Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.
Identifieur interne : 000194 ( PubMed/Checkpoint ); précédent : 000193; suivant : 000195Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.
Auteurs : Lilian Calder N-Garcidue As [États-Unis] ; José Avila-Ramírez [Mexique] ; Ana Calder N-Garcidue As [Mexique] ; Tonatiuh González-Heredia [Mexique] ; Hilda Acu A-Ayala [Mexique] ; Chih-Kai Chao [États-Unis] ; Charles Thompson [États-Unis] ; Rubén Ruiz-Ramos [Mexique] ; Victor Cortés-González [Mexique] ; Luz Martínez-Martínez [Mexique] ; Mario Alberto García-Pérez [Mexique] ; Jacques Reis [France] ; Partha S. Mukherjee [États-Unis] ; Ricardo Torres-Jard N [Mexique] ; Ingolf Lachmann [Allemagne]Source :
- Journal of Alzheimer's disease : JAD [ 1875-8908 ] ; 2016.
Abstract
Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer's disease (AD) risk, while Mn toxicity induces parkinsonism. Mexico City Metropolitan Area (MCMA) children have pre- and postnatal sustained and high exposures to PM2.5, O3, polycyclic aromatic hydrocarbons, and metals. Young MCMA residents exhibit frontal tau hyperphosphorylation and amyloid-β (Aβ)1 - 42 diffuse plaques, and aggregated and hyperphosphorylated α-synuclein in olfactory nerves and key brainstem nuclei. We measured total prion protein (TPrP), total tau (T-tau), tau phosphorylated at threonine 181 (P-Tau), Aβ1-42, α-synuclein (t-α-syn and d-α-synuclein), BDNF, insulin, leptin, and/or inflammatory mediators, in 129 normal CSF samples from MCMA and clean air controls. Aβ1-42 and BDNF concentrations were significantly lower in MCMA children versus controls (p = 0.005 and 0.02, respectively). TPrP increased with cumulative PM2.5 up to 5 μg/m3 and then decreased, regardless of cumulative value or age (R2 = 0.56). TPrP strongly correlated with T-Tau and P-Tau, while d-α-synuclein showed a significant correlation with TNFα, IL10, and IL6 in MCMA children. Total synuclein showed an increment in childhood years related to cumulated PM2.5, followed by a decrease after age 12 years (R2 = 0.47), while d-α-synuclein exhibited a tendency to increase with cumulated PM2.5 (R2 = 0.30). CSF Aβ1-42, BDNF, α-synuclein, and TPrP changes are evolving in young MCMA urbanites historically showing underperformance in cognitive processes, odor identification deficits, downregulation of frontal cellular PrP, and neuropathological AD and PD hallmarks. Neuroprotection of young MCMA residents ought to be a public health priority.
DOI: 10.3233/JAD-160472
PubMed: 27567860
Affiliations:
- Allemagne, France, Mexique, États-Unis
- Alsace (région administrative), District de Leipzig, Grand Est, Idaho, Montana, Saxe (Land)
- Leipzig, Strasbourg
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:27567860Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.</title>
<author><name sortKey="Calder N Garcidue As, Lilian" sort="Calder N Garcidue As, Lilian" uniqKey="Calder N Garcidue As L" first="Lilian" last="Calder N-Garcidue As">Lilian Calder N-Garcidue As</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avila Ramirez, Jose" sort="Avila Ramirez, Jose" uniqKey="Avila Ramirez J" first="José" last="Avila-Ramírez">José Avila-Ramírez</name>
<affiliation wicri:level="1"><nlm:affiliation>Médica Sur, Mexico City, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Médica Sur, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calder N Garcidue As, Ana" sort="Calder N Garcidue As, Ana" uniqKey="Calder N Garcidue As A" first="Ana" last="Calder N-Garcidue As">Ana Calder N-Garcidue As</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Heredia, Tonatiuh" sort="Gonzalez Heredia, Tonatiuh" uniqKey="Gonzalez Heredia T" first="Tonatiuh" last="González-Heredia">Tonatiuh González-Heredia</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad del Valle de México, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad del Valle de México</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Acu A Ayala, Hilda" sort="Acu A Ayala, Hilda" uniqKey="Acu A Ayala H" first="Hilda" last="Acu A-Ayala">Hilda Acu A-Ayala</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad del Valle de México, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad del Valle de México</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chao, Chih Kai" sort="Chao, Chih Kai" uniqKey="Chao C" first="Chih-Kai" last="Chao">Chih-Kai Chao</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Charles" sort="Thompson, Charles" uniqKey="Thompson C" first="Charles" last="Thompson">Charles Thompson</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruiz