiliations></json:item><json:item><name>O. Pelkonen</name><affiliations><json:string>Department of Pharmacology, University of Oulu, Oulu, Finland</json:string></affiliations></json:item><json:item><name>V. Riihimäki</name><affiliations><json:string>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</json:string></affiliations></json:item><json:item><name>H. Vainio</name><affiliations><json:string>International Agency for Research on Cancer, Lyon, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>245-HCB : 2,2′,4,4′,5,5′-hexachlorobiphenyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>236-HCB : 2,2′,3,3′,6,6′-hexachlorobiphenyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mab : monoclonal antibody</value></json:item></subject><articleId><json:string>BF02098033</json:string><json:string>Art9</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. 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Wyss</name></json:item><json:item><name>S Miihlebach</name></json:item><json:item><name>Mh Bickel</name></json:item></author><title>Pharmacokinetics of</title><publicationDate>1982</publicationDate></host></json:item><json:item><author></author><host><volume>10</volume><pages><last>661</last><first>657</first></pages><author></author><title>Drug Metab Dispos</title></host><title>5,5'-hexachlorobiphenyl (6-CB) in rats with decreasing adipose tissue mass</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>65</volume><pages><last>665</last><first>661</first></pages><issn><json:string>0340-5761</json:string></issn><issue>8</issue><subject><json:item><value>Cancer Research</value></json:item><json:item><value>Pharmacology/Toxicology</value></json:item><json:item><value>Allergology</value></json:item></subject><journalId><json:string>204</json:string></journalId><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1432-0738</json:string></eissn><title>Archives of Toxicology</title><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate></host><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><doi><json:string>10.1007/BF02098033</json:string></doi><id>CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D</id><score>0.13293952</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1991</p></availability><date>1991</date></publicationStmt><notesStmt><note>Original Investigations</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title><author xml:id="author-1" corresp="yes"><persName><forename type="first">M.</forename><surname>Luotamo</surname></persName><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation></author><author xml:id="author-2"><persName><forename type="first">E.</forename><surname>Elovaara</surname></persName><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation></author><author xml:id="author-3"><persName><forename type="first">H.</forename><surname>Raunio</surname></persName><affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</affiliation></author><author xml:id="author-4"><persName><forename type="first">O.</forename><surname>Pelkonen</surname></persName><affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</affiliation></author><author xml:id="author-5"><persName><forename type="first">V.</forename><surname>Riihimäki</surname></persName><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation></author><author xml:id="author-6"><persName><forename type="first">H.</forename><surname>Vainio</surname></persName><affiliation>International Agency for Research on Cancer, Lyon, France</affiliation></author></analytic><monogr><title level="j">Archives of Toxicology</title><title level="j" type="abbrev">Arch Toxicol</title><idno type="journal-ID">204</idno><idno type="pISSN">0340-5761</idno><idno type="eISSN">1432-0738</idno><idno type="issue-article-count">16</idno><idno type="volume-issue-count">8</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-10-01"></date><biblScope unit="volume">65</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="661">661</biblScope><biblScope unit="page" to="665">665</biblScope></imprint></monogr><idno type="istex">CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D</idno><idno type="DOI">10.1007/BF02098033</idno><idno type="ArticleID">BF02098033</idno><idno type="ArticleID">Art9</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1991</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>245-HCB</term><term>2,2′,4,4′,5,5′-hexachlorobiphenyl</term></item><item><term>236-HCB</term><term>2,2′,3,3′,6,6′-hexachlorobiphenyl</term></item><item><term>Mab</term><term>monoclonal antibody</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Cancer Research</term></item><item><term>Pharmacology/Toxicology</term></item><item><term>Allergology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991-10-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-22">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-20">References 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Toxicology</JournalTitle><JournalAbbreviatedTitle>Arch Toxicol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Cancer Research</JournalSubject><JournalSubject Type="Secondary">Pharmacology/Toxicology</JournalSubject><JournalSubject Type="Secondary">Allergology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>65</VolumeIDStart><VolumeIDEnd>65</VolumeIDEnd><VolumeIssueCount>8</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>8</IssueIDStart><IssueIDEnd>8</IssueIDEnd><IssueArticleCount>16</IssueArticleCount><IssueHistory><CoverDate><Year>1991</Year><Month>10</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art9"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02098033</ArticleID><ArticleDOI>10.1007/BF02098033</ArticleDOI><ArticleSequenceNumber>9</ArticleSequenceNumber><ArticleTitle Language="En">Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>661</ArticleFirstPage><ArticleLastPage>665</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>8</Month><Day>2</Day></RegistrationDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>204</JournalID><VolumeIDStart>65</VolumeIDStart><VolumeIDEnd>65</VolumeIDEnd><IssueIDStart>8</IssueIDStart><IssueIDEnd>8</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Luotamo</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Elovaara</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3" PresentAffiliationID="Aff4"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Raunio</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>O.