Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers
Identifieur interne : 000274 ( Main/Exploration ); précédent : 000273; suivant : 000275Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers
Auteurs : Massiva Sayad [Algérie] ; Mohamed Zouambia [Algérie] ; Malika Chaouch [Algérie] ; Farida Ferrat [Algérie] ; Mustapha Nebbal [Algérie] ; Mohamed Bendini [Algérie] ; Suzanne Lesage [France] ; Alexis Brice [France] ; Mohamed Brahim Errahmani [Algérie] ; Boualem Asselah [Algérie]Source :
- BMC Neuroscience [ 1471-2202 ] ; 2016.
English descriptors
- KwdEn :
- Deep Brain Stimulation, Female, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Mutation, Parkinson Disease (genetics), Parkinson Disease (surgery), Parkinson Disease (therapy), Protein-Serine-Threonine Kinases (genetics), Subthalamic Nucleus (physiopathology), Treatment Outcome.
- MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical : Leucine-Rich Repeat Serine-Threonine Protein Kinase-2.
- genetics : Parkinson Disease.
- physiopathology : Subthalamic Nucleus.
- surgery : Parkinson Disease.
- therapy : Parkinson Disease.
- Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Mutation, Treatment Outcome.
- mix :
Abstract
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between the occurrence of dyskinesias and
We carried out a comparative statistical study for the clinical evaluation and neuropsychological assessment of 27 Algerian PD STN-DBS patients, both G2019S mutation carriers (MC) and non-carriers (NC). A multiple correspondence analysis (MCA) was then conducted to compare the results with those from groups of individuals with similar modalities.
The MCA revealed that MC and NC PD patients showed two different patterns of clinical evaluations. The group of idiopathic patients showed some differences compared to the clinical evaluations, depending on gender. No association was found between the G2019S mutation and the Mini Mental State Examination scores (MMSE), and MC patients appeared more susceptible to dyskinesia than NC patients. In NC patients, we found two cases with Parkin mutations who had a different “honeymoon” period and different initial symptoms. The results showed considerable improvement of motor unified parkinson’s disease rating scale III (UPDRS-III) in a situation of stimulation without medication in the MC patients with a percentage of improvement (51.1 %) over the required 30 % compared to the NC patients (25.5 %). The same result was observed for the Schwab and England’s activities of daily living scale (S and E scale), which thus demonstrated a greater effectiveness of DBS for MC patients than for NC patients. However, the Hoehn and Yahr scale (H and Y Scale) showed the same significance in a situation of stimulation for MC and NC patients. In this later group, the best scores of UPDRS-III were observed for patients with the Parkin mutation before they underwent surgery.
This study shows that surgical treatment probably has a more significant impact on
Url:
DOI: 10.1186/s12868-016-0240-4
PubMed: 26831335
PubMed Central: 4736184
Affiliations:
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Boumediene, El Alia, Bab Ezzouar, BP 32, 16111 Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of BPO, Faculty of SNV, Blida 1 University, BP 270, 09000 Blida, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of BPO, Faculty of SNV, Blida 1 University, BP 270, 09000 Blida</wicri:regionArea><wicri:noRegion>09000 Blida</wicri:noRegion></affiliation></author><author><name sortKey="Zouambia, Mohamed" sort="Zouambia, Mohamed" uniqKey="Zouambia M" first="Mohamed" last="Zouambia">Mohamed Zouambia</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111 Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111 Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Chaouch, Malika" sort="Chaouch, Malika" uniqKey="Chaouch M" first="Malika" last="Chaouch">Malika Chaouch</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neurology, CHU Ben Aknoun, 16000 Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of Neurology, CHU Ben Aknoun, 16000 Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Ferrat, Farida" sort="Ferrat, Farida" uniqKey="Ferrat F" first="Farida" last="Ferrat">Farida Ferrat</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neurology, CHU