Ramos, Ruben" sort="Ruiz Ramos, Ruben" uniqKey="Ruiz Ramos R" first="Rubén" last="Ruiz-Ramos">Rubén Ruiz-Ramos</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cortes Gonzalez, Victor" sort="Cortes Gonzalez, Victor" uniqKey="Cortes Gonzalez V" first="Victor" last="Cortés-González">Victor Cortés-González</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinez Martinez, Luz" sort="Martinez Martinez, Luz" uniqKey="Martinez Martinez L" first="Luz" last="Martínez-Martínez">Luz Martínez-Martínez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Perez, Mario Alberto" sort="Garcia Perez, Mario Alberto" uniqKey="Garcia Perez M" first="Mario Alberto" last="García-Pérez">Mario Alberto García-Pérez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Regional de Alta Especialidad, Ciudad Victoria, Tamaulipas, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital Regional de Alta Especialidad, Ciudad Victoria, Tamaulipas</wicri:regionArea>
<wicri:noRegion>Tamaulipas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reis, Jacques" sort="Reis, Jacques" uniqKey="Reis J" first="Jacques" last="Reis">Jacques Reis</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mukherjee, Partha S" sort="Mukherjee, Partha S" uniqKey="Mukherjee P" first="Partha S" last="Mukherjee">Partha S. Mukherjee</name>
<affiliation wicri:level="2"><nlm:affiliation>Mathematics Department, Boise State University, Boise, ID, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mathematics Department, Boise State University, Boise, ID</wicri:regionArea>
<placeName><region type="state">Idaho</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres Jard N, Ricardo" sort="Torres Jard N, Ricardo" uniqKey="Torres Jard N R" first="Ricardo" last="Torres-Jard N">Ricardo Torres-Jard N</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad Nacional Autónoma de México, Mexico City, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad Nacional Autónoma de México, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lachmann, Ingolf" sort="Lachmann, Ingolf" uniqKey="Lachmann I" first="Ingolf" last="Lachmann">Ingolf Lachmann</name>
<affiliation wicri:level="3"><nlm:affiliation>AJ Roboscreen GmbH, Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>AJ Roboscreen GmbH, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27567860</idno>
<idno type="pmid">27567860</idno>
<idno type="doi">10.3233/JAD-160472</idno>
<idno type="wicri:Area/PubMed/Corpus">000088</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000088</idno>
<idno type="wicri:Area/PubMed/Curation">000088</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000088</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000088</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000088</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.</title>
<author><name sortKey="Calder N Garcidue As, Lilian" sort="Calder N Garcidue As, Lilian" uniqKey="Calder N Garcidue As L" first="Lilian" last="Calder N-Garcidue As">Lilian Calder N-Garcidue As</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avila Ramirez, Jose" sort="Avila Ramirez, Jose" uniqKey="Avila Ramirez J" first="José" last="Avila-Ramírez">José Avila-Ramírez</name>
<affiliation wicri:level="1"><nlm:affiliation>Médica Sur, Mexico City, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Médica Sur, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calder N Garcidue As, Ana" sort="Calder N Garcidue As, Ana" uniqKey="Calder N Garcidue As A" first="Ana" last="Calder N-Garcidue As">Ana Calder N-Garcidue As</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Heredia, Tonatiuh" sort="Gonzalez Heredia, Tonatiuh" uniqKey="Gonzalez Heredia T" first="Tonatiuh" last="González-Heredia">Tonatiuh González-Heredia</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad del Valle de México, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad del Valle de México</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Acu A Ayala, Hilda" sort="Acu A Ayala, Hilda" uniqKey="Acu A Ayala H" first="Hilda" last="Acu A-Ayala">Hilda Acu A-Ayala</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad del Valle de México, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad del Valle de México</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chao, Chih Kai" sort="Chao, Chih Kai" uniqKey="Chao C" first="Chih-Kai" last="Chao">Chih-Kai Chao</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Charles" sort="Thompson, Charles" uniqKey="Thompson C" first="Charles" last="Thompson">Charles