</GivenName><FamilyName>Pelkonen</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><FamilyName>Riihimäki</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff5"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Vainio</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Industrial Hygiene and Toxicology</OrgDivision><OrgName>Institute of Occupational Health</OrgName><OrgAddress><City>Helsinki</City><Country>Finland</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Pharmacology</OrgDivision><OrgName>University of Oulu</OrgName><OrgAddress><City>Oulu</City><Country>Finland</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgName>International Agency for Research on Cancer</OrgName><OrgAddress><City>Lyon</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>LEC</OrgDivision><OrgName>National Institutes of Health NCI</OrgName><OrgAddress><Street>Bldg 37, Rm 3C27</Street><City>Bethesda</City><State>Maryland</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Laboratory of Biochemistry</OrgDivision><OrgName>Institute of Occupational Health</OrgName><OrgAddress><Street>Arinatie 3</Street><Postcode>SF-00370</Postcode><City>Helsinki</City><Country>Finland</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Polychlorinated biphenyls</Keyword><Keyword>2,2′,3,3′,6,6′-hexachlorobiphenyl</Keyword><Keyword>2,2′,4,4′,5,5′-hexachlorobiphenyl</Keyword><Keyword>Cytochrome P450 isoenzymes</Keyword><Keyword>Enzyme induction</Keyword><Keyword>Rat</Keyword></KeywordGroup><AbbreviationGroup><Heading>Abbreviations</Heading><DefinitionList><DefinitionListEntry><Term>245-HCB</Term><Description><Para>2,2′,4,4′,5,5′-hexachlorobiphenyl</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>236-HCB</Term><Description><Para>2,2′,3,3′,6,6′-hexachlorobiphenyl</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>Mab</Term><Description><Para>monoclonal antibody</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Distribution and effects on cytochrome P450 system of two hexachlorobiphenyl isomers in the rat</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">M.</namePart><namePart type="family">Luotamo</namePart><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Elovaara</namePart><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Raunio</namePart><affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Pelkonen</namePart><affiliation>Department of Pharmacology, University of Oulu, Oulu, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Riihimäki</namePart><affiliation>Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Vainio</namePart><affiliation>International Agency for Research on Cancer, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">1991-10-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Tissue distribution and effects induced by 2,2′,4,4′,5,5′-hexachlorobiphenyl (245-HCB) on cytochrome P450 isozymes were compared with those of 2,2′,3,3′,6,6′-hexachlorobiphenyl (236-HCB). Male Wistar rats were given a single intragastric dose (23 mg/kg body wt) of either isomer, and killed after 72 h. At termination the tissue concentrations of 245-HCB were considerably higher than those of 236-HCB, suggesting a more effective metabolism of the latter. The binding affinity of 236-HCB to cytochrome P450 was higher and the magnitude of binding greater than of 245-HCB. 245-HCB-treatment elevated the hepatic concentration of cytochrome P450 and also the activities of 7-pentoxyresorufin O-depentylase (50-fold), aniline p-hydroxylase (2-fold) and 7-ethoxycoumarin O-deethylase (2-fold), a response typical of phenobarbital-type inducers. In the Western immunoblot of liver microsomes from 245-HCB treated rats, an increased amount of P450IIB1/2 was detected by a monoclonal antibody 2-66-3, which specifically detects phenobarbital inducible isoenzymes. The minimum molecular mass of the P450 isozyme induced was 52 kDa. After 236-HCB administration, a weak inducing effect was observed.</abstract><note>Original Investigations</note><subject><genre>Abbreviations</genre><topic>245-HCB : 2,2′,4,4′,5,5′-hexachlorobiphenyl</topic><topic>236-HCB : 2,2′,3,3′,6,6′-hexachlorobiphenyl</topic><topic>Mab : monoclonal antibody</topic></subject><relatedItem type="host"><titleInfo><title>Archives of Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>Arch Toxicol</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1991-10-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Cancer Research</topic><topic>Pharmacology/Toxicology</topic><topic>Allergology</topic></subject><identifier type="ISSN">0340-5761</identifier><identifier type="eISSN">1432-0738</identifier><identifier type="JournalID">204</identifier><identifier type="IssueArticleCount">16</identifier><identifier type="VolumeIssueCount">8</identifier><part><date>1991</date><detail type="volume"><number>65</number><caption>vol.</caption></detail><detail type="issue"><number>8</number><caption>no.</caption></detail><extent unit="pages"><start>661</start><end>665</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">CF078C5F237C9EA173C0CD44CB8A21B41B4BBF7D</identifier><identifier type="DOI">10.1007/BF02098033</identifier><identifier type="ArticleID">BF02098033</identifier><identifier type="ArticleID">Art9</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1991</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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