Ben Aknoun, 16000 Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of Neurology, CHU Ben Aknoun, 16000 Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Nebbal, Mustapha" sort="Nebbal, Mustapha" uniqKey="Nebbal M" first="Mustapha" last="Nebbal">Mustapha Nebbal</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of Neurosurgery, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Bendini, Mohamed" sort="Bendini, Mohamed" uniqKey="Bendini M" first="Mohamed" last="Bendini">Mohamed Bendini</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of Neurology, Mohamed-Seghir Nekkache Military Hospital, Djasr Kasentina, Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="3"><nlm:aff id="Aff6">UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff7">CNRS UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff8">The Brain and Spinal Cord Institute, 75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>The Brain and Spinal Cord Institute, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="Aff6">UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR S 1127 PaInserm U 1127, Sorbonne University, UPMC Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff7">CNRS UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff8">The Brain and Spinal Cord Institute, 75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>The Brain and Spinal Cord Institute, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brahim Errahmani, Mohamed" sort="Brahim Errahmani, Mohamed" uniqKey="Brahim Errahmani M" first="Mohamed" last="Brahim Errahmani">Mohamed Brahim Errahmani</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Department of Chemistry, Blida 1 University, BP 270, 09000 Blida, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Department of Chemistry, Blida 1 University, BP 270, 09000 Blida</wicri:regionArea><wicri:noRegion>09000 Blida</wicri:noRegion></affiliation></author><author><name sortKey="Asselah, Boualem" sort="Asselah, Boualem" uniqKey="Asselah B" first="Boualem" last="Asselah">Boualem Asselah</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111 Algiers, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Laboratory of Behavioral and Cognitive Neuroscience, FSB, University of Science and Technology Houari Boumediene, El Alia, Bab Ezzouar, BP 32, 16111 Algiers</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author></analytic><series><title level="j">BMC Neuroscience</title><idno type="eISSN">1471-2202</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (surgery)</term><term>Parkinson Disease (therapy)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Treatment Outcome</term></keywords><keywords scheme="mix" xml:lang="en"><term>LRRK2 (Leucine-rich repeat kinase 2) G2019S gene mutations</term><term>Mutation carrier (MC)</term><term>Non-carriers (NC)</term><term>Parkinson’s disease (PD)</term><term>Subthalamic Nucleus Deep Brain Stimulation (STN-DBS)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between the occurrence of dyskinesias and <italic>LRRK2</italic> (leucine-rich repeat kinase 2) G2019S gene mutations has recently been suggested. The aim of this study is to discover the impact of the G2019S mutation (with high incidence in the authors’ native Algeria) on the symptom response of PD in patients who underwent STN-DBS.</p></sec><sec><title>Methods</title><p>We carried out a comparative statistical study for the clinical evaluation and neuropsychological assessment of 27 Algerian PD STN-DBS patients, both G2019S mutation carriers (MC) and non-carriers (NC). A multiple correspondence analysis (MCA) was then conducted to compare the results with those from groups of individuals with similar modalities.