Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases
Identifieur interne : 000223 ( Main/Exploration ); précédent : 000222; suivant : 000224Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases
Auteurs : Mathieu Bourdenx [France] ; Jonathan Daniel [France] ; Emilie Genin [France] ; Federico N. Soria [France] ; Mireille Blanchard-Desce [France] ; Erwan Bezard [France] ; Benjamin Dehay [France]Source :
- Autophagy [ 1554-8627 ] ; 2016.
English descriptors
- KwdEn :
- 1-Methyl-4-phenylpyridinium, Acids (metabolism), Alkalies (chemistry), Animals, Cell Death, Dopaminergic Neurons (metabolism), Humans, Hydrogen-Ion Concentration, Injections, Intraventricular, Lactic Acid (chemistry), Lysosomal Storage Diseases (pathology), Lysosomes (metabolism), Lysosomes (ultrastructure), Mice, Models, Biological, Models, Genetic, Nanoparticles (chemistry), Nanoparticles (ultrastructure), Neostriatum (pathology), Nerve Degeneration (pathology), Parkinson Disease (pathology), Polyglycolic Acid (chemistry).
- MESH :
- chemical , chemistry : Alkalies, Lactic Acid, Polyglycolic Acid.
- chemical , metabolism : Acids.
- chemical : 1-Methyl-4-phenylpyridinium.
- chemistry : Nanoparticles.
- metabolism : Dopaminergic Neurons, Lysosomes.
- pathology : Lysosomal Storage Diseases, Neostriatum, Nerve Degeneration, Parkinson Disease.
- ultrastructure : Lysosomes, Nanoparticles.
- Animals, Cell Death, Humans, Hydrogen-Ion Concentration, Injections, Intraventricular, Mice, Models, Biological, Models, Genetic.
Abstract
Lysosomal impairment causes lysosomal storage disorders (LSD) and is involved in pathogenesis of neurodegenerative diseases, notably Parkinson disease (PD). Strategies enhancing or restoring lysosomal-mediated degradation thus appear as tantalizing disease-modifying therapeutics. Here we demonstrate that poly(DL-lactide-
Url:
DOI: 10.1080/15548627.2015.1136769
PubMed: 26761717
PubMed Central: 4835967
Affiliations:
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Le document en format XML
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type="wicri:Area/Main/Exploration">000223</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases</title><author><name sortKey="Bourdenx, Mathieu" sort="Bourdenx, Mathieu" uniqKey="Bourdenx M" first="Mathieu" last="Bourdenx">Mathieu Bourdenx</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Daniel, Jonathan" sort="Daniel, Jonathan" uniqKey="Daniel J" first="Jonathan" last="Daniel">Jonathan Daniel</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>University de Bordeaux, Institut des Sciences Moléculaires</institution>,<addr-line>UMR 5255</addr-line>, Talence,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Genin, Emilie" sort="Genin, Emilie" uniqKey="Genin E" first="Emilie" last="Genin">Emilie Genin</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>University de Bordeaux, Institut des Sciences Moléculaires</institution>,<addr-line>UMR 5255</addr-line>, Talence,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soria, Federico N" sort="Soria, Federico N" uniqKey="Soria F" first="Federico N." last="Soria">Federico N. Soria</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanchard Desce, Mireille" sort="Blanchard Desce, Mireille" uniqKey="Blanchard Desce M" first="Mireille" last="Blanchard-Desce">Mireille Blanchard-Desce</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>University de Bordeaux, Institut des Sciences Moléculaires</institution>,<addr-line>UMR 5255</addr-line>, Talence,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>University de Bordeaux, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>CNRS, Institut des Maladies Neurodégénératives</institution>,<addr-line>UMR 5293</addr-line>, Bordeaux,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="ISSN">1554-8627</idno><idno type="eISSN">1554-8635</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenylpyridinium</term><term>Acids (metabolism)</term><term>Alkalies (chemistry)</term><term>Animals</term><term>Cell Death</term><term>Dopaminergic Neurons (metabolism)</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Injections, Intraventricular</term><term>Lactic Acid (chemistry)</term><term>Lysosomal Storage Diseases (pathology)</term><term>Lysosomes (metabolism)</term><term>Lysosomes (ultrastructure)</term><term>Mice</term><term>Models, Biological</term><term>Models, Genetic</term><term>Nanoparticles (chemistry)</term><term>Nanoparticles (ultrastructure)</term><term>Neostriatum (pathology)</term><term>Nerve Degeneration (pathology)</term><term>Parkinson Disease (pathology)</term><term>Polyglycolic Acid (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Alkalies</term><term>Lactic Acid</term><term>Polyglycolic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acids</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenylpyridinium</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Lysosomes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lysosomal Storage Diseases</term><term>Neostriatum</term><term>Nerve Degeneration</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lysosomes</term><term>Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Injections, Intraventricular</term><term>Mice</term><term>Models, Biological</term><term>Models, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Lysosomal impairment causes lysosomal storage disorders (LSD) and is involved in pathogenesis of neurodegenerative diseases, notably Parkinson disease (PD). Strategies enhancing or restoring lysosomal-mediated degradation thus appear as tantalizing disease-modifying therapeutics. Here we demonstrate that poly(DL-lactide-<italic>co</italic>-glycolide) (PLGA) acidic nanoparticles (aNP) restore impaired lysosomal function in a series of toxin and genetic cellular models of PD, i.e. ATP13A2-mutant or depleted cells or glucocerebrosidase (GBA)-mutant cells, as well as in a genetic model of lysosomal-related myopathy. We show that PLGA-aNP are transported to the lysosome within 24 h, lower lysosomal pH and rescue chloroquine (CQ)-induced toxicity. Re-acidification of defective lysosomes following PLGA-aNP treatment restores lysosomal function in different pathological contexts. Finally, our results show that PLGA-aNP may be detected after intracerebral injection in neurons and attenuate PD-related neurodegeneration in vivo by mechanisms involving a rescue of compromised lysosomes.</p></div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Bourdenx, Mathieu" sort="Bourdenx, Mathieu" uniqKey="Bourdenx M" first="Mathieu" last="Bourdenx">Mathieu Bourdenx</name></noRegion><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><name sortKey="Blanchard Desce, Mireille" sort="Blanchard Desce, Mireille" uniqKey="Blanchard Desce M" first="Mireille" last="Blanchard-Desce">Mireille Blanchard-Desce</name><name sortKey="Bourdenx, Mathieu" sort="Bourdenx, Mathieu" uniqKey="Bourdenx M" first="Mathieu" last="Bourdenx">Mathieu Bourdenx</name><name sortKey="Daniel, Jonathan" sort="Daniel, Jonathan" uniqKey="Daniel J" first="Jonathan" last="Daniel">Jonathan Daniel</name><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name><name sortKey="Dehay, Benjamin" sort="Dehay, Benjamin" uniqKey="Dehay B" first="Benjamin" last="Dehay">Benjamin Dehay</name><name sortKey="Genin, Emilie" sort="Genin, Emilie" uniqKey="Genin E" first="Emilie" last="Genin">Emilie Genin</name><name sortKey="Soria, Federico N" sort="Soria, Federico N" uniqKey="Soria F" first="Federico N." last="Soria">Federico N. Soria</name><name sortKey="Soria, Federico N" sort="Soria, Federico N" uniqKey="Soria F" first="Federico N." last="Soria">Federico N. Soria</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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