Thompson</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Montana, Missoula, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Montana, Missoula, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruiz Ramos, Ruben" sort="Ruiz Ramos, Ruben" uniqKey="Ruiz Ramos R" first="Rubén" last="Ruiz-Ramos">Rubén Ruiz-Ramos</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cortes Gonzalez, Victor" sort="Cortes Gonzalez, Victor" uniqKey="Cortes Gonzalez V" first="Victor" last="Cortés-González">Victor Cortés-González</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinez Martinez, Luz" sort="Martinez Martinez, Luz" uniqKey="Martinez Martinez L" first="Luz" last="Martínez-Martínez">Luz Martínez-Martínez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río</wicri:regionArea>
<wicri:noRegion>Boca del Río</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Perez, Mario Alberto" sort="Garcia Perez, Mario Alberto" uniqKey="Garcia Perez M" first="Mario Alberto" last="García-Pérez">Mario Alberto García-Pérez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Regional de Alta Especialidad, Ciudad Victoria, Tamaulipas, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Hospital Regional de Alta Especialidad, Ciudad Victoria, Tamaulipas</wicri:regionArea>
<wicri:noRegion>Tamaulipas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reis, Jacques" sort="Reis, Jacques" uniqKey="Reis J" first="Jacques" last="Reis">Jacques Reis</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mukherjee, Partha S" sort="Mukherjee, Partha S" uniqKey="Mukherjee P" first="Partha S" last="Mukherjee">Partha S. Mukherjee</name>
<affiliation wicri:level="2"><nlm:affiliation>Mathematics Department, Boise State University, Boise, ID, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mathematics Department, Boise State University, Boise, ID</wicri:regionArea>
<placeName><region type="state">Idaho</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres Jard N, Ricardo" sort="Torres Jard N, Ricardo" uniqKey="Torres Jard N R" first="Ricardo" last="Torres-Jard N">Ricardo Torres-Jard N</name>
<affiliation wicri:level="1"><nlm:affiliation>Universidad Nacional Autónoma de México, Mexico City, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Universidad Nacional Autónoma de México, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lachmann, Ingolf" sort="Lachmann, Ingolf" uniqKey="Lachmann I" first="Ingolf" last="Lachmann">Ingolf Lachmann</name>
<affiliation wicri:level="3"><nlm:affiliation>AJ Roboscreen GmbH, Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>AJ Roboscreen GmbH, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Alzheimer's disease : JAD</title>
<idno type="eISSN">1875-8908</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer's disease (AD) risk, while Mn toxicity induces parkinsonism. Mexico City Metropolitan Area (MCMA) children have pre- and postnatal sustained and high exposures to PM2.5, O3, polycyclic aromatic hydrocarbons, and metals. Young MCMA residents exhibit frontal tau hyperphosphorylation and amyloid-β (Aβ)1 - 42 diffuse plaques, and aggregated and hyperphosphorylated α-synuclein in olfactory nerves and key brainstem nuclei. We measured total prion protein (TPrP), total tau (T-tau), tau phosphorylated at threonine 181 (P-Tau), Aβ1-42, α-synuclein (t-α-syn and d-α-synuclein), BDNF, insulin, leptin, and/or inflammatory mediators, in 129 normal CSF samples from MCMA and clean air controls. Aβ1-42 and BDNF concentrations were significantly lower in MCMA children versus controls (p = 0.005 and 0.02, respectively). TPrP increased with cumulative PM2.5 up to 5 μg/m3 and then decreased, regardless of cumulative value or age (R2 = 0.56). TPrP strongly correlated with T-Tau and P-Tau, while d-α-synuclein showed a significant correlation with TNFα, IL10, and IL6 in MCMA children. Total synuclein showed an increment in childhood years related to cumulated PM2.5, followed by a decrease after age 12 years (R2 = 0.47), while d-α-synuclein exhibited a tendency to increase with cumulated PM2.5 (R2 = 0.30). CSF Aβ1-42, BDNF, α-synuclein, and TPrP changes are evolving in young MCMA urbanites historically showing underperformance in cognitive processes, odor identification deficits, downregulation of frontal cellular PrP, and neuropathological AD and PD hallmarks. Neuroprotection of young MCMA residents ought to be a public health priority.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27567860</PMID>
<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>10</Day>
</DateCreated>
<DateRevised><Year>2016</Year>