</p></sec><sec><title>Results</title><p>The MCA revealed that MC and NC PD patients showed two different patterns of clinical evaluations. The group of idiopathic patients showed some differences compared to the clinical evaluations, depending on gender. No association was found between the G2019S mutation and the Mini Mental State Examination scores (MMSE), and MC patients appeared more susceptible to dyskinesia than NC patients. In NC patients, we found two cases with Parkin mutations who had a different “honeymoon” period and different initial symptoms. The results showed considerable improvement of motor unified parkinson’s disease rating scale III (UPDRS-III) in a situation of stimulation without medication in the MC patients with a percentage of improvement (51.1 %) over the required 30 % compared to the NC patients (25.5 %). The same result was observed for the Schwab and England’s activities of daily living scale (S and E scale), which thus demonstrated a greater effectiveness of DBS for MC patients than for NC patients. However, the Hoehn and Yahr scale (H and Y Scale) showed the same significance in a situation of stimulation for MC and NC patients. In this later group, the best scores of UPDRS-III were observed for patients with the Parkin mutation before they underwent surgery.</p></sec><sec><title>Conclusions</title><p>This study shows that surgical treatment probably has a more significant impact on <italic>LRRK2</italic> G2019S MC than on idiopathic patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Paisan Ruiz, C" uniqKey="Paisan Ruiz C">C Paisán-Ruíz</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Evans, Ew" uniqKey="Evans E">EW Evans</name></author><author><name sortKey="Gilks, Wp" uniqKey="Gilks W">WP Gilks</name></author><author><name sortKey="Sim N, J" uniqKey="Sim N J">J Simón</name></author><author><name sortKey="Van Der Brug, M" uniqKey="Van Der Brug M">M Van Der Brug</name></author><author><name sortKey="De Munain, Al" uniqKey="De Munain A">AL de Munain</name></author><author><name 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sortKey="Schnitzler, A" uniqKey="Schnitzler A">A Schnitzler</name></author><author><name sortKey="Lohmann, K" uniqKey="Lohmann K">K Lohmann</name></author><author><name sortKey="Pinsker, Mo" uniqKey="Pinsker M">MO Pinsker</name></author><author><name sortKey="Voges, J" uniqKey="Voges J">J Voges</name></author><author><name sortKey="Djarmatic, A" uniqKey="Djarmatic A">A Djarmatic</name></author><author><name sortKey="Seibler, P" uniqKey="Seibler P">P Seibler</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author><author><name sortKey="Rogaeva, E" uniqKey="Rogaeva E">E Rogaeva</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Klein, C" uniqKey="Klein C">C Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Yun, Jy" uniqKey="Yun J">JY Yun</name></author><author><name sortKey="Kim, Ye" uniqKey="Kim Y">YE Kim</name></author><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name></author><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Park, Ss" uniqKey="Park S">SS Park</name></author><author><name sortKey="Paek, Sh" uniqKey="Paek S">SH Paek</name></author><author><name sortKey="Jeon, Bs" uniqKey="Jeon B">BS Jeon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Algérie</li><li>France</li></country><region><li>Wilaya d'Alger</li><li>Île-de-France</li></region><settlement><li>Alger</li><li>Paris</li></settlement></list><tree><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Sayad, Massiva" sort="Sayad, Massiva" uniqKey="Sayad M" first="Massiva" last="Sayad">Massiva Sayad</name></region><name sortKey="Asselah, Boualem" sort="Asselah, Boualem" uniqKey="Asselah B" first="Boualem" last="Asselah">Boualem Asselah</name><name sortKey="Bendini, Mohamed" sort="Bendini, Mohamed" uniqKey="Bendini M" first="Mohamed" last="Bendini">Mohamed Bendini</name><name sortKey="Brahim Errahmani, Mohamed" sort="Brahim Errahmani, Mohamed" uniqKey="Brahim Errahmani M" first="Mohamed" last="Brahim Errahmani">Mohamed Brahim Errahmani</name><name sortKey="Chaouch, Malika" sort="Chaouch, Malika" uniqKey="Chaouch M" first="Malika" last="Chaouch">Malika Chaouch</name><name sortKey="Ferrat, Farida" sort="Ferrat, Farida" uniqKey="Ferrat F" first="Farida" last="Ferrat">Farida Ferrat</name><name sortKey="Nebbal, Mustapha" sort="Nebbal, Mustapha" uniqKey="Nebbal M" first="Mustapha" last="Nebbal">Mustapha Nebbal</name><name sortKey="Sayad, Massiva" sort="Sayad, Massiva" uniqKey="Sayad M" first="Massiva" last="Sayad">Massiva Sayad</name><name sortKey="Zouambia, Mohamed" sort="Zouambia, Mohamed" uniqKey="Zouambia M" first="Mohamed" last="Zouambia">Mohamed Zouambia</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name></region><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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