Presynaptic dopaminergic function in the striatum of schizophrenic patients
Identifieur interne : 004300 ( Main/Exploration ); précédent : 004299; suivant : 004301Presynaptic dopaminergic function in the striatum of schizophrenic patients
Auteurs : Marie-Hélène Dao-Castellana [France] ; Marie-Laure Paillère-Martinot [France] ; Philippe Hantraye [France] ; Dominique Attar-Lévy [France] ; Philippe Rémy [France] ; Christian Crouzel [France] ; Eric Artiges [France] ; André Féline [France] ; André Syrota [France] ; Jean-Luc Martinot [France]Source :
- Schizophrenia Research [ 0920-9964 ] ; 1997.
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Abstract
Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.
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DOI: 10.1016/S0920-9964(96)00102-8
Affiliations:
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Chenevier, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Schizophrenia Research</title><title level="j" type="abbrev">SCHRES</title><idno type="ISSN">0920-9964</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="174">174</biblScope></imprint><idno type="ISSN">0920-9964</idno></series><idno type="istex">28121A469906EDF10A6C0E7957A0D44EE9D577C3</idno><idno type="DOI">10.1016/S0920-9964(96)00102-8</idno><idno type="PII">S0920-9964(96)00102-8</idno><idno type="ArticleID">96001028</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0920-9964</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F-DOPA</term><term>Dopamine</term><term>PET</term><term>Schizophrenia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Orsay</li><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Dao Castellana, Marie Helene" sort="Dao Castellana, Marie Helene" uniqKey="Dao Castellana M" first="Marie-Hélène" last="Dao-Castellana">Marie-Hélène Dao-Castellana</name></noRegion><name sortKey="Artiges, Eric" sort="Artiges, Eric" uniqKey="Artiges E" first="Eric" last="Artiges">Eric Artiges</name><name sortKey="Attar Levy, Dominique" sort="Attar Levy, Dominique" uniqKey="Attar Levy D" first="Dominique" last="Attar-Lévy">Dominique Attar-Lévy</name><name sortKey="Crouzel, Christian" sort="Crouzel, Christian" uniqKey="Crouzel C" first="Christian" last="Crouzel">Christian Crouzel</name><name sortKey="Dao Castellana, Marie Helene" sort="Dao Castellana, Marie Helene" uniqKey="Dao Castellana M" first="Marie-Hélène" last="Dao-Castellana">Marie-Hélène Dao-Castellana</name><name sortKey="Feline, Andre" sort="Feline, Andre" uniqKey="Feline A" first="André" last="Féline">André Féline</name><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name><name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name><name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name><name sortKey="Paillere Martinot, Marie Laure" sort="Paillere Martinot, Marie Laure" uniqKey="Paillere Martinot M" first="Marie-Laure" last="Paillère-Martinot">Marie-Laure Paillère-Martinot</name><name sortKey="Paillere Martinot, Marie Laure" sort="Paillere Martinot, Marie Laure" uniqKey="Paillere Martinot M" first="Marie-Laure" last="Paillère-Martinot">Marie-Laure Paillère-Martinot</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Rémy">Philippe Rémy</name><name sortKey="Syrota, Andre" sort="Syrota, Andre" uniqKey="Syrota A" first="André" last="Syrota">André Syrota</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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