<Month>09</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-8908</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>54</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
<Month>Sep</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Journal of Alzheimer's disease : JAD</Title>
<ISOAbbreviation>J. Alzheimers Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.</ArticleTitle>
<Pagination><MedlinePgn>597-613</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3233/JAD-160472</ELocationID>
<Abstract><AbstractText>Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer's disease (AD) risk, while Mn toxicity induces parkinsonism. Mexico City Metropolitan Area (MCMA) children have pre- and postnatal sustained and high exposures to PM2.5, O3, polycyclic aromatic hydrocarbons, and metals. Young MCMA residents exhibit frontal tau hyperphosphorylation and amyloid-β (Aβ)1 - 42 diffuse plaques, and aggregated and hyperphosphorylated α-synuclein in olfactory nerves and key brainstem nuclei. We measured total prion protein (TPrP), total tau (T-tau), tau phosphorylated at threonine 181 (P-Tau), Aβ1-42, α-synuclein (t-α-syn and d-α-synuclein), BDNF, insulin, leptin, and/or inflammatory mediators, in 129 normal CSF samples from MCMA and clean air controls. Aβ1-42 and BDNF concentrations were significantly lower in MCMA children versus controls (p = 0.005 and 0.02, respectively). TPrP increased with cumulative PM2.5 up to 5 μg/m3 and then decreased, regardless of cumulative value or age (R2 = 0.56). TPrP strongly correlated with T-Tau and P-Tau, while d-α-synuclein showed a significant correlation with TNFα, IL10, and IL6 in MCMA children. Total synuclein showed an increment in childhood years related to cumulated PM2.5, followed by a decrease after age 12 years (R2 = 0.47), while d-α-synuclein exhibited a tendency to increase with cumulated PM2.5 (R2 = 0.30). CSF Aβ1-42, BDNF, α-synuclein, and TPrP changes are evolving in young MCMA urbanites historically showing underperformance in cognitive processes, odor identification deficits, downregulation of frontal cellular PrP, and neuropathological AD and PD hallmarks. Neuroprotection of young MCMA residents ought to be a public health priority.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calderón-Garcidueñas</LastName>
<ForeName>Lilian</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>The University of Montana, Missoula, MT, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Universidad del Valle de México, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Avila-Ramírez</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Médica Sur, Mexico City, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calderón-Garcidueñas</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>González-Heredia</LastName>
<ForeName>Tonatiuh</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Universidad del Valle de México, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Acuña-Ayala</LastName>
<ForeName>Hilda</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Universidad del Valle de México, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chao</LastName>
<ForeName>Chih-Kai</ForeName>
<Initials>CK</Initials>
<AffiliationInfo><Affiliation>The University of Montana, Missoula, MT, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Charles</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>The University of Montana, Missoula, MT, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ruiz-Ramos</LastName>
<ForeName>Rubén</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Instituto de Medicina Forense, Universidad Veracruzana, Boca del Río, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cortés-González</LastName>
<ForeName>Victor</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martínez-Martínez</LastName>
<ForeName>Luz</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Hospital de Especialidades No. 14, I.M.S.S, Boca del Río, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-Pérez</LastName>
<ForeName>Mario Alberto</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Hospital Regional de Alta Especialidad, Ciudad Victoria, Tamaulipas, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reis</LastName>
<ForeName>Jacques</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Service de Neurologie, Centre Hospitalier Universitaire, Hôpital de Hautepierre, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mukherjee</LastName>
<ForeName>Partha S</ForeName>
<Initials>PS</Initials>
<AffiliationInfo><Affiliation>Mathematics Department, Boise State University, Boise, ID, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Torres-Jardón</LastName>
<ForeName>Ricardo</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Universidad Nacional Autónoma de México, Mexico City, México.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lachmann</LastName>
<ForeName>Ingolf</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>AJ Roboscreen GmbH, Leipzig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Alzheimers Dis</MedlineTA>
<NlmUniqueID>9814863</NlmUniqueID>
<ISSNLinking>1387-2877</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Air pollution</Keyword>
<Keyword MajorTopicYN="N">Alzheimer’s disease</Keyword>
<Keyword MajorTopicYN="N">BDNF</Keyword>
<Keyword MajorTopicYN="N">Mexico City</Keyword>
<Keyword MajorTopicYN="N">PM2.5</Keyword>
<Keyword MajorTopicYN="N">Parkinson</Keyword>
<Keyword MajorTopicYN="N">amyloid-β1–42</Keyword>
<Keyword MajorTopicYN="N">cerebrospinal fluid</Keyword>
<Keyword MajorTopicYN="N">children</Keyword>
<Keyword MajorTopicYN="N">insulin</Keyword>
<Keyword MajorTopicYN="N">leptin</Keyword>
<Keyword MajorTopicYN="N">prion cellular protein</Keyword>
<Keyword MajorTopicYN="N">α-synuclein</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>8</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>8</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>8</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27567860</ArticleId>
<ArticleId IdType="pii">JAD160472</ArticleId>
<ArticleId IdType="doi">10.3233/JAD-160472</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Mexique</li>
<li>États-Unis</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>District de Leipzig</li>
<li>Grand Est</li>
<li>Idaho</li>
<li>Montana</li>
<li>Saxe (Land)</li>
</region>
<settlement><li>Leipzig</li>
<li>Strasbourg</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Montana"><name sortKey="Calder N Garcidue As, Lilian" sort="Calder N Garcidue As, Lilian" uniqKey="Calder N Garcidue As L" first="Lilian" last="Calder N-Garcidue As">Lilian Calder N-Garcidue As</name>
</region>
<name sortKey="Chao, Chih Kai" sort="Chao, Chih Kai" uniqKey="Chao C" first="Chih-Kai" last="Chao">Chih-Kai Chao</name>
<name sortKey="Mukherjee, Partha S" sort="Mukherjee, Partha S" uniqKey="Mukherjee P" first="Partha S" last="Mukherjee">Partha S. Mukherjee</name>
<name sortKey="Thompson, Charles" sort="Thompson, Charles" uniqKey="Thompson C" first="Charles" last="Thompson">Charles Thompson</name>
</country>
<country name="Mexique"><noRegion><name sortKey="Avila Ramirez, Jose" sort="Avila Ramirez, Jose" uniqKey="Avila Ramirez J" first="José" last="Avila-Ramírez">José Avila-Ramírez</name>
</noRegion>
<name sortKey="Acu A Ayala, Hilda" sort="Acu A Ayala, Hilda" uniqKey="Acu A Ayala H" first="Hilda" last="Acu A-Ayala">Hilda Acu A-Ayala</name>
<name sortKey="Calder N Garcidue As, Ana" sort="Calder N Garcidue As, Ana" uniqKey="Calder N Garcidue As A" first="Ana" last="Calder N-Garcidue As">Ana Calder N-Garcidue As</name>
<name sortKey="Cortes Gonzalez, Victor" sort="Cortes Gonzalez, Victor" uniqKey="Cortes Gonzalez V" first="Victor" last="Cortés-González">Victor Cortés-González</name>
<name sortKey="Garcia Perez, Mario Alberto" sort="Garcia Perez, Mario Alberto" uniqKey="Garcia Perez M" first="Mario Alberto" last="García-Pérez">Mario Alberto García-Pérez</name>
<name sortKey="Gonzalez Heredia, Tonatiuh" sort="Gonzalez Heredia, Tonatiuh" uniqKey="Gonzalez Heredia T" first="Tonatiuh" last="González-Heredia">Tonatiuh González-Heredia</name>
<name sortKey="Martinez Martinez, Luz" sort="Martinez Martinez, Luz" uniqKey="Martinez Martinez L" first="Luz" last="Martínez-Martínez">Luz Martínez-Martínez</name>
<name sortKey="Ruiz Ramos, Ruben" sort="Ruiz Ramos, Ruben" uniqKey="Ruiz Ramos R" first="Rubén" last="Ruiz-Ramos">Rubén Ruiz-Ramos</name>
<name sortKey="Torres Jard N, Ricardo" sort="Torres Jard N, Ricardo" uniqKey="Torres Jard N R" first="Ricardo" last="Torres-Jard N">Ricardo Torres-Jard N</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Reis, Jacques" sort="Reis, Jacques" uniqKey="Reis J" first="Jacques" last="Reis">Jacques Reis</name>
</region>
</country>
<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Lachmann, Ingolf" sort="Lachmann, Ingolf" uniqKey="Lachmann I" first="Ingolf" last="Lachmann">Ingolf Lachmann</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000194 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000194 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:27567860 |texte= Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:27567860" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |